Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Yi Long Huang"'
Autor:
Mailis Liiv, Annika Vaarmann, Dzhamilja Safiulina, Vinay Choubey, Ruby Gupta, Malle Kuum, Lucia Janickova, Zuzana Hodurova, Michal Cagalinec, Akbar Zeb, Miriam A. Hickey, Yi-Long Huang, Nana Gogichaishvili, Merle Mandel, Mario Plaas, Eero Vasar, Jens Loncke, Tim Vervliet, Ting-Fen Tsai, Geert Bultynck, Vladimir Veksler, Allen Kaasik
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Wolfram syndrome is a rare genetic disease caused by mutations in the WFS1 or CISD2 gene. A primary defect in Wolfram syndrome involves poor ER Ca2+ handling, but how this disturbance leads to the disease is not known. The current study, per
Externí odkaz:
https://doaj.org/article/7119060b6c6844ed9cd995417943a2ed
Publikováno v:
BMC Musculoskeletal Disorders, Vol 25, Iss 1, Pp 1-11 (2024)
Abstract Background Extracellular matrix (ECM) remodeling in skeletal muscle is a significant factor in the development of sarcopenia. This study aims to evaluate changes in ECM remodeling in the lumbar paravertebral muscles of sarcopenic rats using
Externí odkaz:
https://doaj.org/article/ea718837d89a4f94a98cd027399175b2
Autor:
Xin-Chen Huang, Yi-Long Huang, Yi-Tong Guo, Si-Yu Li, Chao Gao, Jia-Xin Chen, Ji-Yao Ma, Bo He
Publikováno v:
Experimental Gerontology, Vol 183, Iss , Pp 112322- (2023)
Background: Severe sarcopenia may result in severe disability. Early diagnosis is currently the key to enhancing the treatment of sarcopenia, and there is an urgent need for a highly sensitive and dependable tool to evaluate the course of early sarco
Externí odkaz:
https://doaj.org/article/e4f48bc1105d495fb8bcf946922fc6cc
Autor:
Wei-Ju Lin, Wei-Ju Lee, Li-Ning Peng, Yi-Long Huang, Chien-Yi Tung, Chi-Hung Lin, Ting-Fen Tsai, Liang-Kung Chen
Publikováno v:
Experimental Gerontology, Vol 172, Iss , Pp 112053- (2023)
Tumor necrosis factor (TNF)-α is a proinflammatory cytokine involved in the pathogenesis of sarcopenia, but its short half-life and inconsistent reproducibility limit the potential of TNF-α to be an ideal sarcopenia biomarker. Anti-TNF-α, a natura
Externí odkaz:
https://doaj.org/article/2a9e3e03109147ba8a8d80655a53bc6d
Autor:
Zhao-Qing Shen, Yi-Fan Chen, Jim-Ray Chen, Yuh-Shan Jou, Pei-Chun Wu, Cheng-Heng Kao, Chih-Hao Wang, Yi-Long Huang, Chian-Feng Chen, Ting-Shuo Huang, Yu-Chiau Shyu, Shih-Feng Tsai, Lung-Sen Kao, Ting-Fen Tsai
Publikováno v:
Cell Reports, Vol 21, Iss 8, Pp 2198-2211 (2017)
CISD2 is located within the chromosome 4q region frequently deleted in hepatocellular carcinoma (HCC). Mice with Cisd2 heterozygous deficiency develop a phenotype similar to the clinical manifestation of nonalcoholic fatty liver disease (NAFLD) and n
Externí odkaz:
https://doaj.org/article/d9514aa1af2d4cba9ff02d52ab7e23ad
Autor:
Yi-Long Huang, Chao-Hsiung Lin, Tsung-Hsien Tsai, Chen-Hua Huang, Jie-Ling Li, Liang-Kung Chen, Chun-Hsien Li, Ting-Fen Tsai, Pei-Ning Wang
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 20, p 10903 (2021)
Assessing dementia conversion in patients with mild cognitive impairment (MCI) remains challenging owing to pathological heterogeneity. While many MCI patients ultimately proceed to Alzheimer’s disease (AD), a subset of patients remain stable for v
Externí odkaz:
https://doaj.org/article/ac4f26d113b947c7a73a505c525bfbad
Publikováno v:
Biomedicines, Vol 9, Iss 9, p 1229 (2021)
Cisd2 (CDGSH iron sulfur domain 2) is a pro-longevity gene that extends the lifespan and health span of mice, ameliorates age-associated structural damage and limits functional decline in multiple tissues. Non-alcoholic fatty liver disease (NAFLD), w
Externí odkaz:
https://doaj.org/article/82d0f68f104146a4b0c25a890ae522ac
Publikováno v:
The Journals of Gerontology: Series A.
The aging process is complicated and involves diverse organ dysfunction; furthermore, the biomarkers that are able to reflect biological aging are eagerly sought after to monitor the system-wide decline associated with the aging process. To address t
Publikováno v:
Antioxidants, Vol 10, Iss 4, p 559 (2021)
Nonalcoholic fatty liver disease (NAFLD) and its more severe form, nonalcoholic steatohepatitis (NASH), are the most common chronic liver diseases worldwide. However, drugs to treat NAFLD and NASH are an unmet clinical need. This study sought to prov
Externí odkaz:
https://doaj.org/article/46a95051757e462fb0dc65d327e434d5
Publikováno v:
2022 IEEE 7th Southern Power Electronics Conference (SPEC).