Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Yi-Hsun Chang"'
Autor:
Chi-Ching Hwang, Yi-Hsun Chang, Hwei-Jen Lee, Tzu-Pin Wang, Yu-Mei Su, Hsin-Wei Chen, Po-Huang Liang
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63594 (2013)
3α-Hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni reversibly catalyzes the oxidation of androsterone with NAD(+) to form androstanedione and NADH. Structurally the substrate-binding loop of the residues, T188-K208, is un
Externí odkaz:
https://doaj.org/article/5d21877c0bad475fb497996253eccd6d
Autor:
Yi-Hsun Chang, 張藝薰
106
Affected by the economic downturn in recent years, the number of entrepreneurs increases day by day, the size of new venture creation are mostly micro-enterprises. This paper uses the Timmons model as the research framework to research how t
Affected by the economic downturn in recent years, the number of entrepreneurs increases day by day, the size of new venture creation are mostly micro-enterprises. This paper uses the Timmons model as the research framework to research how t
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/mvg7v9
Autor:
Yi-hsun Chang, 張以洵
98
This paper proposes a keyword-based search approach based on search similarity in unstructured peer-to-peer networks. Peers extract the keyword terms from object names as the objects’ features. With the feature similarity among peers’ obj
This paper proposes a keyword-based search approach based on search similarity in unstructured peer-to-peer networks. Peers extract the keyword terms from object names as the objects’ features. With the feature similarity among peers’ obj
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/79458059791255787765
Autor:
Yi-Hsun Chang, 張藝薰
98
3alpha-hydroxysteroid dehydrogenase/carbonyl reductase (3alpha-HSD/CR) from Comamonas testosteroni catalyzes the oxidation of androsterone with NAD+ to form androstanedione and NADH. According to the sequence alignment and structure analysis,
3alpha-hydroxysteroid dehydrogenase/carbonyl reductase (3alpha-HSD/CR) from Comamonas testosteroni catalyzes the oxidation of androsterone with NAD+ to form androstanedione and NADH. According to the sequence alignment and structure analysis,
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/98601101131610947073
Autor:
Ko Jiunn Liu, Chien Chang Huang, Yi Hsun Chang, Chang Po Kuo, Chun-Cheng Lin, Yung Ning Yang, Wun Shaing Wayne Chang, Jang Yang Chang, Ching Chuan Kuo, Chun Hei Antonio Cheung, Ching Ming Wu, Kuo Li Chen
Publikováno v:
Cancer Letters. 317:89-98
Cathepsin S is a cellular cysteine protease, which is frequently over-expressed in human cancer cells and plays important role in tumor metastasis. However, the role of cathepsin S in regulating cancer cell survival and death remains undefined. The a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1020b38b0b2532c60f627e21ac7960e
https://doi.org/10.1016/j.canlet.2011.11.015
https://doi.org/10.1016/j.canlet.2011.11.015
Autor:
Ching Chuan Kuo, Jo Chun Chen, Ping-Chiang Lyu, Hsin Chieh Wang, Chun-Cheng Lin, Biing-Jiun Uang, Margaret Dah-Tsyr Chang, Wun Shaing Wayne Chang, Ko Jiunn Liu, Yi Hsun Chang, Jang Yang Chang, Hsing Pang Hsieh, Chao Sheng Cheng
Publikováno v:
Journal of Medicinal Chemistry. 53:4545-4549
A series of small molecules bearing an alpha-ketoamide warhead were synthesized and evaluated for their ability to inhibit cathepsin S, a key proteolytic enzyme upregulated in many cancers during tumor progression and metastasis. Most of the syntheti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ece824a9b875060a04a896012a58e3
https://doi.org/10.1021/jm100089e
https://doi.org/10.1021/jm100089e
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1804:235-241
3alpha-Hydroxysteroid dehydrogenase/carbonyl reductase reversely catalyzes the oxidation of androsterone with NAD(+) to form androstanedione and NADH. In this study, we investigated the function of active site residues N86, Y155, and K159 in NADH bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd415d7d1b05ecfbe2843ae03077c22f
https://doi.org/10.1016/j.bbapap.2009.10.012
https://doi.org/10.1016/j.bbapap.2009.10.012
Publikováno v:
Molecular Biotechnology. 44:133-139
Human 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) catalyzes the reaction of estrone with NADPH to form estradiol and NADP(+), thereby regulating the biological activity of sex steroid hormones in a variety of tissues. Here, we present an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85aa90d0a9709b5c835d5b97f1c445d2
https://doi.org/10.1007/s12033-009-9221-5
https://doi.org/10.1007/s12033-009-9221-5
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1794:1459-1466
3α-Hydroxysteroid dehydrogenase/carbonyl reductase reversibly catalyzes the oxidation of androsterone with NAD + to form androstanedione and NADH. In this study, we characterize the role of the conserved residue S114 in cofactor binding and catalysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a80c8004bfd6e172290d9497d0c5c9
https://doi.org/10.1016/j.bbapap.2009.06.006
https://doi.org/10.1016/j.bbapap.2009.06.006
Publikováno v:
Journal of Biological Chemistry. 280:3522-3528
3alpha-hydroxysteroid dehydrogenase/carbonyl reductase (3alpha-HSD/CR) from Comamonas testosteroni, a short chain dehydrogenase/reductase, catalyzes the oxidation of androsterone with NAD+ to form androstanedione and NADH. A catalytic triad of Ser-11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87462a069c395d8e406de7beb9d14f98
https://doi.org/10.1074/jbc.m411751200
https://doi.org/10.1074/jbc.m411751200