Zobrazeno 1 - 10
of 299
pro vyhledávání: '"Yi Cheng, Chang"'
Autor:
Hsin-Hsien Lin, I-Shing Yu, Ming-Shan Cheng, Tien-Jyun Chang, Hsin-Ying Lin, Yi-Cheng Chang, Chun-Jung Ko, Ping-Hung Chen, Shu-Wha Lin, Tai-Chung Huang, Shin-Yi Huang, Tzu-Yu Chen, Kai-Wen Kan, Hsiang-Po Huang, Ming-Shyue Lee
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract SPINT1, a membrane-anchored serine protease inhibitor, regulates cascades of pericellular proteolysis while its tissue-specific functions remain incompletely characterized. In this study, we generate Spint1-lacZ knock-in mice and observe Spi
Externí odkaz:
https://doaj.org/article/3506b4099ee349eebd14208db3231299
Autor:
Chia-Ju Liu, Jien-jiun Chen, Jo-Hsuan Wu, Yao-Te Chung, Jin-Wun Chen, Meng-Tsun Liu, Chu-Hsuan Chiu, Yi-Cheng Chang, Sheng-Nan Chang, Jou-Wei Lin, Juey-Jen Hwang
Publikováno v:
Journal of the Formosan Medical Association, Vol 123, Iss 9, Pp 968-974 (2024)
Background: Exosomes are membrane vesicles that are actively secreted in response to microenvironmental stimuli. In this study, we quantified the amount of exosomes in patients with significant coronary artery disease (CAD) and evaluated its relation
Externí odkaz:
https://doaj.org/article/dc438472a88a4b71a6c4431f5068a99e
Autor:
Cyun-Ming Wu, Hao-Yun Li, Wen-Yi Li, Chih-Neng Hsu, Wei-Shun Yang, Gwo-Tsang Chuang, Tony Pan-Hou Che, Tung-Yuan Lee, Hsiao-Lin Lee, Siow-Wey Hee, Jiin-Horng Lee, Daniel Liao, Karen Chia-Wen Liao, Ya-Wen Liu, Chin-Feng Hsuan, Yi-Cheng Chang, Shao-Lun Chu
Publikováno v:
STAR Protocols, Vol 5, Iss 4, Pp 103478- (2024)
Summary: 2-deoxy-D-glucose (2DG) is a glucose analog converted to 2-deoxy-D-glucose-6-phosphate (2DG-6P) by hexokinase in glycolysis. While 2DG commonly measures glucose uptake, 2DG-6P detects glucose utilization. Here, we present a protocol to measu
Externí odkaz:
https://doaj.org/article/6fa8409ceaf742d5bda1328edb43d9d9
Autor:
Rebecca Keener, Surya B. Chhetri, Carla J. Connelly, Margaret A. Taub, Matthew P. Conomos, Joshua Weinstock, Bohan Ni, Benjamin Strober, Stella Aslibekyan, Paul L. Auer, Lucas Barwick, Lewis C. Becker, John Blangero, Eugene R. Bleecker, Jennifer A. Brody, Brian E. Cade, Juan C. Celedon, Yi-Cheng Chang, L. Adrienne Cupples, Brian Custer, Barry I. Freedman, Mark T. Gladwin, Susan R. Heckbert, Lifang Hou, Marguerite R. Irvin, Carmen R. Isasi, Jill M. Johnsen, Eimear E. Kenny, Charles Kooperberg, Ryan L. Minster, Take Naseri, Satupa’itea Viali, Sergei Nekhai, Nathan Pankratz, Patricia A. Peyser, Kent D. Taylor, Marilyn J. Telen, Baojun Wu, Lisa R. Yanek, Ivana V. Yang, Christine Albert, Donna K. Arnett, Allison E. Ashley-Koch, Kathleen C. Barnes, Joshua C. Bis, Thomas W. Blackwell, Eric Boerwinkle, Esteban G. Burchard, April P. Carson, Zhanghua Chen, Yii-Der Ida Chen, Dawood Darbar, Mariza de Andrade, Patrick T. Ellinor, Myriam Fornage, Bruce D. Gelb, Frank D. Gilliland, Jiang He, Talat Islam, Stefan Kaab, Sharon L. R. Kardia, Shannon Kelly, Barbara A. Konkle, Rajesh Kumar, Ruth J. F. Loos, Fernando D. Martinez, Stephen T. McGarvey, Deborah A. Meyers, Braxton D. Mitchell, Courtney G. Montgomery, Kari E. North, Nicholette D. Palmer, Juan M. Peralta, Benjamin A. Raby, Susan Redline, Stephen S. Rich, Dan Roden, Jerome I. Rotter, Ingo Ruczinski, David Schwartz, Frank Sciurba, M. Benjamin Shoemaker, Edwin K. Silverman, Moritz F. Sinner, Nicholas L. Smith, Albert V. Smith, Hemant K. Tiwari, Ramachandran S. Vasan, Scott T. Weiss, L. Keoki Williams, Yingze Zhang, Elad Ziv, Laura M. Raffield, Alexander P. Reiner, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Hematology and Hemostasis Working Group, TOPMed Structural Variation Working Group, Marios Arvanitis, Carol W. Greider, Rasika A. Mathias, Alexis Battle
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Genome-wide association studies (GWAS) have become well-powered to detect loci associated with telomere length. However, no prior work has validated genes nominated by GWAS to examine their role in telomere length regulation. We conducted a
