Výsledky vyhledávání - "Yewdell, J. W."

Defective ribosomal products (DRiPs): a major source of antigenic peptides for MHC class I molecules?

Autor: Yewdell, J. W., Luis C. Antón, Bennink, J. R.

Publikováno v: Scopus-Elsevier

MHC class I molecules predominantly bind to peptides derived from a cytosolic pool of polypeptides. Little is known about the nature of the polypeptides that serve as substrates for peptidogenic cytosolic proteases. We propose that a significant sour

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::734a5009ccc3aa66a53118196e1ae101
https://doi.org/10.4049/jimmunol.157.5.1823

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TAP (transporter associated with antigen processing)-independent presentation of endogenously synthesized peptides is enhanced by endoplasmic reticulum insertion sequences located at the amino- but not carboxyl-terminus of the peptide

Autor: Bacik, I., Josephine Cox, Anderson, R., Yewdell, J. W., Bennink, J. R.

Publikováno v: Scopus-Elsevier

Under most circumstances, cell surface MHC class I molecules display peptides derived from a cytosolic pool of proteins. The efficient presentation of such peptides requires the functioning of two MHC gene products [TAP1 and TAP2 (transporter-associa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf19bfe602e8fb08b08468bf8ce26561
https://doi.org/10.4049/jimmunol.152.2.381

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Detection of shared MHC-restricted human melanoma antigens after vaccinia virus-mediated transduction of genes coding for HLA

Autor: O Neil, B. H., Kawakami, Y., Nicholas P. Restifo, Bennink, J. R., Yewdell, J. W., Rosenberg, S. A.

Publikováno v: Scopus-Elsevier

To detect shared human melanoma Ag that are recognized by HLA-A2 restricted, melanoma-specific CTL derived from tumor infiltrating lymphocytes, we have developed a convenient method to insert and express foreign HLA genes capable of presenting Ag on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bc0f85c6e1c188bcba33f49754bb436
https://doi.org/10.4049/jimmunol.151.3.1410

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Defective presentation of endogenous antigens by a murine sarcoma. Implications for the failure of an anti-tumor immune response

Autor: Nicholas P. Restifo, Esquivel, F., Asher, A. L., Stötter, H., Barth, R. J., Bennink, J. R., Mulé, J. J., Yewdell, J. W., Rosenberg, S. A.

Publikováno v: Scopus-Elsevier

MHC class I-restricted CTL play a central role in the immune response against methylcholanthrene (MCA)-induced sarcomas in mice. We, therefore, hypothesized that MCA-induced tumors may evade immune recognition by failing to present Ag to CD8+ CTL. Of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c7e52f93e0efb6f346a4b0e6f925b35
https://doi.org/10.4049/jimmunol.147.4.1453

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Assembly of MHC class I molecules with biosynthesized endoplasmic reticulum-targeted peptides is inefficient in insect cells and can be enhanced by protease inhibitors

Autor: Deng, Y., Gibbs, J., Bačík, I., Porgador, A., Copeman, J., Paul Joseph Lehner, Ortmann, B., Cresswell, P., Bennink, J. R., Yewdell, J. W.

Publikováno v: Scopus-Elsevier

To study the requirements for assembly of MHC class I molecules with antigenic peptides in the endoplasmic reticulum (ER), we studied Ag processing in insect cells. Insects lack a class I recognition system, and their cells therefore provide a “bla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b7d8aab1818fe91f092a5d522fb24c
https://pubmed.ncbi.nlm.nih.gov/9712031

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