Heat shock protein 47 promotes tumor survival and therapy resistance by modulating AKT signaling via PHLPP1 in colorectal cancer

Autor: Yi-Jye Chern, Peter G. Zhang, Isabella T. Tai, Hyelim Ju

Publikováno v: Cancer Biology and Medicine. 17:343-356

Objective: Heat shock protein 47 (HSP47) is a collagen-specific molecular chaperone that facilitates collagen maturation. Its role in cancer remains largely unknown. In this study, we investigated the roles of HSP47 in colorectal cancer (CRC) and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d616ee00df94cc3b30da102f1284408
https://doi.org/10.20892/j.issn.2095-3941.2019.0261

The interaction between SPARC and GRP78 interferes with ER stress signaling and potentiates apoptosis via PERK/eIF2α and IRE1α/XBP-1 in colorectal cancer

Autor: Yi-Jye Chern, Isabella T. Tai, Angel Yu, Grace Cheng, David F. Schaeffer, Gregg B. Morin, Yaling Yin, John C. Wong, Hagen F. Kennecke

Publikováno v: Cell Death and Disease, Vol 10, Iss 7, Pp 1-14 (2019)
Cell Death & Disease

Therapy-refractory disease is one of the main contributors of treatment failure in cancer. In colorectal cancer (CRC), SPARC can function as a sensitizer to conventional chemotherapy by enhancing apoptosis by interfering with the activity of Bcl-2. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a476ecd19ea0e34201962dd176084f9
http://link.springer.com/article/10.1038/s41419-019-1687-x

The ubiquitin ligase RNF8 regulates Rho GTPases and promotes cytoskeletal changes and motility in triple-negative breast cancer cells

Autor: Chia Hsin Chan, Bruno Pereira De Carvalho, Jiabei He, Yi-Jye Chern

Publikováno v: Febs Letters

The ubiquitin ligase RNF8 is known to induce epithelial-to-mesenchymal (EMT) transition and metastasis in triple-negative breast cancer (TNBC). Besides EMT, Rho GTPases have been shown as key regulators in metastasis. In this study, we investigated t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3045d48a5264f9e25a38d91919204ee
https://pubmed.ncbi.nlm.nih.gov/33205415

Early Assessment of Colorectal Cancer by Quantifying Circulating Tumor Cells in Peripheral Blood: ECT2 in Diagnosis of Colorectal Cancer

Autor: Yi-Jye Chern, Yueh-Min Lin, Hui-Ting Hsu, Kun-Tu Yeh, Wen-Wei Sung, Shu-Hui Lin, Hung-Chang Chen, Konan Peck, Chih-Jung Chen

Publikováno v: International Journal of Molecular Sciences; Volume 18; Issue 4; Pages: 743
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 18, Iss 4, p 743 (2017)

Circulating tumor cells (CTCs) in peripheral blood is an indication of poor prognosis for patients with different cancer types. However, most of the available technologies for detecting CTCs show low sensitivity and specificity. Therefore, we attempt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05fcc36109dfc52080fece80fc190ebe

Early Assessment of Colorectal Cancer by Quantifying Circulating Tumor Cells in Peripheral Blood: ECT2 in Diagnosis of Colorectal Cancer.

Autor: Chih-Jung Chen, Wen-Wei Sung, Hung-Chang Chen, Yi-Jye Chern, Hui-Ting Hsu, Yueh-Min Lin, Shu-Hui Lin, Konan Peck, Kun-Tu Yeh

Publikováno v: International Journal of Molecular Sciences; Apr2017, Vol. 18 Issue 4, p743, 12p, 1 Diagram, 2 Charts, 3 Graphs