Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Yi Liang Liu"'
Suppression of the human malic enzyme 2 modifies energy metabolism and inhibits cellular respiration
Autor:
Ju-Yi Hsieh, Kun-Chi Chen, Chun-Hsiung Wang, Guang-Yaw Liu, Jie-An Ye, Yu-Tung Chou, Yi-Chun Lin, Cheng-Jhe Lyu, Rui-Ying Chang, Yi-Liang Liu, Yen-Hsien Li, Mau-Rong Lee, Meng-Chiao Ho, Hui-Chih Hung
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-18 (2023)
Abstract Human mitochondrial NAD(P)+-dependent malic enzyme (ME2) is well-known for its role in cell metabolism, which may be involved in cancer or epilepsy. We present potent ME2 inhibitors based on cyro-EM structures that target ME2 enzyme activity
Externí odkaz:
https://doaj.org/article/8c54706653c84fc5ab3e4d4963ea7c0e
Autor:
Yi-Fang Yang, Chuang-Ming Wang, I.-Hsin Hsiao, Yi-Liang Liu, Wen-Hao Lin, Chih-Li Lin, Hui-Chih Hung, Guang-Yaw Liu
Publikováno v:
Cellular & Molecular Biology Letters, Vol 27, Iss 1, Pp 1-25 (2022)
Abstract Peptididylarginine deiminase type 2 (PADI2) catalyzes the conversion of arginine residues to citrulline residues on proteins. We demonstrate that PADI2 induces T cell activation and investigate how PADI2 promotes activated T cell autonomous
Externí odkaz:
https://doaj.org/article/802dbea7a5d24e36b93b82939b615eb4
Autor:
Kristyn Hayashi, Kenton L. Longenecker, Yi-Liang Liu, Bryan Faust, Aditi Prashar, Johannes Hampl, Vincent Stoll, Sandro Vivona
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Melanotransferrin (MTf) is an iron-binding member of the transferrin superfamily that can be membrane-anchored or secreted in serum. On cells, it can mediate transferrin-independent iron uptake and promote proliferation. In serum, it is a tr
Externí odkaz:
https://doaj.org/article/e40faf28a7d64f9d868ff1e3a76c9fde
Publikováno v:
Symmetry, Vol 14, Iss 10, p 2102 (2022)
In this paper, we investigate a spherically symmetric inverse heat conduction problem, which determines the internal surface temperature distribution of the hollow sphere from measured data at the fixed location inside it. This problem is ill-posed,
Externí odkaz:
https://doaj.org/article/52644d8b68854108b1483ddee83fb9a6
Autor:
Ju-Yi Hsieh, Hao-Ping Yang, Sunil Kumar Tewary, Hui-Chen Cheng, Yi-Liang Liu, Shih-Chieh Tai, Wei-Lin Chen, Chien-Hui Hsu, Ting-Jhen Huang, Chuan-Jung Chou, Yu-Nan Huang, Ching-Tien Peng, Meng-Chiao Ho, Guang-Yaw Liu, Hui-Chih Hung
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102034- (2021)
Summary: Human mitochondrial NAD(P)+-dependent malic enzyme (ME2) is well recognized to associate with cancer cell metabolism, and the single nucleotide variants (SNVs) of ME2 may play a role in enzyme regulation. Here we reported that the SNVs of ME
Externí odkaz:
https://doaj.org/article/4346595fc4e4492a8c26e89d16339be5
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Our recent studies of peptidylarginine deiminase 4 (PAD4) demonstrate that its non-catalytic Ca2+-binding sites play a crucial role in the assembly of the correct geometry of the enzyme. Here, we examined the folding mechanism of PAD4 and th
Externí odkaz:
https://doaj.org/article/9aceff9d3ef9404389090cd44055a0a0
Autor:
Yi‐Liang Liu, I‐Hsin Hsiao, Yen‐Hung Lin, Chih‐Li Lin, Ming‐Shiou Jan, Hui‐Chih Hung, Guang‐Yaw Liu
Publikováno v:
Journal of Cellular Physiology. 237:2140-2154
We present a mechanism for how ornithine decarboxylase (ODC) regulates the crosstalk between autophagy and apoptosis. In cancer cells, low-intensity ultraviolet B (UVB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6e58bd224c8cbbe71e9f790912064a3
https://doi.org/10.1002/jcp.30678
https://doi.org/10.1002/jcp.30678
Publikováno v:
Open Mathematics. 20:1030-1038
In this article, we consider a two-dimensional inverse heat conduction problem that determines the surface temperature distribution from measured data at the fixed location. This problem is severely ill-posed, i.e., the solution does not depend conti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c5a2633b4d2b78f0c653966875d396d
https://doi.org/10.1515/math-2022-0489
https://doi.org/10.1515/math-2022-0489
Publikováno v:
Tongxin xuebao, Vol 35, Pp 233-239 (2014)
Vehicle networking intrusion detection solutions (IDS) can be used to confirm the authenticity of the events described in the notice of traffic incidents.The current Vehicle networking IDS frequently use detection scheme based on the consistency of r
Externí odkaz:
https://doaj.org/article/b9a6e905492343f0867ba4c3eb9fe234
Autor:
Chien-Yun Lee, Hui-Chih Hung, Chi-Li Lin, Ju-Yi Hsieh, Yi-Liang Liu, Guang-Yaw Liu, Yi-Fang Yang
Publikováno v:
Journal of Cellular Physiology. 236:5646-5663
This study reveals an uncovered mechanism for the regulation of polyamine homeostasis through protein arginyl citrullination of antizyme (AZ), a natural inhibitor of ornithine decarboxylase (ODC). ODC is critical for the cellular production of polyam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f39d58758fb78d9a0ef06f4107825139
https://doi.org/10.1002/jcp.30252
https://doi.org/10.1002/jcp.30252