Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Yi-Jang Lin"'
Autor:
Kevin M. Haigis, Kenneth D. Westover, Douglas A. Lauffenburger, Steven P. Gygi, Benjamin S. Braun, Pedro A. Perez-Mancera, John R. Engen, Yina Li, Jessica J. Gierut, Lana Bogdanova, Roxana E. Iacob, Thomas E. Wales, Sudershan Gondi, Phaedra C. Ghazi, Rebecca A. DeStefanis, Christian W. Johnson, Brian A. Joughin, Douglas K. Brubaker, Jonathan A. Nowak, Joshua Cook, Wei Yan, Carolina Morales, Tannie Q. Huang, Joao A. Paulo, Samantha Dale Strasser, Yi-Jang Lin, Jia Lu, Asim K. Bera, Emily J. Poulin
Proteomics data from human cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2426b866d556530901ce4ab6f469c7a7
https://doi.org/10.1158/2159-8290.22532587
https://doi.org/10.1158/2159-8290.22532587
Autor:
Kevin M. Haigis, Kenneth D. Westover, Douglas A. Lauffenburger, Steven P. Gygi, Benjamin S. Braun, Pedro A. Perez-Mancera, John R. Engen, Yina Li, Jessica J. Gierut, Lana Bogdanova, Roxana E. Iacob, Thomas E. Wales, Sudershan Gondi, Phaedra C. Ghazi, Rebecca A. DeStefanis, Christian W. Johnson, Brian A. Joughin, Douglas K. Brubaker, Jonathan A. Nowak, Joshua Cook, Wei Yan, Carolina Morales, Tannie Q. Huang, Joao A. Paulo, Samantha Dale Strasser, Yi-Jang Lin, Jia Lu, Asim K. Bera, Emily J. Poulin
Supplementary Figures S1-S18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea23cd43399e8b35ccc18f1cea0e40ed
https://doi.org/10.1158/2159-8290.22532605
https://doi.org/10.1158/2159-8290.22532605
Autor:
Kevin M. Haigis, Kenneth D. Westover, Douglas A. Lauffenburger, Steven P. Gygi, Benjamin S. Braun, Pedro A. Perez-Mancera, John R. Engen, Yina Li, Jessica J. Gierut, Lana Bogdanova, Roxana E. Iacob, Thomas E. Wales, Sudershan Gondi, Phaedra C. Ghazi, Rebecca A. DeStefanis, Christian W. Johnson, Brian A. Joughin, Douglas K. Brubaker, Jonathan A. Nowak, Joshua Cook, Wei Yan, Carolina Morales, Tannie Q. Huang, Joao A. Paulo, Samantha Dale Strasser, Yi-Jang Lin, Jia Lu, Asim K. Bera, Emily J. Poulin
Data collection and refinement statistics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f8366377fb78585b44b56e2021cd08
https://doi.org/10.1158/2159-8290.22532602
https://doi.org/10.1158/2159-8290.22532602
Autor:
Nicolas A. Gort-Freitas, Christina Pfirschke, Anna Kohl, Doron Merkler, Marie Siwicki, Yoshiko Iwamoto, Chiara Cianciaruso, Rapolas Zilionis, Marius Messemaker, Sara I. Pai, John E. Mindur, Montserrat Fraga, Pierre-Yves Dietrich, Angela E. Zou, Alexander Coukos, Christine Sempoux, Yi-Jang Lin, Nilesh Talele, Cecile Piot, Thibaud Koessler, Alexandre Wicky, Rakesh K. Jain, Yunkang Lin, Mikael J. Pittet, Rainer H. Kohler, Ruben Bill, Christopher Garris, Camilla Engblom, Jeremy Gungabeesoon, Allon M. Klein, Claudio deVito, Olivier Michielin, Ralph Weissleder, Evangelia Bolli, Genevieve M. Gerhard, Mari Mino-Kenudson
Publikováno v:
Sci Immunol
Science Immunology, Vol. 6, No 61 (2021) P. eabi7083
Science Immunology, Vol. 6, No 61 (2021) P. eabi7083
Immunotherapy is revolutionizing cancer treatment but is often restricted by toxicities. What distinguishes adverse events from concomitant antitumor reactions is poorly understood. Here, using anti-CD40-treatment in mice as a model of Th1-promoting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b9db22b1b089ff465f17caa910096aa
https://doi.org/10.1126/sciimmunol.abi7083
https://doi.org/10.1126/sciimmunol.abi7083
Autor:
Christian W. Johnson, Pedro A. Perez-Mancera, Steven P. Gygi, Joshua Cook, Benjamin S. Braun, Jessica J. Gierut, Samantha Dale Strasser, Douglas K. Brubaker, Jonathan A. Nowak, Brian A. Joughin, Rebecca A. Destefanis, Kenneth D. Westover, John R. Engen, Lana Bogdanova, Kevin M. Haigis, Carolina Morales, Emily J. Poulin, Jia Lu, Yi Jang Lin, Phaedra C. Ghazi, Asim K. Bera, Joao A. Paulo, Yina Li, Thomas E. Wales, Wei Yan, Sudershan R. Gondi, Roxana E. Iacob, Tannie Q. Huang, Douglas A. Lauffenburger
Publikováno v:
Cancer Discov
CANCER DISCOVERY
PMC
CANCER DISCOVERY
PMC
KRAS is the most frequently mutated oncogene. The incidence of specific KRAS alleles varies between cancers from different sites, but it is unclear whether allelic selection results from biological selection for specific mutant KRAS proteins. We used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f87a5e50f6b926f0042b2b594d2960
https://europepmc.org/articles/PMC6548671/
https://europepmc.org/articles/PMC6548671/
Autor:
Christian W. Johnson, Carla Mattos, Jillian A. Parker, Kevin M. Haigis, Carrie R. Graveel, Derion Reid, Patrick S. Dischinger, Spiro Pavlopoulos, Yi-Jang Lin, Matthew Steensma
Publikováno v:
SSRN Electronic Journal.
