Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Yi-Tao Yu"'
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1284 (2024)
Nonsense mutations are genetic mutations that create premature termination codons (PTCs), leading to truncated, defective proteins in diseases such as cystic fibrosis, neurofibromatosis type 1, Dravet syndrome, Hurler syndrome, Beta thalassemia, inhe
Externí odkaz:
https://doaj.org/article/dc0abfb2ff974808ba7bc0f4948b6dde
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The current COVID-19 pandemic is a massive source of global disruption, having led so far to two hundred and fifty million COVID-19 cases and almost five million deaths worldwide. It was recognized in the beginning that only an effective vaccine coul
Externí odkaz:
https://doaj.org/article/fb6a4596b2f94b4cbe9d7cc377d7a8b6
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Small nuclear RNAs (snRNAs) are critical components of the spliceosome that catalyze the splicing of pre-mRNA. snRNAs are each complexed with many proteins to form RNA-protein complexes, termed as small nuclear ribonucleoproteins (snRNPs), in the cel
Externí odkaz:
https://doaj.org/article/33c123b984a742129674da2e749645dd
Publikováno v:
Biology Open, Vol 6, Iss 9, Pp 1342-1354 (2017)
Many ribonucleoproteins (RNPs), which are comprised of noncoding RNA and associated proteins, are involved in essential cellular processes such as translation and pre-mRNA splicing. One class of RNP is the small Cajal body-specific RNP (scaRNP), whic
Externí odkaz:
https://doaj.org/article/42b851a613c3450d98e3c4b07a3c6f17
Publikováno v:
Biomedicines, Vol 9, Iss 5, p 550 (2021)
Therapeutic oligonucleotides interact with a target RNA via Watson-Crick complementarity, affecting RNA-processing reactions such as mRNA degradation, pre-mRNA splicing, or mRNA translation. Since they were proposed decades ago, several have been app
Externí odkaz:
https://doaj.org/article/572256d2474b42de9af59d6f117e7179
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 12, p 4394 (2020)
Nonsense mutations often result from single nucleotide substitutions that change a sense codon (coding for an amino acid) to a nonsense or premature termination codon (PTC) within the coding region of a gene. The impact of nonsense mutations is two-f
Externí odkaz:
https://doaj.org/article/399148fb0a5a40f59dc7f75b85360b7c
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 6 (2018)
Pseudouridine is the most abundant internal RNA modification in stable noncoding RNAs (ncRNAs). It can be catalyzed by both RNA-dependent and RNA-independent mechanisms. Pseudouridylation impacts both the biochemical and biophysical properties of RNA
Externí odkaz:
https://doaj.org/article/ec9bb0126c9647eeb5280c90597df755
Publikováno v:
Genes, Vol 8, Iss 11, p 295 (2017)
5-fluorouracil (5-FU) is a chemotherapeutic agent that has been extensively studied since its initial development in the 1950s. It has been suggested that the mechanism of action of 5-FU involves both DNA- and RNA-directed processes, but this has rem
Externí odkaz:
https://doaj.org/article/f73b6c518a6245dca579bab90f05e706
Publikováno v:
Biochemical Journal; Jan2024, Vol. 481 Issue 1, p1-16, 16p
Publikováno v:
Methods in Molecular Biology ISBN: 9781071631904
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fab01df71dd328c19eb2f69566be3242
https://doi.org/10.1007/978-1-0716-3191-1_14
https://doi.org/10.1007/978-1-0716-3191-1_14