Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Yi Lisa Lyu"'
Autor:
Ying Li, Hailing Hao, Evangeline Tzatzalos, Ren-Kuo Lin, Sungtae Doh, Leroy F. Liu, Yi Lisa Lyu, Li Cai
Publikováno v:
Biology Open, Vol 3, Iss 2, Pp 172-184 (2014)
Summary Topoisomerase IIbeta (Top2b) is an enzyme that modulates DNA supercoiling by catalyzing the passage of DNA duplexes through one another. It is ubiquitously expressed in postmitotic cells and known to function during the development of neuromu
Externí odkaz:
https://doaj.org/article/9b51beacd1ad4e30992d83114e21c98c
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106966 (2014)
NF-κB plays an important role in cancer initiation and progression. CD44, a cell surface glycoprotein, is involved in many cellular processes including cell adhesion, migration and proliferation. However, whether and how the two molecules interact i
Externí odkaz:
https://doaj.org/article/329442acde99426c9bb508bc8baa64a3
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32542 (2012)
Low doses of anticancer drugs have been shown to enhance antitumor immune response and increase the efficacy of immunotherapy. The molecular basis for such effects remains elusive, although selective depletion of T regulatory cells has been demonstra
Externí odkaz:
https://doaj.org/article/4d3adabd17e144ed8665bc735940c869
Autor:
Yu-Chen Tsai, Sidney Pestka, Lu-Hai Wang, Loren W Runnels, Shan Wan, Yi Lisa Lyu, Leroy F Liu
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e24291 (2011)
Increasing evidence has pointed to activated type I interferon signaling in tumors. However, the molecular basis for such activation and its role in tumorigenesis remain unclear. In the current studies, we report that activation of type I interferon
Externí odkaz:
https://doaj.org/article/1efcd8a059f4494ea067b770a467024e
Publikováno v:
PLoS ONE, Vol 3, Iss 4, p e2009 (2008)
DNA damage such as double-stranded DNA breaks (DSBs) has been reported to stimulate mitochondrial biogenesis. However, the underlying mechanism is poorly understood. The major player in response to DSBs is ATM (ataxia telangiectasia mutated). Upon se
Externí odkaz:
https://doaj.org/article/3c5e9c4a0e2e463485471a063d76eae0
Autor:
Misaal Patel, Brianna Rodriguez, Yi Lisa Lyu, Ying Li, Ki-Bum Lee, Sofia Castro-Pedrido, Shunyao Lei, Jeremy Anderson, Zachary Finkel, Ryan Skinner, Li Cai, Fatima Esteban
Publikováno v:
Molecular Therapy. 29:2469-2482
Promoting residential cells, particularly endogenous neural stem and progenitor cells (NSPCs), for tissue regeneration represents a potential strategy for the treatment of spinal cord injury (SCI). However, adult NSPCs differentiate mainly into glial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d170949377a54ea88318a7a2ec45a575
https://doi.org/10.1016/j.ymthe.2021.04.027
https://doi.org/10.1016/j.ymthe.2021.04.027
Autor:
Brianna Rodriguez, Misaal Patel, Ying Li, Zachary Finkel, Fatima Esteban, Rebecca Risman, Jeremy Anderson, Shunyao Lei, Li Cai, Ki-Bum Lee, Yi Lisa Lyu
Publikováno v:
Exp Neurol
Nkx6.1 plays an essential role during the embryonic development of the spinal cord. However, its role in the adult and injured spinal cord is not well understood. Here we show that lentivirus-mediated Nkx6.1 expression in the adult injured mouse spin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9c07ac4568e8b92b37ff94da534dd6
https://europepmc.org/articles/PMC9050175/
https://europepmc.org/articles/PMC9050175/
Autor:
Ki-Bum Lee, Mavis R. Swerdel, Yi Lisa Lyu, Ronald P. Hart, Hyeon-Yeol Cho, Hailing Hao, Ying Li, Li Cai
Publikováno v:
Journal of Neuroscience Research. 95:1951-1964
Topoisomerase II beta (Top2b) is an enzyme that alters the topologic states of DNA during transcription. Top2b deletion in early retinal progenitor cells causes severe defects in neural differentiation and affects cell survival in all retinal cell ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4459975829e53fe1112939dc03f8302b
https://doi.org/10.1002/jnr.24037
https://doi.org/10.1002/jnr.24037
Autor:
Yongzheng Zhang, Melvin P. Weinstein, Stephanie Saravolatz, Edmond J. LaVoie, Yi Lisa Lyu, Ajit K. Parhi, Joan Pawlak, Daniel S. Pilch, Louis D. Saravolatz, Malvika Kaul, Lilly Mark
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:4845-4855
The clinical development of FtsZ-targeting benzamide compounds like PC190723 has been limited by poor drug-like and pharmacokinetic properties. Development of prodrugs of PC190723 (e.g., TXY541) resulted in enhanced pharmaceutical properties, which,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfecd04c0f39ec97da7f2259708bcb89
https://doi.org/10.1128/aac.00708-15
https://doi.org/10.1128/aac.00708-15
Publikováno v:
Journal of Biological Chemistry. 288:7182-7192
Camptothecin (CPT), a topoisomerase (Top) I-targeting drug that stabilizes Top1-DNA covalent adducts, can induce S-phase-specific cytotoxicity due to the arrest of progressing replication forks. However, CPT-induced non-S-phase cytotoxicity is less w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8305f8dffc17af1ec99a66576e76626
https://doi.org/10.1074/jbc.m112.415471
https://doi.org/10.1074/jbc.m112.415471