Výsledky vyhledávání - "Yevgeniy Freyvert"

A novel scoring system concept for de novo spinal infection treatment, the Spinal Infection Treatment Evaluation Score (SITE Score): a proof-of-concept study

Autor: Jonathan Pluemer, Yevgeniy Freyvert, Nathan Pratt, Jerry E. Robinson, Jared A. Cooke, Zachary L. Tataryn, Clifford A. Pierre, Periklis Godolias, Sven Frieler, Alexander von Glinski, Emre Yilmaz, Zeyad A. Daher, Hamzah A. Al-Awadi, Mitchell H. Young, Rod J. Oskouian, Jens R. Chapman

Publikováno v: Journal of Neurosurgery: Spine. 38:396-404

OBJECTIVE De novo infections of the spine are an increasing healthcare problem. The decision for nonsurgical or surgical treatment is often made case by case on the basis of physician experience, specialty, or practice affiliation rather than evidenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0dbd87f66979a6c2882fe1b7d737fded
https://doi.org/10.3171/2022.11.spine22719

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An Assessment of the Safety of Surgery and Hardware Placement in de-novo Spinal Infections. A Systematic Review and Meta-Analysis of the Literature

Autor: Jonathan Pluemer, Yevgeniy Freyvert, Nathan Pratt, Jerry E Robinson, Jared A Cooke, Zachary L Tataryn, Periklis Godolias, Zeyad A Daher, Rod J. Oskouian, Jens R. Chapman

Publikováno v: Global spine journal.

Objectives Primary objectives were outcomes comparison of instrumented surgery used for de-novo spinal infections in terms of infection recurrence, reoperations, primary failure, mortality, and length of stay relative to non-instrumented surgery. Sec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3b272fed431ae5dad47f0940325b365
https://pubmed.ncbi.nlm.nih.gov/36510352

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Engaging cervical spinal circuitry with non-invasive spinal stimulation and buspirone to restore hand function in chronic motor complete patients

Autor: Yury Gerasimenko, Yevgeniy Freyvert, Erika Morikawa, V. Reggie Edgerton, Daniel C. Lu, Sharon Zdunowski, Melanie E. Sarino, Nicholas Au Yong

Publikováno v: Scientific reports, vol 8, iss 1
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports

The combined effects of cervical electrical stimulation alone or in combination with the monoaminergic agonist buspirone on upper limb motor function were determined in six subjects with motor complete (AIS B) injury at C5 or above and more than one

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c56c27f15e7e0884704a8c658985760b
https://escholarship.org/uc/item/9mx518n7

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Highly efficient deletion of FUT8 in CHO cell lines using zinc-finger nucleases yields cells that produce completely nonfucosylated antibodies

Autor: Laetitia Malphettes, Zhe Zhou, Jennifer Chang, Jeffrey C. Miller, Thu Nguyen, Christina Tsai, Trevor Collingwood, Pei-Qi Liu, Yevgeniy Freyvert, Edmond Chan, Andrew Snowden, Philip D. Gregory, Gregory J. Cost

Publikováno v: Biotechnology and Bioengineering. 106:774-783

IgG1 antibodies produced in Chinese hamster ovary (CHO) cells are heavily alpha1,6-fucosylated, a modification that reduces antibody-dependent cellular cytotoxicity (ADCC) and can inhibit therapeutic antibody function in vivo. Addition of fucose is c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c8dd9b3604956279bee12a52f8e0c0
https://doi.org/10.1002/bit.22751

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Tissue Damage by Pulsed Electrical Stimulation

Autor: Daniel Palanker, Alexander Vankov, A. Butterwick, Yevgeniy Freyvert, P. Huie

Publikováno v: IEEE Transactions on Biomedical Engineering. 54:2261-2267

Repeated pulsed electrical stimulation is used in a multitude of neural interfaces; damage resulting from such stimulation was studied as a function of pulse duration, electrode size, and number of pulses using a fluorescent assay on chick chorioallo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28349d98c241d46b4c8daf50ffc14818
https://doi.org/10.1109/tbme.2007.908310

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In vivo cleavage of transgene donors promotes nuclease-mediated targeted integration

Autor: Yolanda Santiago, Yevgeniy Freyvert, Sandra Cristea, Philip D. Gregory, Michael C. Holmes, Fyodor D. Urnov, Gregory J. Cost

Publikováno v: Biotechnology and bioengineering. 110(3)

Targeted DNA integration is commonly used to eliminate position effects on transgene expression. Integration can be targeted to specific sites in the genome via both homology-based and homology-independent processes. Both pathways start the integrati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1bb6b20664152783594c5f4c953785e
https://pubmed.ncbi.nlm.nih.gov/23042119

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BAK and BAX deletion using zinc-finger nucleases yields apoptosis-resistant CHO cells

Autor: Annamaria Vafiadis, Edward J. Rebar, Jeffrey C. Miller, Andrew Snowden, Trevor Collingwood, Yolanda Santiago, Philip D. Gregory, Yevgeniy Freyvert, Gregory J. Cost

Publikováno v: Biotechnology and bioengineering. 105(2)

Anoxic and metabolic stresses in large-scale cell culture during biopharmaceutical production can induce apoptosis. Strategies designed to ameliorate the problem of apoptosis in cell culture have focused on mRNA knockdown of pro-apoptotic proteins an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c786afa14b437c4cc4981f44129037da
https://pubmed.ncbi.nlm.nih.gov/19777580

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Knockout rats via embryo microinjection of zinc-finger nucleases

Publikováno v: Science (New York, N.Y.). 325(5939)

The toolbox of rat genetics currently lacks the ability to introduce site-directed, heritable mutations into the genome to create knockout animals. By using engineered zinc-finger nucleases (ZFNs) designed to target an integrated reporter and two end

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8dfde293036e526492b11e92ebd5362
https://pubmed.ncbi.nlm.nih.gov/19628861

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Zinc-finger nuclease-driven targeted integration into mammalian genomes using donors with limited chromosomal homology

Autor: Philip D. Gregory, James Li, Erica A. Moehle, Salvatore J. Orlando, Yevgeniy Freyvert, Vivian M. Choi, Gregory J. Cost, Jeffrey C. Miller, Sunita Gopalan, Elizabeth A. Boydston, Michael C. Holmes, Fyodor D. Urnov, Russell Dekelver, Yolanda Santiago, Jacqueline F. Lou

Publikováno v: Nucleic Acids Research

We previously demonstrated high-frequency, targeted DNA addition mediated by the homology-directed DNA repair pathway. This method uses a zinc-finger nuclease (ZFN) to create a site-specific double-strand break (DSB) that facilitates copying of genet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297d029497ae0425ad17069c164a72c5
http://europepmc.org/articles/PMC2926620

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