Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Yi Jia Li"'
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/b642eaa87a784b0cb2f3faa5e03b062b
Autor:
Qianqian Zhao, Adrian Kohut, Yi-Jia Li, Antons Martincuks, Theresa Austria, Chunyan Zhang, Nicole Lugo Santiago, Rosemarie Martinez Borrero, Xuan Thuy Phan, Laleh Melstrom, Lorna Rodriguez-Rodriguez, Hua Yu
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Recently, poly(ADP-ribosyl)ation polymerase inhibitors (PARPis), which induce synthetic lethality of tumor cells with DNA damage repair defects, have emerged as a promising therapy for ovarian, breast, and pancreatic cancer. Although the PARPi Olapar
Externí odkaz:
https://doaj.org/article/39c14fa5669444e889ed0d1e0d5c327b
Autor:
Antons Martincuks, Jieun Song, Adrian Kohut, Chunyan Zhang, Yi-Jia Li, Qianqian Zhao, Edward Mak, Lorna Rodriguez-Rodriguez, Hua Yu, Mihaela Cristea
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Despite the promising activity of poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi) in many cancer types with defects in the DNA damage response the majority of the treated patients acquire PARPi resistance and succumb to their diseases. Conseque
Externí odkaz:
https://doaj.org/article/5021de688e324a6394b97709ac61908c
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Clinically, immune cell function is correlated with pathogenesis of endometrial polyp (EP) and infertility of women of reproductive-age. However, the underlying immune cell hallmark in EP patients remains unclear. Here, we focused on analyzing circul
Externí odkaz:
https://doaj.org/article/54f5d8ff3c0e437a8c00b6bc6b0e50ce
Autor:
Maryam Aftabizadeh, Yi-Jia Li, Qianqian Zhao, Chunyan Zhang, Nigus Ambaye, Jieun Song, Toshikage Nagao, Christoph Lahtz, Marwan Fakih, David K. Ann, Hua Yu, Andreas Herrmann
Publikováno v:
JCI Insight, Vol 6, Iss 2 (2021)
To date, there are no inhibitors that directly and specifically target activated STAT3 and c-Myc in the clinic. Although peptide-based inhibitors can selectively block activated targets, their clinical usage is limited because of low cell penetration
Externí odkaz:
https://doaj.org/article/a70c3245362f49b19530eb16ddef47e5
Autor:
Antons Martincuks, Pei-Chuan Li, Qianqian Zhao, Chunyan Zhang, Yi-Jia Li, Hua Yu, Lorna Rodriguez-Rodriguez
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Despite significant progress in cancer therapy over the last decades, ovarian cancer remains the most lethal gynecologic malignancy worldwide with the five-year overall survival rate less than 30% due to frequent disease recurrence and chemoresistanc
Externí odkaz:
https://doaj.org/article/96062329de784f1daec48555a07d0af9
Autor:
Li Du, Yi-Jia Li, Marwan Fakih, Rebecca L. Wiatrek, Marjun Duldulao, Zhenbin Chen, Peiguo Chu, Julio Garcia-Aguilar, Yuan Chen
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Cancer stem cells (CSCs) have key roles in tumor initiation and metastasis. Here, the authors show that the SUMO E1 and global sumoylation levels are high in colorectal CSCs and that depletion of the catalytic subunit of the SUMO E1, SAE2, affects CS
Externí odkaz:
https://doaj.org/article/06fb9b69954d417596dc90173bdd25cb
Autor:
Aileen Y. Alontaga, Nigus D. Ambaye, Yi-Jia Li, Ramir Vega, Chih-Hong Chen, Krzysztof P. Bzymek, John C. Williams, Weidong Hu, Yuan Chen
Publikováno v:
Data in Brief, Vol 7, Iss , Pp 195-200 (2016)
Post-translational modifications by the small ubiquitin-like modifiers (SUMO), in particular the formation of poly-SUMO-2 and -3 chains, regulates essential cellular functions and its aberration leads to life-threatening diseases (Geoffroy and Hay, 2
Externí odkaz:
https://doaj.org/article/5548b7938942486ba2075df52e0d7a60
Autor:
Fu-Ping Guo, Yi-Jia Li, Zhi-Feng Qiu, Wei Lv, Yang Han, Jing Xie, Yan-Ling Li, Xiao-Jing Song, Shan-Shan Du, Vikram Mehraj, Tai-Sheng Li, Jean-Pierre Routy
Publikováno v:
Chinese Medical Journal, Vol 129, Iss 22, Pp 2683-2690 (2016)
Background: Among HIV-infected patients initiating antiretroviral therapy (ART), early changes in CD4+ T-cell subsets are well described. However, HIV-infected late presenters initiating treatment present with a suboptimal CD4+ T-cell reconstitution
Externí odkaz:
https://doaj.org/article/76bdf7b828bb47faba376a25cb4f7f0d
Autor:
Xiao-Shuang Cai, Zhao Qin, Xue-De Wang, Yi-Jia Li, Hua-Min Liu, Shi-Yuan Ma, Ji-Hui Jiang, Wen-Bo Miao
Publikováno v:
International Journal of Food Science & Technology. 57:662-675