Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Yi-Jen Liao"'
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 273, Iss , Pp 116161- (2024)
Di(2-ethylhexyl) phthalate (DEHP) is a worldwide common plasticizer. Nevertheless, DEHP is easily leached out to the environment due to the lack of covalent bonds with plastic. High dose of DEHP exposure is often observed in hemodialysis patients bec
Externí odkaz:
https://doaj.org/article/9c5ae673a6754ce5b9e02decea97f485
Autor:
Yi-Jen Liao, Chun-Ya Lee, Yuh-Ching Twu, Fat-Moon Suk, Tzu-Chieh Lai, Ya-Ching Chang, Yi-Cheng Lai, Jing-Wei Yuan, Hong-Ming Jhuang, Huei-Ruei Jian, Li-Chia Huang, Kuang-Po Chen, Ming-Hua Hsu
Publikováno v:
Bioengineering, Vol 10, Iss 9, p 1075 (2023)
The increased proliferation and activation of hepatic stellate cells (HSCs) are associated with liver fibrosis development. To date, there are no FDA-approved drugs for the treatment of liver cirrhosis. Augmentation of HSCs apoptosis is one of the re
Externí odkaz:
https://doaj.org/article/bed4ef76c68a40bd989fc335a61adef8
Publikováno v:
Molecular Therapy: Oncolytics, Vol 17, Iss , Pp 571-585 (2020)
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a 5-year survival rate of 9%. Major obstacles to successful treatment of pancreatic cancer are the immunosuppressive tumor microenvironment (TME) and antigenic complexity or hetero
Externí odkaz:
https://doaj.org/article/3eb61f68d3cd4091bfbc24084b804085
Publikováno v:
Molecules, Vol 27, Iss 22, p 8015 (2022)
Primary liver cancer is the fifth leading death of cancers in men, and hepatocellular carcinoma (HCC) accounts for approximately 90% of all primary liver cancer cases. Sorafenib is a first-line drug for advanced-stage HCC patients. Sorafenib is a mul
Externí odkaz:
https://doaj.org/article/58d842b9d31641f2aea0db9d1e82d3fa
Autor:
Yuan-Hsi Wang, Fat-Moon Suk, Chao-Lien Liu, Tzu-Lang Chen, Yuh-Ching Twu, Ming-Hua Hsu, Yi-Jen Liao
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Hepatic stellate cells (HSCs) are the major profibrogenic cells that promote the pathogenesis of liver fibrosis. The crosstalk between transforming growth factor-β1 (TGF-β1) signaling and lipopolysaccharide (LPS)-induced NF-κB signaling plays a cr
Externí odkaz:
https://doaj.org/article/ccbc78ac3d6d44d0a03ba68121acccde
Autor:
Chia-Hung Yen, Chih-Chung Lai, Chen-Chung Liao, Sheng-Fan Wang, Yi-Jen Liao, Chien-Yi Tung, Jung-Hsien Hung, Shiu-Feng Huang, Yi-Ming Arthur Chen
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Sarcomatoid hepatocellular carcinoma (SHC) is a rare type of HCC with significantly poorer survival than ordinary HCC. Little is known about the mechanism associated with SHC and its biomarkers and therapy. Here, we established a mouse liver
Externí odkaz:
https://doaj.org/article/7fc683ec0bfb40a7af09f8ebb59e314f
Publikováno v:
Life, Vol 10, Iss 10, p 246 (2020)
To investigate the association of immunosenescence with aged-related morbidity in the elderly, a clinical study was conducted to analyze and compare the alterations in peripheral blood (PB) T-cell subsets among young healthy (YH) controls, elderly he
Externí odkaz:
https://doaj.org/article/b29382beddaa4fe1ad73a19a38b98bff
Publikováno v:
Applied Sciences, Vol 10, Iss 17, p 5941 (2020)
Liver fibrosis initiates the progression of cirrhosis, and, finally, hepatocellular carcinoma (HCC). The increased proliferation and activation of hepatic stellate cells (HSCs) are crucial for hepatic fibrogenesis. Paeonol is the major vigorous compo
Externí odkaz:
https://doaj.org/article/bcd162b5c6464a3f84f5728eb4b797fe
Publikováno v:
Molecules, Vol 25, Iss 12, p 2856 (2020)
Hepatocellular carcinoma (HCC) is a common cause of cancer death worldwide. Sorafenib, a multikinase inhibitor, is the first-line drug approved by the Food and Drug Administration (FDA) for the treatment of patients with advanced HCC. However, most p
Externí odkaz:
https://doaj.org/article/ef677613825242e99da6c1a218bb0796
Autor:
Yu-Ting Lin, Chia-Hung Yen, Heng-Li Chen, Yi-Jen Liao, I-Feng Lin, Marcelo Chen, Yu-Ching Lan, Shao-Yuan Chuang, Shie-Liang Hsieh, Yi-Ming Arthur Chen
Publikováno v:
Journal of the Formosan Medical Association, Vol 114, Iss 6, Pp 498-503 (2015)
The decoy receptor 3 (DcR3) is a member of the tumor necrosis factor receptor (TNFR) super-family. It counteracts the biological effects of Fas ligands and inhibits apoptosis. The goals of this study were to understand the associations between serolo
Externí odkaz:
https://doaj.org/article/be099177ed084455b5c725e48e909bbf