Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Yi Ting (Kayla) Lien"'
Autor:
Michelle A. Pressly, Lambertus A. Peletier, Songmao Zheng, Vishnu D. Sharma, Yi Ting (Kayla) Lien, Weirong Wang, Honghui Zhou, Stephan Schmidt
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 5, Pp 639-655 (2023)
Abstract The main objective of this tutorial is to provide the readers with a roadmap of how to establish increasingly complex target‐mediated drug disposition (TMDD) models for monoclonal antibodies. To this end, we built mathematical models, each
Externí odkaz:
https://doaj.org/article/26f7499bfef749dda8f7599767d5d989
Autor:
Logan Brooks, Michael Dolton, Jurgen Langenhorst, Kenta Yoshida, Yi Ting (Kayla) Lien, Vikram Malhi, Chunze Li, Pablo Perez‐Moreno, John Bond, Ya‐Chi Chen, Jiajie Yu
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 5, Pp 823-834 (2023)
Abstract Concentration‐QTc (C‐QTc) analysis has become a common approach for evaluating proarrhythmic risk and delayed cardiac repolarization of oncology drug candidates. Significant heart rate (HR) change has been associated with certain classes
Externí odkaz:
https://doaj.org/article/309c621807754593873a9d5a3f1647b8
Autor:
Edwin Lam, Yi Ting (Kayla) Lien, Walter K. Kraft, Douglas F. Stickle, Beth Piraino, Jingjing Zhang
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 3, Pp 649-657 (2022)
Abstract It is unclear if the pharmacokinetics of vancomycin are the same during automated peritoneal dialysis (APD), where cycler exchanges may affect the systemic, peritoneal, and urinary disposition of drug. We conducted a prospective pharmacokine
Externí odkaz:
https://doaj.org/article/da8f6d9254c1484c9228620e5ce7354c
Autor:
Sumit Basu, Yi Ting (Kayla) Lien, Valvanera Vozmediano, Jan-Frederik Schlender, Thomas Eissing, Stephan Schmidt, Christoph Niederalt
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Physiologically based pharmacokinetic (PBPK) models are increasingly used to support pediatric dose selection for small molecule drugs. In contrast, only a few pediatric PBPK models for therapeutic antibodies have been published recently, and the kno
Externí odkaz:
https://doaj.org/article/288902e7c998413bb6490a1f965d1cd0
Autor:
Logan Brooks, Michael Dolton, Jurgen Langenhorst, Kenta Yoshida, Yi Ting (Kayla) Lien, Vikram Malhi, Chunze Li, Pablo Perez‐Moreno, John Bond, Ya‐Chi Chen, Jiajie Yu
Publikováno v:
Clinical and Translational Science. 16:823-834
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf0bbae325e7600ec44001d805e5a55f
https://doi.org/10.1111/cts.13491
https://doi.org/10.1111/cts.13491
Autor:
Beth Piraino, Douglas F. Stickle, Jingjing Zhang, Yi Ting Kayla Lien, Walter K. Kraft, Edwin Lam
Publikováno v:
Clinical and Translational Science. 15:649-657
It is unclear if the pharmacokinetics of vancomycin are the same during automated peritoneal dialysis (APD), where cycler exchanges may affect the systemic, peritoneal, and urinary disposition of drug. We conducted a prospective pharmacokinetic study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae45ffed832de299b655dfd453f84039
https://doi.org/10.1111/cts.13182
https://doi.org/10.1111/cts.13182
Autor:
Vincent Lemaire, David Bassen, Mike Reed, Roy Song, Samira Khalili, Yi Ting (Kayla) Lien, Lu Huang, Aman P. Singh, Spyros Stamatelos, Dean Bottino, Fei Hua
Publikováno v:
Clinical pharmacology and therapeutics.
Immuno-oncology (IO) is a fast-expanding field due to recent success using IO therapies in treating cancer. As IO therapies do not directly kill tumor cells but rather act upon the patients' own immune cells either systemically or in the tumor microe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87d59b80f4f7a3ef9984a1bdd14d08ad
https://pubmed.ncbi.nlm.nih.gov/36282521
https://pubmed.ncbi.nlm.nih.gov/36282521
Autor:
Valvanera Vozmediano, Beth Piraino, Jingjing Zhang, Yi Ting Kayla Lien, Walter K. Kraft, Edwin Lam, Stephan Schmidt
Publikováno v:
Perit Dial Int
Intraperitoneal vancomycin is the first-line therapy in the management of peritoneal dialysis (PD)-related peritonitis. However, due to the paucity of data, vancomycin dosing for peritonitis in patients on automated peritoneal dialysis (APD) is empir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1869996c819d9002f70d25cbc06976b
https://doi.org/10.1177/0896860819889774
https://doi.org/10.1177/0896860819889774
Autor:
Snehal Samant, Kumpal Madrasi, Yi Ting Kayla Lien, Myong-Jin Kim, Stephan Schmidt, Li Li, Yaning Wang, Fang Li
Publikováno v:
The Journal of Clinical Pharmacology. 60
Costly and lengthy clinical trials hinder the development of safe and effective treatments for postmenopausal osteoporosis. To reduce the expense associated with these trials, we established a mechanistic disease-drug trial model for postmenopausal o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dca8e3b9c05dc9483e671ec736f7a60
https://doi.org/10.1002/jcph.1748
https://doi.org/10.1002/jcph.1748
Publikováno v:
Quantitative Pharmacology and Individualized Therapy Strategies in Development of Therapeutic Proteins for Immune-Mediated Inflammatory Diseases ISBN: 9781119289234
Quantitative Pharmacology and Individualized Therapy Strategies in Development of Therapeutic Proteins for Immune-Mediated Inflammatory Diseases
Quantitative Pharmacology and Individualized Therapy Strategies in Development of Therapeutic Proteins for Immune-Mediated Inflammatory Diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f81fa57e13e833fccd6a75785d0c07bd
https://doi.org/10.1002/9781119289234.ch10
https://doi.org/10.1002/9781119289234.ch10
