Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Yhun Yhong Sheen"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Radio-resistance resulting from radiotherapy-induced fibrosis is a major clinical obstacle in breast cancer treatment because it typically leads to cancer recurrence, treatment failure, and patient death. Transforming growth factor-β (TGF-
Externí odkaz:
https://doaj.org/article/f305aad512fa4b179163b01a30e01964
Autor:
Min-Jin Kim, Sang-A Park, Chun Hwa Kim, So-Yeon Park, Jung-Shin Kim, Dae-Kee Kim, Jeong-Seok Nam, Yhun Yhong Sheen
Publikováno v:
Cellular Physiology and Biochemistry, Vol 38, Iss 2, Pp 571-588 (2016)
Background/Aims: Hypoxia is an environmental factor that aggravates liver fibrosis. HIF1α activates hepatic stellate cells (HSCs) and increases transforming growth factor-β (TGF-β) signaling and the epithelial mesenchymal transition (EMT), acceler
Externí odkaz:
https://doaj.org/article/aa1967a19fd447b5a3ed5d4bab9e9129
Autor:
Yhun Yhong Sheen, Jeong-Seok Nam, Dae-Kee Kim, Seung Won Kim, Min-Jin Kim, Sang-A. Park, Seon Joo Lee, Sol-Ji Kim, So-Yeon Park, Ji Yeon Son
PDF - 120K, (A) Blockade of Smad2 phosphorylation by various ALK5 inhibitors. 4T1 cells starved in 0.2% HI-FBS medium for 24 h, and were treated with the indicated chemicals for 2 h with or without TGF-beta1 (2 ng/ml) in 0.2% HI-FBS medium. (B, C) Bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a56469422ad4dbca5683b90402ba3c
https://doi.org/10.1158/1535-7163.22500451
https://doi.org/10.1158/1535-7163.22500451
Autor:
Yhun Yhong Sheen, Jeong-Seok Nam, Dae-Kee Kim, Seung Won Kim, Min-Jin Kim, Sang-A. Park, Seon Joo Lee, Sol-Ji Kim, So-Yeon Park, Ji Yeon Son
PDF - 430K, Inhibitory effects of various ALK5 inhibitors on TGF−beta1-induced EMT in MCF10A cells. MCF10A cells were treated with TGF−beta1 (2 ng/ml) for 96 h in serum-reduced media (1% heat inactivated-horse serum (HI-HS)) in the presence or ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4388ca69cd225a52905e366d28edcc2f
https://doi.org/10.1158/1535-7163.22500442
https://doi.org/10.1158/1535-7163.22500442
Autor:
Yhun Yhong Sheen, Jeong-Seok Nam, Dae-Kee Kim, Seung Won Kim, Min-Jin Kim, Sang-A. Park, Seon Joo Lee, Sol-Ji Kim, So-Yeon Park, Ji Yeon Son
Advanced tumors produce an excessive amount of transforming growth factor β (TGFβ), which promotes tumor progression at late stages of malignancy. The purpose of this study was to develop anti-TGFβ therapeutics for cancer. We synthesized a novel s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d1abfc6deac3955c68992fc299cbfe6
https://doi.org/10.1158/1535-7163.c.6536452
https://doi.org/10.1158/1535-7163.c.6536452
Autor:
Yhun Yhong Sheen, Jeong-Seok Nam, Dae-Kee Kim, Seung Won Kim, Min-Jin Kim, Sang-A. Park, Seon Joo Lee, Sol-Ji Kim, So-Yeon Park, Ji Yeon Son
PDF - 80K, (A, B) Breast cancer model #6 (described in the Material and Methods). (A) Inhibition of lung metastasis by EW-7197 was evaluated by analysis of luciferase activity in lungs of 4T1-luc orthotropic xenograft mice. Statistical significance w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49c026f34717b09e5964a664c288353
https://doi.org/10.1158/1535-7163.22500433
https://doi.org/10.1158/1535-7163.22500433
Autor:
Yhun Yhong Sheen, Jeong-Seok Nam, Dae-Kee Kim, Seung Won Kim, Min-Jin Kim, Sang-A. Park, Seon Joo Lee, Sol-Ji Kim, So-Yeon Park, Ji Yeon Son
PDF - 191K, Supplementary materials and methods and supplementary figure legends. Supplementary Table 1. Antibodies for Western blot analysis. Supplementary Table 2. Primers for qRT-PCR or RT-PCR. Supplementary Table 3. Radiometric protein kinase ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5691ccedabaf6b81ab2fe99ed129dd66
https://doi.org/10.1158/1535-7163.22500430.v1
https://doi.org/10.1158/1535-7163.22500430.v1
Autor:
Yhun Yhong Sheen, Jeong-Seok Nam, Dae-Kee Kim, Seung Won Kim, Min-Jin Kim, Sang-A. Park, Seon Joo Lee, Sol-Ji Kim, So-Yeon Park, Ji Yeon Son
PDF - 150K, Inhibitory effects of various ALK5 inhibitors on TGFbeta1-induced EMT in MCF10A cells. MCF10A cells were treated with TGFbeta1 (2 ng/ml) for 96 h in serum-reduced media (1% HI-HS) in the presence or absence of the indicated ALK5 inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bb7b75220eea409ff9ea0bfa9044145
https://doi.org/10.1158/1535-7163.22500439.v1
https://doi.org/10.1158/1535-7163.22500439.v1
Autor:
Yhun Yhong Sheen, Jeong-Seok Nam, Dae-Kee Kim, Seung Won Kim, Min-Jin Kim, Sang-A. Park, Seon Joo Lee, Sol-Ji Kim, So-Yeon Park, Ji Yeon Son
PDF - 356K, (A~C) Breast cancer model #1, described in the Material and Methods. (A) Effect of EW-7197 on lung metastasis of breast cancer in MMTV-c/Neu mice. Representative images of H&E stained lungs (total magnification: x 12.5 or 100, scale bar:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::632618b312a7f47e5e3bd493a0e37ad1
https://doi.org/10.1158/1535-7163.22500436.v1
https://doi.org/10.1158/1535-7163.22500436.v1
Publikováno v:
Therapeutic Innovation & Regulatory Science. 53:233-242
Globalization of the pharmaceutical industry has continued over the past few decades, and various regulatory authorities have put considerable effort into harmonizing and standardizing drug regulations. However, the regulatory practices of each regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1259a6ef5100478d26324f2293db9f3e
https://doi.org/10.1177/2168479018769301
https://doi.org/10.1177/2168479018769301