Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Yi-Jing Tian"'
Autor:
Yang, Jun, Jiang, Guan-Cheng, Yi, Jing-Tian, He, Yin-Bo, Yang, Li-Li, Dong, Teng-Fei, Wang, Guo-Shuai
Publikováno v:
In Petroleum Science August 2024 21(4):2677-2687
Autor:
Qian Zhou, Xixin He, Yi-Jing Tian, Jiaqi Zhu, Jinhao Liang, Yue Huang, Ziran Zhu, Yi-You Huang, Jinhui Deng, Hai-Bin Luo, Xi Xie
Publikováno v:
Journal of Medicinal Chemistry. 64:13736-13751
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease, and its incidence rate is rapidly rising. However, effective therapies for the treatment of IPF are still lacking. Phosphodiesterase 4 (PDE4) inhibitors were reported to be potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97dab0b55195d8e8e88da2d44d2ced00
https://doi.org/10.1021/acs.jmedchem.1c01085
https://doi.org/10.1021/acs.jmedchem.1c01085
Autor:
Meng-Xing Huang, Yi-Jing Tian, Chuan Han, Run-Duo Liu, Xi Xie, Yijun Yuan, Yi-Yi Yang, Zhe Li, Jianwen Chen, Hai-Bin Luo, Yinuo Wu
Publikováno v:
Journal of medicinal chemistry. 65(12)
Our previous research demonstrated that phosphodiesterase-1 (PDE1) could work as a potential target against idiopathic pulmonary fibrosis. Nimodipine, a calcium antagonist commonly used to improve hypertension, was reported to have inhibition against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41d4148a9bac86eb1401445d662f4ab3
https://pubmed.ncbi.nlm.nih.gov/35666471
https://pubmed.ncbi.nlm.nih.gov/35666471
Autor:
Yuqi Gao, Qian Zhou, Meiying Qiu, Deyan Wu, Lei Guo, Yue Huang, Hai-Bin Luo, Yi-Jing Tian, Yi-You Huang
Publikováno v:
RSC advances. 11(51)
Small molecule fluorescent probes provide a powerful labelling technology to enhance our understanding of particular proteins. However, the discovery of a proper fluorescent probe for detecting PDE5 is still a challenge due to the highly conservative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf82861bb3753d37bec945210c3908b
https://pubmed.ncbi.nlm.nih.gov/35495504
https://pubmed.ncbi.nlm.nih.gov/35495504
Autor:
Bei Zhang, Yi-Jing Tian, Yinuo Wu, Yi-You Huang, Mei-Yan Jiang, Ziran Zhu, Chuan Han, Hai-Bin Luo, Quan Wang
Publikováno v:
Journal of medicinal chemistry. 64(13)
Hepatic fibrosis commonly exists in chronic liver disease and would eventually develop to cirrhosis and liver cancer with high fatality. Phosphodiesterase-9 (PDE9) has attracted profound attention as a drug target because of its highest binding affin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01f15243f0cc94c32143a653ef17c09
https://pubmed.ncbi.nlm.nih.gov/34142552
https://pubmed.ncbi.nlm.nih.gov/34142552
Autor:
Chen Zhang, Mei-Ling Le, Yi-Jing Tian, Mei-Yan Jiang, Hai-Bin Luo, Bei Zhang, Sirui Zhang, Meng-Xing Huang, Yinuo Wu
Publikováno v:
Journal of medicinal chemistry. 63(14)
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and devastating lung disease lacking effective therapy. To identify whether phosphodiesterase-1 (PDE1) inhibition could act as a novel target for the treatment of IPF, hit-to-lead structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e84e89dda7a315df1a6724f1897636a
https://pubmed.ncbi.nlm.nih.gov/32603117
https://pubmed.ncbi.nlm.nih.gov/32603117
Autor:
Fang-Yu Yuan, Sheng Yin, Xu Zhang, Run-Zhu Fan, Xue-Long Yan, Qin-Feng Zhu, Yang Tian, Yi-Jing Tian, Gui-Hua Tang, Dong Huang, Yan Lin, Lu Gan, Shen Li
Publikováno v:
Bioorganic Chemistry. 114:105222
Seven new diterpenoids, eupholenes A-G (1-7), including two presegetanes (1 and 2), four jatrophanes (3-6), and one paraliane (7), along with 19 known analogues (8-26) were obtained by anti-liver fibrosis bioassay-guided isolation of Euphorbia siebol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78bb7aa22549898ad4413ecaa996594b
https://doi.org/10.1016/j.bioorg.2021.105222
https://doi.org/10.1016/j.bioorg.2021.105222
Publikováno v:
Bioorganic chemistry. 95
Twenty new ingol diterpenoids, euphornans A–T (1–20), representing a rare class of C-19-oxidated and H-2, H-3 β-oriented ingols, were isolated from the seeds of Euphorbia marginata. Their structures including absolute configurations were elucida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d16ebca3248b5f9153d5044143bd5c46
https://pubmed.ncbi.nlm.nih.gov/31911302
https://pubmed.ncbi.nlm.nih.gov/31911302
Autor:
Yinuo Wu, Qian Zhou, Yan-Fa Yu, Chen Jianwen, Yi-Jing Tian, Zhe Li, Pei Zhang, Yiping Chen, Yu Wang, Yan Chen, Haiju Geng, Chen Zhang, Hai-Bin Luo, Tianhua Zhang
Publikováno v:
Journal of medicinal chemistry. 62(8)
To identify phosphodiesterase-9 (PDE9) as a novel target for the treatment of vascular dementia (VaD), a series of pyrazolopyrimidinone analogues were discovered based on a hit 1. Hit-to-lead optimization resulted in a potent inhibitor 2 with excelle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf84841062fddfdf5e0323b643d122d6
https://pubmed.ncbi.nlm.nih.gov/30916555
https://pubmed.ncbi.nlm.nih.gov/30916555
Autor:
Hang Li, Depo Yang, Dongmei Wang, Zhimin Zhao, Long-Ping Zhu, Shi-Yi Peng, Bai Bai, Yi-Jing Tian, Chun-You Mu
Publikováno v:
Chirality. 28:259-263
One pair of new C-8-C-3'/C-7-O-C-4' linked neolignan enantiomers (1a/1b) and one new guaiane sesquiterpene (2) first featuring the 1(2),9(10)-conjugated double bond were isolated from the stems of Solanum erianthum (Solanceae). Their structures were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91923ddcd162b87d6df3165e39f9a492
https://doi.org/10.1002/chir.22571
https://doi.org/10.1002/chir.22571