Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Yi-Shuian Huang"'
Autor:
Wen-Hsin Lu, Tzu-Tung Chang, Yao-Ming Chang, Yi-Hsiang Liu, Chia-Hsuan Lin, Ching-Shu Suen, Ming-Jing Hwang, Yi-Shuian Huang
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-19 (2024)
Abstract Background Local translation at synapses is important for rapidly remodeling the synaptic proteome to sustain long-term plasticity and memory. While the regulatory mechanisms underlying memory-associated local translation have been widely el
Externí odkaz:
https://doaj.org/article/53cb4e1769224b58ad936a39d7a2da74
Publikováno v:
eLife, Vol 13 (2024)
Experimental detection of residues critical for protein–protein interactions (PPI) is a time-consuming, costly, and labor-intensive process. Hence, high-throughput PPI-hot spot prediction methods have been developed, but they have been validated us
Externí odkaz:
https://doaj.org/article/02fbed149f19420a840b80310265b0b7
Publikováno v:
Molecular Metabolism, Vol 89, Iss , Pp 102034- (2024)
Objective: Brown adipose tissue (BAT) plays an important role in mammalian thermogenesis through the expression of uncoupling protein 1 (UCP1). Our previous study identified cytoplasmic polyadenylation element binding protein 2 (CPEB2) as a key regul
Externí odkaz:
https://doaj.org/article/962f591a3e5544abaae4ba165ea9d6ce
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Long-term maintenance of synaptic connections is important for brain function, which depends on varying proteostatic regulations to govern the functional integrity of neuronal proteomes. Proteostasis supports an interconnection of pathways that regul
Externí odkaz:
https://doaj.org/article/9fd7dc2603e843b2948bd50ae3b5bd93
Publikováno v:
Journal of Biomedical Science, Vol 27, Iss 1, Pp 1-17 (2020)
Abstract Background Alveologenesis is the final stage of lung development to form air-exchanging units between alveoli and blood vessels. Genetic susceptibility or hyperoxic stress to perturb this complicated process can cause abnormal enlargement of
Externí odkaz:
https://doaj.org/article/1142990fc9a4469089c79f015c25558e
Publikováno v:
Frontiers in Pediatrics, Vol 8 (2021)
Brown adipose tissue (BAT) is a thermogenic organ owing to its unique expression of uncoupling protein 1 (UCP1), which is a proton channel in the inner mitochondrial membrane used to dissipate the proton gradient and uncouple the electron transport c
Externí odkaz:
https://doaj.org/article/87e57f5d33994936a114cacfcbf1f637
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108269- (2020)
Summary: Eukaryotic mRNAs are 5′ end capped with a 7-methylguanosine, which is important for processing and translation of mRNAs. Cap methyltransferase 1 (CMTR1) catalyzes 2′-O-ribose methylation of the first transcribed nucleotide (N1 2′-O-Me)
Externí odkaz:
https://doaj.org/article/62072538263a4dac914fb3917585f521
Publikováno v:
Cell Reports, Vol 21, Iss 7, Pp 1783-1794 (2017)
Summary: Activity-dependent synthesis of plasticity-related proteins is necessary to sustain long-lasting synaptic modifications and consolidate memory. We investigated the role of the translational regulator cytoplasmic polyadenylation element bindi
Externí odkaz:
https://doaj.org/article/8a96a82d603c4abbb1a737baf673b3d4
Publikováno v:
Cell Reports, Vol 21, Iss 8, Pp 2264-2276 (2017)
Mammalian olfactory bulbs (OBs) require continuous replenishment of interneurons (mainly granule cells [GCs]) to support local circuits throughout life. Two spatiotemporally distinct waves of postnatal neurogenesis contribute to expanding and maintai
Externí odkaz:
https://doaj.org/article/ae05738886c249a897e804972fdc79a7
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 13 (2019)
The rodent olfactory bulb (OB) contains two distinct populations of postnatally born interneurons, mainly granule cells (GCs), to support local circuits throughout life. During the early postnatal period (i.e., 2 weeks after birth), GCs are mostly pr
Externí odkaz:
https://doaj.org/article/0bf8dc9a26094fa292f3a5b2bda87bca