Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Yi Na, Dong"'
Autor:
Yi Na Dong, Lucie Vanessa Ngaba, Jacob An, Miniat W. Adeshina, Nathan Warren, Johnathan Wong, David R. Lynch
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Friedreich’s ataxia (FRDA), the most common recessive inherited ataxia, results from homozygous guanine–adenine–adenine (GAA) repeat expansions in intron 1 of the FXN gene, which leads to the deficiency of frataxin, a mitochondrial protein esse
Externí odkaz:
https://doaj.org/article/85c6507586d1444db36870ac27abd122
Autor:
Yi Na Dong, Elizabeth Mercado-Ayón, Jennifer Coulman, Liam Flatley, Lucie Vanessa Ngaba, Miniat W. Adeshina, David R. Lynch
Publikováno v:
Cells, Vol 13, Iss 12, p 1040 (2024)
Friedreich’s ataxia (FRDA) is a progressive neurodegenerative disease caused in almost all patients by expanded guanine–adenine–adenine (GAA) trinucleotide repeats within intron 1 of the FXN gene. This results in a relative deficiency of fratax
Externí odkaz:
https://doaj.org/article/2f8e9649ac8d4dfbb434b16ce0507ad7
Autor:
Layne N. Rodden, Christian Rummey, Yi Na Dong, Sarah Lagedrost, Sean Regner, Alicia Brocht, Khalaf Bushara, Martin B. Delatycki, Christopher M. Gomez, Katherine Mathews, Sarah Murray, Susan Perlman, Bernard Ravina, S. H. Subramony, George Wilmot, Theresa Zesiewicz, Alessandra Bolotta, Alain Domissy, Christine Jespersen, Baohu Ji, Elisabetta Soragni, Joel M. Gottesfeld, David R. Lynch
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Introduction: Friedreich ataxia (FRDA) is a recessive neurodegenerative disease characterized by progressive ataxia, dyscoordination, and loss of vision. The variable length of the pathogenic GAA triplet repeat expansion in the FXN gene in part expla
Externí odkaz:
https://doaj.org/article/fc3b8365f48643339b44ac26a1d1ebf4
Autor:
Yi Na Dong, Fu-Chun Hsu, Cynthia J. Koziol-White, Victoria Stepanova, Joseph Jude, Andrei Gritsiuta, Ryan Rue, Rosalind Mott, Douglas A. Coulter, Reynold A. Panettieri, Vera P. Krymskaya, Hajime Takano, Elena A. Goncharova, Dmitry A. Goncharov, Douglas B. Cines, David R. Lynch
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract N-methyl-d-aspartate (NMDA) receptors are widely expressed in the central nervous system. However, their presence and function at extraneuronal sites is less well characterized. In the present study, we examined the expression of NMDA recept
Externí odkaz:
https://doaj.org/article/8bd4b029a3e741f88fc9ecbfcf332be3
Autor:
Elizabeth Mercado-Ayón, Nathan Warren, Sarah Halawani, Layne N. Rodden, Lucie Ngaba, Yi Na Dong, Joshua C. Chang, Carlos Fonck, Fulvio Mavilio, David R. Lynch, Hong Lin
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disorder caused by deficiency of the mitochondrial protein frataxin. Lack of frataxin causes neuronal loss in various areas of the CNS and PNS. In particular, cerebellar neuropathol
Externí odkaz:
https://doaj.org/article/937f332ab4914f01a406fb9a4d915a61
Autor:
Laura Rodríguez-Pascau, Elena Britti, Pablo Calap-Quintana, Yi Na Dong, Cristina Vergara, Fabien Delaspre, Marta Medina-Carbonero, Jordi Tamarit, Federico V. Pallardó, Pilar Gonzalez-Cabo, Joaquim Ros, David R. Lynch, Marc Martinell, Pilar Pizcueta
Publikováno v:
Neurobiology of Disease, Vol 148, Iss , Pp 105162- (2021)
Friedreich ataxia (FRDA), the most common autosomal recessive ataxia, is characterized by degeneration of the large sensory neurons and spinocerebellar tracts, cardiomyopathy, and increased incidence in diabetes. The underlying pathophysiological mec
Externí odkaz:
https://doaj.org/article/d8901ebb28414e638a9b30b6d425544b
Autor:
Hong Lin, Jordi Magrane, Amy Rattelle, Anna Stepanova, Alexander Galkin, Elisia M. Clark, Yi Na Dong, Sarah M. Halawani, David R. Lynch
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 11, Pp 1343-1352 (2017)
Friedreich ataxia (FRDA), the most common recessive inherited ataxia, results from deficiency of frataxin, a small mitochondrial protein crucial for iron-sulphur cluster formation and ATP production. Frataxin deficiency is associated with mitochondri
Externí odkaz:
https://doaj.org/article/d79fcb553b9b47c5bc781c43cb423749
Autor:
David P. Scanlon, Alaji Bah, Mickaël Krzeminski, Wenbo Zhang, Heather L. Leduc-Pessah, Yi Na Dong, Julie D. Forman-Kay, Michael W. Salter
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
N-methyl D-aspartate receptor (NMDAR) activity is modulated by Src tyrosine kinase via the mitochondrial protein NADH dehydrogenase subunit 2 (ND2). Here the authors show that ND2 interacts with the transmembrane region of NMDAR GluN1 subunit, a proc
Externí odkaz:
https://doaj.org/article/50c00c45052a4a68a4e123d4c54090df
Autor:
Hong Lin, Jordi Magrane, Amy Rattelle, Anna Stepanova, Alexander Galkin, Elisia M. Clark, Yi Na Dong, Sarah M. Halawani, David R. Lynch
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 1 (2018)
Externí odkaz:
https://doaj.org/article/97cbd0599aa94169adb7d5b8df7ca5e5
Publikováno v:
European Journal of Inorganic Chemistry. 2021:2063-2069