Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Yi-Kai Chiu"'
Autor:
Hung-Ju Hsu, Chao-Ping Tung, Chung-Ming Yu, Chi-Yung Chen, Hong-Sen Chen, Yu-Chuan Huang, Pei-Hsun Tsai, Su-I Lin, Hung-Pin Peng, Yi-Kai Chiu, Yueh-Liang Tsou, Wei-Ying Kuo, Jhih-Wei Jian, Fei-Hung Hung, Chiao-Yun Hsieh, Michael Hsiao, Simon Shih-Hsien Chuang, Chia-Ning Shen, Yong Alison Wang, An-Suei Yang
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Mesothelin (MSLN) is an attractive candidate of targeted therapy for several cancers, and hence there are increasing needs to develop MSLN-targeting strategies for cancer therapeutics. Antibody–drug conjugates (ADCs) targeting MSLN have be
Externí odkaz:
https://doaj.org/article/1fd9e8c33c85491783497a53a3cfc809
Autor:
Zu-Chian Chiang, Yi-Kai Chiu, Cheng-Chung Lee, Nai-Shu Hsu, Yueh-Liang Tsou, Hong-Sen Chen, Horng-Ru Hsu, Tzung-Jie Yang, An-Suei Yang, Andrew H-J Wang
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0239813 (2020)
Two systems of antibody-drug conjugates (ADCs), noncleavable H32-DM1 and cleavable H32-VCMMAE, were developed by using different linkers and drugs attached to the anti-HER2 antibody H32, which is capable of cell internalization. Activated functional
Externí odkaz:
https://doaj.org/article/5d6f3f7fe5e14ac4956c0545a6f64839
Autor:
Yi-Kai Chiu, 邱奕凱
102
ABF-1, a basic helix loop helix (bHLH) transcriptional repressor, is expressed in human activated B cells and Hodgkin’s lymphoma. The role of ABF-1 in Hodgkin’s lymphoma is to silence the expression of B cell specific genes by antagonizi
ABF-1, a basic helix loop helix (bHLH) transcriptional repressor, is expressed in human activated B cells and Hodgkin’s lymphoma. The role of ABF-1 in Hodgkin’s lymphoma is to silence the expression of B cell specific genes by antagonizi
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/51448569399174973996
Autor:
Yi-Kai Chiu, 邱奕凱
89
Asthma is a complex syndrome with many clinical phenotypes in both adults and children. Its major characteristics include a variable degree of bronchial hyper-response and with airway obstruction inflammation. Both genetic factors and environ
Asthma is a complex syndrome with many clinical phenotypes in both adults and children. Its major characteristics include a variable degree of bronchial hyper-response and with airway obstruction inflammation. Both genetic factors and environ
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/61789937941854068056
Autor:
Yi-Kai Chiu, 邱翌凱
100
Knowledge is an important resource for organizations to create their value. Many managers and scholars also pointed out that employees’ knowledge sharing attitude is one of the key elements of knowledge management. In addition, managers al
Knowledge is an important resource for organizations to create their value. Many managers and scholars also pointed out that employees’ knowledge sharing attitude is one of the key elements of knowledge management. In addition, managers al
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/13965559228493067205
Autor:
Wei Ying Kuo, Hung Ju Hsu, Andrew H.-J. Wang, Chao Ping Tung, Yi Kai Chiu, An-Suei Yang, Yu Chi Chou, Chung Ming Yu, Jhih-Wei Jian, Ing Chien Chen, Hong Sen Chen, Chun Yi Wu, Yong Alison Wang, Michael Hsiao, Hung-Pin Peng, Chia Lung Lin, Yueh Liang Tsou
Publikováno v:
mAbs
HER2-ECD (human epidermal growth factor receptor 2 – extracellular domain) is a prominent therapeutic target validated for treating HER2-positive breast and gastric cancer, but HER2-specific therapeutic options for treating advanced gastric cancer
Autor:
Shii-Yi Yang, Shin-Tang Su, Yi-Kai Chiu, Kuo-I Lin, I-Ying Lin, Kuan-Hsiung Wang, Yi-Ting Hsieh, Dong-Yan Tsai
Publikováno v:
The Journal of Immunology. 193:2207-2217
Ag-primed B cells that result from an immune response can form either memory B cells or Ab-secreting plasma cells; however, the molecular machinery that controls this cellular fate is poorly understood. In this study, we show that activated B cell fa
Plasma cell differentiation is orchestrated by the transcriptional repressor B lymphocyte-induced maturation protein-1 (Blimp-1), which silences the gene expression program of mature B cells. The molecular mechanism underlying Blimp-1 suppression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::128f8aa9fc5dc86ccb0458e355f0b82b
https://europepmc.org/articles/PMC2648243/
https://europepmc.org/articles/PMC2648243/
Autor:
Ching-Yuang Lin, Yi Kai Chiu, Duaine R. Jackola, Andreas Rosenberg, Malcolm N. Blumenthal, Carol L. Liebeler
Publikováno v:
Molecular immunology. 42(1)
The dynamics of human antigen-specific immunoglobulin (Ig) responses in early life are not well characterized. We have previously observed an inverse relationship between allergen-specific Ig concentration and allergen-Ig-binding affinity in allergen
Autor:
Chao-Yang Lai, Alice L. Yu, Wen-Bin Yang, Hsin-Hung Lin, John Yu, Kuo-I Lin, Shu-Hwa Chen, Huan-Chieh Cho, Yi-Kai Chiu
Publikováno v:
Cancer Research. 70:316-316
Triggering receptor expressed on myeloid cell (TREM) proteins are a family of receptors that regulate many different cell processes. TREM-like transcript 2 (TLT-2) is one of these TREM proteins. It have been reported that TLT-2 plays important roles