The FATZO mouse, a next generation model of type 2 diabetes, develops NAFLD and NASH when fed a Western diet supplemented with fructose

Autor: Gao Sun, Charles V. Jackson, Karen Zimmerman, Li-Kun Zhang, Courtney M. Finnearty, George E. Sandusky, Guodong Zhang, Richard G. Peterson, Yi-Xin (Jim) Wang

Publikováno v: BMC Gastroenterology, Vol 19, Iss 1, Pp 1-11 (2019)

Abstract Background Metabolic disorders such as insulin resistance, obesity, and hyperglycemia are prominent risk factors for the development of non-alcoholic fatty liver disease (NAFLD)/steatohepatitis (NASH). Dietary rodent models employ high fat,

Externí odkaz: https://doaj.org/article/94d47ec6dd364d2985b6a79a72c89c6a

Inhibition of soluble epoxide hydrolase attenuates endothelial dysfunction in animal models of diabetes, obesity and hypertension

Autor: Yi-Xin Jim Wang, Richard D. Gless, D. Euan MacIntyre, Gabor Rubanyi, Le-Ning Zhang, Sampath-Kumar Anandan, Heather K. Webb, Dawn Chen, Jon Vincelette

Publikováno v: European Journal of Pharmacology. 654:68-74

Endothelial dysfunction is a hallmark of, and plays a pivotal role in the pathogenesis of cardiometabolic diseases, including type II diabetes, obesity, and hypertension. It has been well established that epoxyeicosatrienoic acids (EETs) act as an en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d29c5146e5ae75db5f7f7933f53e62
https://doi.org/10.1016/j.ejphar.2010.12.016

Soluble Epoxide Hydrolase in Atherosclerosis

Autor: Bruce D. Hammock, Yi Xin Jim Wang, Le Ning Zhang, Arzu Ulu

Publikováno v: Current Atherosclerosis Reports
Wang, Yi-Xin Jim; Ulu, Arzu; Zhang, Le-Ning; & Hammock, Bruce. (2010). Soluble Epoxide Hydrolase in Atherosclerosis. Current Atherosclerosis Reports, 12(3), pp 174-183. doi: 10.1007/s11883-010-0108-5. Retrieved from: http://www.escholarship.org/uc/item/64g1c51d

Like many eicosanoids, epoxyeicosatrienoic acids (EETs) have multiple biological functions, including reduction of blood pressure, inflammation, and atherosclerosis in multiple species. Hydration of EETs by the soluble epoxide hydrolase (sEH) is the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::175794c4e2aefb36be36b52a09cdc168
https://doi.org/10.1007/s11883-010-0108-5

Angiotensin II induces histomorphologic features of unstable plaque in a murine model of accelerated atherosclerosis

Autor: Dennis W Wilson, Miriam Schroeder, Yi-Xin Jim Wang, David F. Choy, Ronald Vergona, Valdeci da Cunha, Baby Martin-McNulty, Jon Vincelette, Mithra Mahmoudi, Mark E. Sullivan, Meredith Halks-Miller, We-Wei Li

Publikováno v: Journal of Vascular Surgery. 44:364-371

BackgroundWe explored the role of angiotensin II in determining the histomorphometric features of plaque stability in apolipoprotein E–deficient mice submitted to ligation of the carotid artery.MethodsSix-month-old apolipoprotein E–deficient mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adef4a7efc67f3bd1aca63695d55d82e
https://doi.org/10.1016/j.jvs.2006.04.033

Inhibition of soluble epoxide hydrolase attenuated atherosclerosis, abdominal aortic aneurysm formation, and dyslipidemia

Autor: Upasana Mehra, Le-Ning Zhang, Jon Vincelette, Yi-Xin Jim Wang, Ying Cheng, Dawn Chen, Sampath-Kumar Anandan, Richard D. Gless, Heather K. Webb

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology. 29(9)

Objective— Epoxyeicosatrienoic acids (EETs) have been shown to have antiinflammatory effects and therefore may play a role in preventing vascular inflammatory and atherosclerotic diseases. Soluble epoxide hydrolase (s-EH) converts EETs into less bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1fb266639545c44aabb4aa2ba676c0
https://pubmed.ncbi.nlm.nih.gov/19667112