Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Yi-Di Guan"'
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
DNA repair pathways are triggered to maintain genetic stability and integrity when mammalian cells are exposed to endogenous or exogenous DNA-damaging agents. The deregulation of DNA repair pathways is associated with the initiation and progression o
Externí odkaz:
https://doaj.org/article/ed52afba1e8a40c8a72ad1497f451630
Autor:
Jun-Ju He, Zhi Li, Zhuo-Xian Rong, Jie Gao, Yun Mu, Yi-Di Guan, Xin-Xin Ren, Yu-Yuan Zi, Li-Yu Liu, Qi Fan, Ming Zhou, Yu-Mei Duan, Qin Zhou, Yue-Zhen Deng, Lun-Quan Sun
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
N6-methyladenosine (m6A) modification has been reported as a critical regulator of gene transcript expression. Although m6A modification plays important roles in tumor development, its role in therapeutic resistance remains unknown. In this study, we
Externí odkaz:
https://doaj.org/article/d33a6b81cd094ae1a1474337a9def750
Autor:
Zhuo-Xian Rong, Zhi Li, Jun-Ju He, Li-Yu Liu, Xin-Xin Ren, Jie Gao, Yun Mu, Yi-Di Guan, Yu-Mei Duan, Xiu-Ping Zhang, De-Xiang Zhang, Nan Li, Yue-Zhen Deng, Lun-Quan Sun
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Intrahepatic cholangiocarcinoma (ICC) ranks as the second most malignant type of primary liver cancer with a high degree of incidence and a very poor prognosis. Fat mass and obesity-associated protein (FTO) functions as an eraser of the RNA m6A modif
Externí odkaz:
https://doaj.org/article/cd641552f779412d9d3733c26ddeaef1
Autor:
Mei Wen, Zhen-ke Deng, Shi-long Jiang, Yi-di Guan, Hai-zhou Wu, Xin-luan Wang, Song-shu Xiao, Yi Zhang, Jin-ming Yang, Dong-sheng Cao, Yan Cheng
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Bcl-2 family protein is an important factor in regulating apoptosis and is associated with cancer. The anti-apoptotic proteins of Bcl-2 family, such as Bcl-2, are overexpression in numerous tumors, and contribute to cancer formation, development, and
Externí odkaz:
https://doaj.org/article/caf8e622526f42f8a8545e011a67fb92
Autor:
Yi-Jie Ren, Xiao-Hui Wang, Cheng Ji, Yi-Di Guan, Xian-Jiu Lu, Xian-Rong Liu, Hong-Han Zhang, Ling-Chuan Guo, Qiong-Hua Xu, Wei-Dong Zhu, Zhi-Jun Ming, Jin-Ming Yang, Yan Cheng, Yi Zhang
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
In order to survive under conditions of low oxygen, cancer cells can undergo a metabolic switch to glycolysis and suppress mitochondrial respiration in order to reduce oxygen consumption and prevent excessive amounts of reactive oxygen species (ROS)
Externí odkaz:
https://doaj.org/article/cfb333240e8a4ed091ae4aa0b6890348
Autor:
Xingcong Ren, Yan Cheng, Wen-Ling Ye, Yongguang Tao, Shi-long Jiang, Mingzhu Yin, Yi-Di Guan, Dong-Sheng Cao, Jin-Ming Yang, Xin-luan Wang, Kuansong Wang, Yi Zhang
Publikováno v:
Cell Death and Disease, Vol 11, Iss 11, Pp 1-15 (2020)
Cell Death & Disease
Cell Death & Disease
Oncogenic activation of the mTOR signaling pathway occurs frequently in tumor cells and contributes to the devastating features of cancer, including breast cancer. mTOR inhibitors rapalogs are promising anticancer agents in clinical trials; however,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ac368f83e5b9942276872602b1243f
http://link.springer.com/article/10.1038/s41419-020-03153-x
http://link.springer.com/article/10.1038/s41419-020-03153-x
Autor:
Dong-Sheng Cao, Xi-Sha Chen, Kuansong Wang, Jin-Ming Yang, Yi-Di Guan, Lan-ya Li, Xin-luan Wang, Yongguang Tao, Yi Zhang, Minghua Wu, Mingzhu Yin, Xin-Yuan Sun, Xingcong Ren, Yan Cheng, Ao-Xue Li
Publikováno v:
Oncogene. 39:6704-6718
Autophagy can protect stressed cancer cell by degradation of damaged proteins and organelles. However, the regulatory mechanisms behind this cellular process remain incompletely understood. Here, we demonstrate that RSK2 (p90 ribosomal S6 kinase 2) p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b663896f0dd0160190d0876c9b5998e
https://doi.org/10.1038/s41388-020-01447-0
https://doi.org/10.1038/s41388-020-01447-0
Autor:
Weiwei Xue, Qian Cao, Liu-Xia Zhang, Yi-Di Guan, Dong-Sheng Cao, Yan Cheng, Alex F. Chen, Wen-Ling Ye
Publikováno v:
New Journal of Chemistry. 43:19097-19106
Eukaryotic elongation factor-2 kinase (eEF2K), a calcium/calmodulin-dependent protein kinase, is a potential target for treating cancer. eEF2K can reduce the binding ability of eEF2 to ribosomes by phosphorylating eEF2, thereby inhibiting peptide cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89ef32d0110e870d327cbecd274025e9
https://doi.org/10.1039/c9nj02600b
https://doi.org/10.1039/c9nj02600b
Autor:
Zhuo-Xian Rong, Jie Gao, Xinxin Ren, Yingjie Nie, Yu-Yuan Zi, Zhi Li, Zilong Qiu, Nan Li, Lun-Quan Sun, Qi Fan, Yuezhen Deng, Yun Mu, Xiaoyu Liu, Yuefang Zhang, Zhen Cao, Zimei Zeng, Xitao Wang, Qian Pei, Xiang Wang, Xu Xu, Haiguang Xin, Yi-Di Guan
Publikováno v:
Cancer research. 82(1)
Metabolic reprogramming by oncogenic signaling is a hallmark of cancer. Hyperactivation of Wnt/β-catenin signaling has been reported in hepatocellular carcinoma (HCC). However, the mechanisms inducing hyperactivation of Wnt/β-catenin signaling and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dbf405ee95401c18bce85187755da47
https://pubmed.ncbi.nlm.nih.gov/34764205
https://pubmed.ncbi.nlm.nih.gov/34764205
Autor:
Shi-long Jiang, Yi-Di Guan, Jin-Ming Yang, Yi Zhang, Dong-Sheng Cao, Yan Cheng, Liu-Xia Zhang, Xi-Sha Chen, Alex F. Chen
Publikováno v:
European journal of medicinal chemistry. 199
It has been realized that FDA approved drugs may have more molecular targets than is commonly thought. Thus, to find the exact drug-target interactions (DTIs) is of great significance for exploring the new molecular mechanism of drugs. Here, we devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::147c2b982e93b81e68bac677851e1897
https://pubmed.ncbi.nlm.nih.gov/32428794
https://pubmed.ncbi.nlm.nih.gov/32428794