Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Yi-Shuai Zhang"'
Autor:
De-Jian Liu, Xiu-Qin Zhong, Yan-Xia Ru, Shi-Long Zhao, Cui-Cui Liu, Yi-Bo Tang, Xuan Wu, Yi-Shuai Zhang, Hui-Hui Zhang, Jia-Yue She, Mu-Yang Wan, Yao-Wang Li, He-Ping Zheng, Lei Deng
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
Influenza virus infection poses a continual menace to public health. Here, we developed soluble trimeric HA ectodomain vaccines by establishing interprotomer disulfide bonds in the stem region, which effectively preserve the native antigenicity of st
Externí odkaz:
https://doaj.org/article/fa863d518642489190818558b0e7feed
Autor:
Chen Yan, Chongyang Zhang, Jing Wang, Xiaochun Long, Yu-Jun Cai, Amy Mohan, Yi-shuai Zhang, Danfei Lou, Jian Xiong, Hangchuan Shi, Hongmei Zhao
Publikováno v:
Proc Natl Acad Sci U S A
Abdominal aortic aneurysm (AAA) is characterized by aorta dilation due to wall degeneration, which mostly occurs in elderly males. Vascular aging is implicated in degenerative vascular pathologies, including AAA. Cyclic nucleotide phosphodiesterases,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b34864f4ef9ef1b33c579e80e508fd5
https://doi.org/10.1073/pnas.2107898118
https://doi.org/10.1073/pnas.2107898118
Publikováno v:
European journal of pharmacology. 900
Rationale Higenamine (HG), is one of the main active components in many widely used Chinese herbs, and a common ingredient of health products in Europe and North America. Several groups, including our own, have previously shown the beneficial effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::973ed74b21b0fc435b42a5db5d2c12f8
https://pubmed.ncbi.nlm.nih.gov/33766620
https://pubmed.ncbi.nlm.nih.gov/33766620
Autor:
Deanne Mickelsen, Si Chen, Yi-shuai Zhang, Eric M. Small, Chen Yan, Peng Yao, Jiangbin Wu, Janet K. Lighthouse
Publikováno v:
Circulation
Background: Heart failure is a leading cause of death worldwide. Cyclic nucleotide phosphodiesterases (PDEs), through degradation of cyclic nucleotides, play critical roles in cardiovascular biology and disease. Our preliminary screening studies have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f65a2d3c30b337a229e387014a90653
https://europepmc.org/articles/PMC7147986/
https://europepmc.org/articles/PMC7147986/
Autor:
Xiu-Ju Luo, Nian-Sheng Li, Bin Liu, Xiao-Jie Zhang, Li-Jing Tang, Shi-Jing Wang, Hua Tu, Yi-Shuai Zhang, Jun Peng
Publikováno v:
European Journal of Pharmacology. 822:1-12
Fasudil is a potent Rho-kinase (ROCK) inhibitor and can relax smooth muscle or cardiac muscle contraction through decreasing the phosphorylation level of myosin regulatory light chain (p-MLC20 or p-MLC2v), while p-MLC2v can function as a transcriptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c14cab017d5d84f4a5f3065fdb8309c
https://doi.org/10.1016/j.ejphar.2018.01.007
https://doi.org/10.1016/j.ejphar.2018.01.007
Publikováno v:
European Journal of Pharmacology. 819:30-34
Vinpocetine, a derivative of the alkaloid vincamine, has been clinically used in many countries for treatment of cerebrovascular disorders such as stroke and dementia for more than 30 years. Currently, vinpocetine is also available in the market as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f46b52facf2f56bccb3a3b40ccd3b5e
https://doi.org/10.1016/j.ejphar.2017.11.041
https://doi.org/10.1016/j.ejphar.2017.11.041
Publikováno v:
Circulation. 138(18)
Background: cAMP plays a critical role in regulating cardiomyocyte survival. Various cAMP signaling pathways behave distinctly or in opposition. We have previously reported that activation of cAMP hydrolysis by cyclic nucleotide phosphodiesterase 1C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6743ff3cf306fd3be2922a28bcdca9
https://pubmed.ncbi.nlm.nih.gov/30372138
https://pubmed.ncbi.nlm.nih.gov/30372138
Autor:
Xiu-Ju Luo, Qi Lin Ma, Qingjie Li, Yi Shuai Zhang, Nian Sheng Li, Yuan-Jian Li, Bin Liu, Jun Lin Jiang, Jie Jie Zhang, Jun Peng
Publikováno v:
Free Radical Biology and Medicine. 83:115-128
Nuclear myosin regulates gene transcription and this novel function might be modulated through phosphorylation of the myosin regulatory light chain (p-MLC20). Nonmuscle MLC20 (nmMLC20) is also present in the nuclei of cardiomyocytes and a potential n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d111fce1280e321bfc120151c91997
https://doi.org/10.1016/j.freeradbiomed.2015.02.013
https://doi.org/10.1016/j.freeradbiomed.2015.02.013
Autor:
Ting-Ting Li1,2 (AUTHOR), Yi-Shuai Zhang1 (AUTHOR), Lan He1 (AUTHOR), Bin Liu1 (AUTHOR), Rui-Zheng Shi3 (AUTHOR), Guo-Gang Zhang3 (AUTHOR), Jun Peng1 (AUTHOR) Junpeng@csu.edu.cn
Publikováno v:
Canadian Journal of Physiology & Pharmacology. Jul2012, Vol. 90 Issue 7, p851-862. 12p. 4 Color Photographs, 2 Charts, 2 Graphs.
Autor:
Chen Yan, Deanne Mickelsen, Masayoshi Oikawa, Clint L. Miller, Eric M. Small, Walter E. Knight, Christine S. Moravec, Yi-shuai Zhang, Si Chen, Mei-ping Wu, Yu-Jun Cai, Jun Ichi Abe, Qian Zhou
Cyclic nucleotide phosphodiesterase 1C (PDE1C) represents a major phosphodiesterase activity in human myocardium, but its function in the heart remains unknown. Using genetic and pharmacological approaches, we studied the expression, regulation, func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461eff15376648afeff0af49f39ef62b
https://europepmc.org/articles/PMC5111646/
https://europepmc.org/articles/PMC5111646/