Ras GTPases are mutated at codons 12, 13 and 61 with different frequencies in KRas, HRas and NRas and in a cancer-specific manner. The G13D mutant appears in 25% of KRas driven colorectal cancers, while observed only rarely in HRas or NRas. Structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2e128fce94395c902cfabc16c2a4494
https://doi.org/10.2139/ssrn.3312728
https://doi.org/10.2139/ssrn.3312728
Publikováno v:
Molecular Cancer Research. 18:A18-A18
The K-RAS (Kirsten rat sarcoma) oncoprotein is mutationally activated in ~40% of colorectal cancers (CRCs), and K-RAS mutation state is an excellent predictor of the failure of a cancer to respond to conventional chemotherapy or targeted therapy. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1437f8e16bcf07f46a618d66313e2289
https://doi.org/10.1158/1557-3125.ras18-a18
https://doi.org/10.1158/1557-3125.ras18-a18
Autor:
Jesse Lyons, Wilhelm Haas, Douglas K. Brubaker, Douglas A. Lauffenburger, Myriam Boukhali, Phaedra C. Ghazi, Samantha Dale Strasser, Joseph L. Kissil, Amanda L. Edwards, Lucia Suarez-Lopez, Yi-Jang Lin, Kevin M. Haigis, Vijay Yajnik, Katherine R. Baldwin
Publikováno v:
Prof. Lauffenburger via Howard Silver
Inflammatory bowel disease (IBD) is a chronic disorder of the gastrointestinal tract that has limited treatment options. To gain insight into the pathogenesis of chronic colonic inflammation (colitis), we performed a multiomics analysis that integrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aff36b977c78388e604a0cf6dfbcd291
https://pubmed.ncbi.nlm.nih.gov/29487189
https://pubmed.ncbi.nlm.nih.gov/29487189
Autor:
David T. Scadden, Steffen Rickelt, Virginia Savova, Julien Faget, Ferdinando Pucci, Marie B. Demay, Camilla Engblom, Christina Pfirschke, Hsin-Wei Liao, Yoshiko Iwamoto, Marie Siwicki, Gabriel Courties, Omar K. Yaghi, Benoit Tricot, Richard O. Hynes, Mikael J. Pittet, David Zemmour, Rapolas Zilionis, Matthias Nahrendorf, Virna Cortez-Retamozo, Yi Jang Lin, Nicolas Severe, Janaina S. Martins, Christopher Garris, Allon M. Klein, Etienne Meylan, Andita Newton, Jaclyn Kline, Gregory R. Wojtkiewicz, Ninib Baryawno, Ralph Weissleder, Miriam A. Bredella, Stijn A. Bos
Publikováno v:
Science
Science, American Association for the Advancement of Science, 2017, 358 (6367), pp.eaal5081. ⟨10.1126/science.aal5081⟩
Science, Vol. 358, No 6367 (2017) P. eaal5081
Science, American Association for the Advancement of Science, 2017, 358 (6367), pp.eaal5081. ⟨10.1126/science.aal5081⟩
Science, Vol. 358, No 6367 (2017) P. eaal5081
A bona fide portrayal of tumor growth Bone has a well-established role in advanced cancer. It provides a supportive microenvironment for the growth of metastatic cells that escape the primary tumor, which ultimately leads to loss of bone mass. Engblo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db09dc1b3b63613ff497e5ca16c80eba
https://hal.umontpellier.fr/hal-02443950
https://hal.umontpellier.fr/hal-02443950
Autor:
Zi-Ming Huang, Yi-Jang Lin, Chiun Hsu, Anita Gandhi, Yung-Ming Jeng, Chun-Jung Chang, Da-Liang Ou, Zhong-Zhe Lin, Ann-Lii Cheng, Sheng-Chieh Liao
Publikováno v:
Journal of Gastroenterology and Hepatology. 29:2021-2031
Background and Aim The immune modulatory drug lenalidomide has shown promising anti-tumor activity in a clinical trial of patients with advanced hepatocellular carcinoma (HCC). The present study explored whether lenalidomide can enhance the anti-tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9630fcf5f038e2fabff2e34d88aa069e
https://doi.org/10.1111/jgh.12708
https://doi.org/10.1111/jgh.12708