Výsledky vyhledávání - "Yi-Kun Chiang"

Akademický článek

A porphodimethene chemical inhibitor of uroporphyrinogen decarboxylase.

Autor: Kenneth W Yip, Zhan Zhang, Noriko Sakemura-Nakatsugawa, Jui-Wen Huang, Nhu Mai Vu, Yi-Kun Chiang, Chih-Lung Lin, Jennifer Y Y Kwan, Shijun Yue, Yulia Jitkova, Terence To, Payam Zahedi, Emil F Pai, Aaron D Schimmer, Jonathan F Lovell, Jonathan L Sessler, Fei-Fei Liu

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e89889 (2014)

Uroporphyrinogen decarboxylase (UROD) catalyzes the conversion of uroporphyrinogen to coproporphyrinogen during heme biosynthesis. This enzyme was recently identified as a potential anticancer target; its inhibition leads to an increase in reactive o

Externí odkaz: https://doaj.org/article/3e027cbf7a0a41b8af23dcfa46ce69cd

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Dissertation/ Thesis

Practice Study of Public Participation of Zone Exprepriation－Case of the Specitic Area Construction Plan in Taoyuan Aerotropolis

Autor: Yi-Kun Chiang, 姜義坤

104
Zone expropriation, is the country within a certain range to obtain land and whom administrative sanctions, such actions affect the basic constitutional rights of the property, so that the people''s property rights are violated, especially a

Externí odkaz: http://ndltd.ncl.edu.tw/handle/ehmx3f

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(1,3-Diphenyl-1H-Pyrazol-4-yl)-Methylamine Analogues as Inhibitors of Dipeptidyl Peptidases

Autor: Yi-Kun Chiang, Ting-Yueh Tsai, Chia-Hui Chien, Chung-Yu Huang, Kai-Chia Yeh, Tsu Hsu, Min-Hsien Wang, Ssu-Hui Wu, Yu-Sheng Chao, Yu-Wen Huang, Weir-Torn Jiaang, Xin Chen, Chung-Nien Chang, Chiung-Tong Chen, Su-Ying Wu, Chen-Lung Huang, Jai-Hong Cheng

Publikováno v: Journal of the Chinese Chemical Society. 56:1048-1055

A number of pyrazole compounds reported in literatures elicit anti-hyperglycemic effects. By modifying the side chain of the heterocyclic skeleton, a new chemical class of DPP-IV inhibitors structurally derived from the (pyrazol-4-yl)-methylamine sca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2fae6f1ae48fa35e75a61b61eff05179
https://doi.org/10.1002/jccs.200900152

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Generation of Ligand-Based Pharmacophore Model and Virtual Screening for Identification of Novel Tubulin Inhibitors with Potent Anticancer Activity

Autor: Ping-Chiang Lyu, Ching-Chuan Kuo, Ming-Hsine Wu, Yu-Shan Wu, Jen-Shin Song, Jiun-Shyang Leou, Huan-Yi Jseng, Su-Ying Wu, Hsing Pang Hsieh, Chi-Yen Chang, Yu-Sheng Chao, Chung-Tong Chen, Jang Yang Chang, Yi-Kun Chiang, Jian-Sung Wu, Mohane Selvaraj Coumar

Publikováno v: Journal of Medicinal Chemistry. 52:4221-4233

A pharmacophore model, Hypo1, was built on the basis of 21 training-set indole compounds with varying levels of antiproliferative activity. Hypo1 possessed important chemical features required for the inhibitors and demonstrated good predictive abili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd366b3cf3e69c02a6140e6ca22457b
https://doi.org/10.1021/jm801649y

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A porphodimethene chemical inhibitor of uroporphyrinogen decarboxylase

Autor: Jui Wen Huang, Jonathan F. Lovell, Kenneth W. Yip, Shijun Yue, Terence To, Jennifer Y. Y. Kwan, Noriko Sakemura-Nakatsugawa, Aaron D. Schimmer, Nhu Mai Vu, Yi Kun Chiang, Yulia Jitkova, Lin Chih-Lung, Payam Zahedi, Emil F. Pai, Fei-Fei Liu, Jonathan L. Sessler, Zhan Zhang

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e89889 (2014)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ef30ec4f8347b68fdd36af64eeeea0
http://europepmc.org/articles/PMC3934957?pdf=render

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Synthesis and evaluation of 3-aroylindoles as anticancer agents: metabolite approach

Publikováno v: Journal of medicinal chemistry. 52(15)

BPR0L075 (2) is a potential anticancer drug candidate designed from Combretastatin A-4 (1) based on the bioisosterism principle. Metabolites of 2, proposed from in vitro human microsome studies, were synthesized, leading to the identification of meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::537ac34fa49b095db12ac1bad9a25dcd
https://pubmed.ncbi.nlm.nih.gov/19586033

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Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents

Autor: Mohane Selvaraj Coumar, Chi-Yen Chang, Yi-Kun Chiang, Ching-Chuan Kuo, Uan-Kang Tan, Su-Ying Wu, Jiann-Yih Yeh, Mei-Jung Lai, Hsing Pang Hsieh, Jang Yang Chang, Jing Ping Liou, Gadarla Randheer Reddy

Publikováno v: Journal of medicinal chemistry. 51(24)

A series of aroylnaphthalene derivatives were prepared as bioisosteres of combrestatin A-4 and evaluated for anticancer activity. 2-Amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalene, 9 and 8, respectively, showed strong antiproliferative acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d234a7c92fa90567537f20661ee0ba2b
https://pubmed.ncbi.nlm.nih.gov/19053773

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A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitors

Autor: Yi-Kun Chiang, Yu-Sheng Chao, Chia-Hui Chien, Su-Ying Wu, Neeraj Mahindroo, Weir-Torn Jiaang, I-Lin Lu, Xin Chen, Keng-Chang Tsai, Shiow-Ju Lee, Ssu-Hui Wu

Publikováno v: European journal of medicinal chemistry. 43(8)

Dipeptidyl peptidase IV (DPP-IV) is a valid drug target for type-2 diabetes and DPP-IV inhibitors have been proven to efficiently improve glucose tolerance. In our study, 3D pharmacophore models were generated using a training set of 22 DPP-IV inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aecfca4b29be85196b0a9446105be49
https://pubmed.ncbi.nlm.nih.gov/18207285

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