Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Yi‐Chin Toh"'
Autor:
Christopher P. Tostado, Lucas Xian Da Ong, Joel Jia Wei Heng, Carlo Miccolis, Shumei Chia, Justine Jia Wen Seow, Yi‐Chin Toh, Ramanuj DasGupta
Publikováno v:
Bioengineering & Translational Medicine, Vol 9, Iss 2, Pp n/a-n/a (2024)
Abstract We present a novel framework combining single‐cell phenotypic data with single‐cell transcriptomic analysis to identify factors underpinning heterogeneity in antitumor immune response. We developed a pairwise, tumor‐immune discretized
Externí odkaz:
https://doaj.org/article/e3f6aac3aa424acea62575b13eedc419
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108497- (2023)
Summary: Mutations in the human fasciculation and elongation protein zeta 1 (FEZ1) gene are found in schizophrenia and Jacobsen syndrome patients. Here, using human cerebral organoids (hCOs), we show that FEZ1 expression is turned on early during bra
Externí odkaz:
https://doaj.org/article/504a8ead714046b990e3be8500e0ce00
Publikováno v:
Bioengineering, Vol 11, Iss 4, p 315 (2024)
Traditional eye irritation assessments, which rely on animal models or ex vivo tissues, face limitations due to ethical concerns, costs, and low throughput. Although numerous in vitro tests have been developed, none have successfully reconciled the n
Externí odkaz:
https://doaj.org/article/177f71d225ee42e2ac8b8b9f55bfaf0d
Autor:
Louis Jun Ye Ong, Shumei Chia, Stephen Qi Rong Wong, Xiaoqian Zhang, Huiwen Chua, Jia Min Loo, Wei Yong Chua, Clarinda Chua, Emile Tan, Hannes Hentze, Iain Beehuat Tan, Ramanuj DasGupta, Yi-Chin Toh
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Inter-patient and intra-tumour heterogeneity (ITH) have prompted the need for a more personalised approach to cancer therapy. Although patient-derived xenograft (PDX) models can generate drug response specific to patients, they are not sustainable in
Externí odkaz:
https://doaj.org/article/85f6517cb8294c69a16c75eda4b57a62
Autor:
Jorge A. Cataño, Steven Farthing, Zeus Mascarenhas, Nathaniel Lake, Prasad K. D. V. Yarlagadda, Zhiyong Li, Yi-Chin Toh
Publikováno v:
Micromachines, Vol 14, Iss 5, p 930 (2023)
Microfluidic organ-on-a-chip (OoC) technology has enabled studies on dynamic physiological conditions as well as being deployed in drug testing applications. A microfluidic pump is an essential component to perform perfusion cell culture in OoC devic
Externí odkaz:
https://doaj.org/article/c26bc2b734ae42aba9d6cda5597bc685
Publikováno v:
Cells, Vol 12, Iss 4, p 579 (2023)
Osteoarthritis (OA) remains a prevalent disease affecting more than 20% of the global population, resulting in morbidity and lower quality of life for patients. The study of OA pathophysiology remains predominantly in animal models due to the complex
Externí odkaz:
https://doaj.org/article/0ade9b21e876458e8472f38357bc3f1c
Autor:
Terry Ching, Jyothsna Vasudevan, Hsih Yin Tan, Chwee Teck Lim, Javier Fernandez, Yi-Chin Toh, Michinao Hashimoto
Publikováno v:
HardwareX, Vol 10, Iss , Pp e00202- (2021)
Commercially available peristaltic pumps for microfluidics are usually bulky, expensive, and not customizable. Herein, we developed a cost-effective kit to build a micro-peristaltic pump (~ 50 USD) consisting of 3D-printed and off-the-shelf component
Externí odkaz:
https://doaj.org/article/24ca9a65d2f4459ab23c684cfcb73985
Autor:
Geetika Sahni, Shu‐Yung Chang, Jeremy Choon Meng Teo, Jerome Zu Yao Tan, Jean Jacques Clement Fatien, Carine Bonnard, Kagistia Hana Utami, Puck Wee Chan, Thong Teck Tan, Umut Altunoglu, Hülya Kayserili, Mahmoud Pouladi, Bruno Reversade, Yi‐Chin Toh
Publikováno v:
Advanced Science, Vol 8, Iss 13, Pp n/a-n/a (2021)
Externí odkaz:
https://doaj.org/article/124cb9bd77d24377b9cd9c1a0ea5bb3c
Autor:
Lor Huai Chong, Celine Ng, Huan Li, Edmund Feng Tian, Abhishek Ananthanarayanan, Michael McMillian, Yi-Chin Toh
Publikováno v:
ACS Omega, Vol 4, Iss 9, Pp 13902-13912 (2019)
Externí odkaz:
https://doaj.org/article/0feef7ec061049d9b2db692f1537bee3
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 7 (2019)
Endothelial cells (ECs) are required for a multitude of cardiovascular clinical applications, such as revascularization of ischemic tissues or endothelialization of tissue engineered grafts. Patient derived primary ECs are limited in number, have don
Externí odkaz:
https://doaj.org/article/22e2bd51a6a24e5598bcafb019769232