Externí odkaz:
https://doaj.org/article/3e293e6c932a4a42b553d789d690044b
Association between genetic risk of melatonin secretion and attention deficit hyperactivity disorder
Autor:
Nagahide Takahashi, Tomoko Nishimura, Akemi Okumura, Taeko Harada, Toshiki Iwabuchi, Md Shafiur Rahman, Pi-Hua Liu, Gwo-Tsann Chuang, Yi-Cheng Chang, Yoko Nomura, Kenji J. Tsuchiya
Publikováno v:
Psychiatry Research Communications, Vol 4, Iss 3, Pp 100188- (2024)
Sleep problems are common in individuals with ADHD; however, the exact underlying mechanism is unknown. I Data from the Lundbeck Foundation Initiative for Integrative Psychiatric Research (N = 27,076), the Taiwan Biobank (N = 2373) and the Hamamatsu
Externí odkaz:
https://doaj.org/article/957043c4ada942b69bfaf6c18d68c83d
Autor:
Yi-Cheng Chang, Hsiao-Lin Lee, Wenjin Yang, Meng-Lun Hsieh, Cai-Cin Liu, Tung-Yuan Lee, Jing-Yong Huang, Jiun-Yi Nong, Fu-An Li, Hsiao-Li Chuang, Zhi-Zhong Ding, Wei-Lun Su, Li-Yun Chueh, Yi-Ting Tsai, Che-Hong Chen, Daria Mochly-Rosen, Lee-Ming Chuang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Obesity and type 2 diabetes have reached pandemic proportion. ALDH2 (acetaldehyde dehydrogenase 2, mitochondrial) is the key metabolizing enzyme of acetaldehyde and other toxic aldehydes, such as 4-hydroxynonenal. A missense Glu504Lys mutati
Externí odkaz:
https://doaj.org/article/aa0c7baef0c6434fba0dad49f77f4be3
Autor:
Chu-Hsuan Chiu, Chin-Feng Hsuan, Shih-Hua Lin, Yi-Jen Hung, Chii-Min Hwu, Siow-Wey Hee, Shu-Wha Lin, Sitt-Wai Fong, Patrick Ching-Ho Hsieh, Wei-Shun Yang, Wei-Chou Lin, Hsiao-Lin Lee, Meng-Lun Hsieh, Wen-Yi Li, Jou-Wei Lin, Chih-Neng Hsu, Vin-Cent Wu, Gwo-Tsann Chuang, Yi-Cheng Chang, Lee-Ming Chuang
Publikováno v:
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-16 (2023)
Abstract Background Genome-wide association studies (GWASs) have linked RRBP1 (ribosomal-binding protein 1) genetic variants to atherosclerotic cardiovascular diseases and serum lipoprotein levels. However, how RRBP1 regulates blood pressure is unkno
Externí odkaz:
https://doaj.org/article/1473d84d2c234d35bac7bc2e58e2fe8a
Autor:
Jin-Ying Lu, Horng-Yih Ou, Chung-Ze Wu, Chwen-Yi Yang, Ju-Ying Jiang, Chieh-Hsiang Lu, Yi-Der Jiang, Tien-Jyun Chang, Yi-Cheng Chang, Meng-Lun Hsieh, Wan-Chen Wu, Hung-Yuan Li, Ye-Fong Du, Ching-Han Lin, Hao-Chang Hung, Kai-Jen Tien, Nai-Cheng Yeh, Shang-Yu Lee, Hui-I. Yu, Lee-Ming Chuang
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Transcutaneous electrical nerve stimulator (TENS) has been demonstrated to be beneficial in glycemic control in animal models, but its application in humans has not been well studied. We randomly assigned 160 patients with type 2 diabetes on
Externí odkaz:
https://doaj.org/article/542eea2ca00e430388e82f4b4476fd7b
Autor:
Yi-Cheng Chang, Jan Manent, Jan Schroeder, Siew Fen Lisa Wong, Gabriel M. Hauswirth, Natalia A. Shylo, Emma L. Moore, Annita Achilleos, Victoria Garside, Jose M. Polo, Paul Trainor, Edwina McGlinn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The authors identify Nuclear receptor subfamily 6 group A member 1 (Nr6a1) as a master regulator of elongation, segmentation, patterning and lineage allocation specifically within the trunk region of the mouse, acting downstream of the major signals
Externí odkaz:
https://doaj.org/article/117f96f9c40b48e6a5318dfb51a9856a
Autor:
Siow-Wey Hee, Yi-Cheng Chang, Lynn Su, Ing-Jung Chen, Yung-Ming Jeng, Meng-Lun Hsieh, Yu-Chia Chang, Fu-An Li, Daniel Liao, Shiau-Mei Chen, Lee-Ming Chuang
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107997- (2023)
Summary: 15-keto-PGE2 is one of the eicosanoids with anti-inflammatory properties. In this study, we demonstrated that 15-keto-PGE2 post-translationally modified the nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) subunits p105/p
Externí odkaz:
https://doaj.org/article/412f87713f30478d98d29cbdcee7fa14