Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Yi-Ling Du"'
Publikováno v:
Synthetic and Systems Biotechnology, Vol 9, Iss 4, Pp 766-774 (2024)
The anti-Clostridium difficile infection (CDI) drug fidaxomicin is a natural polyketide metabolite mainly produced by Micromonosporaceae, such as Actinoplanes deccanensis, Dactylosporangium aurantiacum, and Micromonospora echinospora. In the present
Externí odkaz:
https://doaj.org/article/77bd29f45cf24682930b4e3df50f7cb0
Publikováno v:
Synthetic and Systems Biotechnology, Vol 9, Iss 1, Pp 127-133 (2024)
The biological signaling molecule nitric oxide (NO) has recently emerged as a metabolic precursor for the creation of microbial natural products with diversified structures and biological activities. Within the biosynthetic gene clusters (BGCs) of th
Externí odkaz:
https://doaj.org/article/c91d3a99a74443778b4f6b8016d0af7e
Autor:
Zhijie Zhao, Guiyun Zhao, Yi Chai, Wei Li, Kaihui Song, Wenbin Zhao, Hairong Li, Miaolian Wu, Zhan Zhou, Yi-Ling Du
Publikováno v:
Synthetic and Systems Biotechnology, Vol 8, Iss 3, Pp 520-526 (2023)
Microbial natural products have been one of the most important sources for drug development. In the current postgenomic era, sequence-driven approaches for natural product discovery are becoming increasingly popular. Here, we develop an effective gen
Externí odkaz:
https://doaj.org/article/6587d1fe69834ebc94768e443054326b
Autor:
Huang Xie, Jing-Yi Ruan, Qing-Ting Bu, Yue-Ping Li, Yi-Ting Su, Qing-Wei Zhao, Yi-Ling Du, Yong-Quan Li
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT Fidaxomicin is an 18-membered glycosidic macrolide polyketide that was clinically used in the treatment of Clostridium difficile infection in 2011. Although the biosynthetic mechanism and pathway-specific regulator of fidaxomicin were well e
Externí odkaz:
https://doaj.org/article/aeb9e410ed2f4fc6931b851f294df1b3
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Enzymes involved in the synthesis of nitrogen-nitrogen bond containing molecules have been identified but the processes remain largely unknown. Here, the authors use biochemical characterisation and computer modelling to study the molecular basis of
Externí odkaz:
https://doaj.org/article/6745aea26d19480dbc33662533473e1f
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
How nature creates 1,2,3-triazole ring is a relevant question to N-N bond biosynthesis. Here, the authors report the biosynthetic route to the triazole-bearing antimetabolite 8-azaguanine and reveal that this can be assembled through an enzymatic and
Externí odkaz:
https://doaj.org/article/dc2b67cb367840399d4e3e65ee938fac
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Azoxy bonds are frequently found in liquid crystals, chemical intermediates, dyes, agrochemicals and pharmaceuticals. Here, the authors investigated azoxy bond formation by the non-heme diiron N-oxygenase AzoC in azoxymycin biosynthesis and show that
Externí odkaz:
https://doaj.org/article/226e496179d24ce0b09894bc7d0f768e
Autor:
Lian-Hua Xu, Yi-Ling Du
Publikováno v:
Synthetic and Systems Biotechnology, Vol 3, Iss 4, Pp 283-290 (2018)
The cytochrome P450 enzymes are ubiquitous heme-thiolate proteins performing regioselective and stereoselective oxygenation reactions in cellular metabolism. Due to their broad substrate scope and catalytic versatility, P450 enzymes are also attracti
Externí odkaz:
https://doaj.org/article/d653a8c3dba240a9b05fe10212a9d873
Autor:
Mingming Qi, Bei Zhang, Lihong Jiang, Saijuan Xu, Chang Dong, Yi-Ling Du, Zhan Zhou, Lei Huang, Zhinan Xu, Jiazhang Lian
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2021)
The introduction of multi-gene metabolic pathways is generally the first step for the construction of microbial cell factories and plays an essential role in metabolic engineering and synthetic biology. Here, we developed a “PCR & Go” system for
Externí odkaz:
https://doaj.org/article/10a8a54bec8b4eb9a588ee4e052568f9
Publikováno v:
Organic Letters. 25:2918-2922
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9350dcc51694bb145271efb0057bf6a0
https://doi.org/10.1021/acs.orglett.3c01000
https://doi.org/10.1021/acs.orglett.3c01000