Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Yevgeniy Freyman"'
Autor:
Karah Nazor Friberg, Gene Hung, Ed Wancewicz, Kurt Giles, Chris Black, Sue Freier, Frank Bennett, Stephen J DeArmond, Yevgeniy Freyman, Pierre Lessard, Sina Ghaemmaghami, Stanley B Prusiner
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 1, Iss C (2012)
Mice deficient for the cellular prion protein (PrPC) do not develop prion disease; accordingly, gene-based strategies to diminish PrPC expression are of interest. We synthesized a series of chemically modified antisense oligonucleotides (ASOs) target
Externí odkaz:
https://doaj.org/article/e903ab1e0ba844ac9d3324d05a35cd78
Autor:
Kimberline Y. Gerrick, Jenny Laraio, Kelsey Annen, Hoang Tran, Marcus M. Fischer, Yevgeniy Freyman, Geeta Sharma, Isaac Bishof, Stephen Federowicz, Divya Pankajakshan, Claire L. Neilan, Biju Mangatt, Anthony Mazurek, Mark R. Lackner, Michael White, Zineb Mounir
Publikováno v:
Cancer Research. 83:1637-1637
Methylthioadenosine phosphorylase (MTAP) is co-deleted with the tumor suppressor CDKN2A in approximately 15% of solid tumors and can elicit dependency on methionine adenosyltransferase 2A (MAT2A) production of S-adenosyl methionine (SAM), the major m
Autor:
Marcus M. Fischer, Kimberline Gerrick, Brian Belmontes, Katherine Slemmons, Yevgeniy Freyman, Jay Jain, Steve Federowicz, Isaac Bishof, Arjun A. Rao, Melissa Fleury, Zineb Mounir, Mark R. Lackner, Paul E. Hughes, Mike White, Claire L. Neilan
Publikováno v:
Cancer Research. 83:1644-1644
Approximately 15% of all tumors harbor deletions in the 9p21 locus that encompass CDKN2A and MTAP. MTAP fuels the adenine and methionine salvage pathways by converting MTA into precursors of building blocks for protein and DNA production. In MTAP-del
Autor:
Zineb Mounir, Claire Neilan, Bing Yao, Marcus Fischer, Yevgeniy Freyman, Neil E. Bhola, Mark R. Lackner, John Faulhaber
Publikováno v:
Cancer Research. 81:1278-1278
Background: Approximately 15% of all solid tumors harbor deletions in methylthioadenosine phosphorylase (MTAP) (1). MTAP deficiencies have been reported to sensitize tumor cells to methionine adenosyltransferase 2A (MAT2A) modulation (2). MAT2A synth
Autor:
Glenda M. Halliday, Smita Patel, Daniel A. Mordes, Sabeen A. Kazmi, Lefkos T. Middleton, Atsushi Aoyagi, Steve M. Gentleman, Stanley B. Prusiner, Yevgeniy Freyman, Steven H. Olson, Abby Oehler, Amanda L. Woerman
Publikováno v:
Acta neuropathologica, vol 135, iss 1
Woerman, AL; Kazmi, SA; Patel, S; Freyman, Y; Oehler, A; Aoyagi, A; et al.(2018). MSA prions exhibit remarkable stability and resistance to inactivation. ACTA NEUROPATHOLOGICA, 135(1), 49-63. doi: 10.1007/s00401-017-1762-2. UCSF: Retrieved from: http://www.escholarship.org/uc/item/16q2x34d
Woerman, AL; Kazmi, SA; Patel, S; Freyman, Y; Oehler, A; Aoyagi, A; et al.(2018). MSA prions exhibit remarkable stability and resistance to inactivation. ACTA NEUROPATHOLOGICA, 135(1), 49-63. doi: 10.1007/s00401-017-1762-2. UCSF: Retrieved from: http://www.escholarship.org/uc/item/16q2x34d
In multiple system atrophy (MSA), progressive neurodegeneration results from the protein α-synuclein misfolding into a self-templating prion conformation that spreads throughout the brain. MSA prions are transmissible to transgenic (Tg) mice express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6218c86f93bbc1d55a0a5c55698288b
https://escholarship.org/uc/item/16q2x34d
https://escholarship.org/uc/item/16q2x34d
Autor:
Robert Cotter, Julian A. Castaneda, Steven H. Olson, Abby Oehler, Sabeen A. Kazmi, Stanley B. Prusiner, Smita S. Patel, Lloyd Espiritu, Yevgeniy Freyman, Amanda L. Woerman
Publikováno v:
JAMA neurology, vol 74, iss 12
Importance:Accumulation of the protein tau is a defining characteristic of several neurodegenerative diseases. Thorough assessment of transgenic (Tg) mouse lines that replicate this process is critical for establishing the models used for testing ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9107afe9a641e2aedfa599c83e7daf27
https://europepmc.org/articles/PMC5822201/
https://europepmc.org/articles/PMC5822201/
Autor:
Zhe Li, Casper Wong, Joel R. Gever, Kurt Giles, Kartika Widjaja, Satish Rao, Matthew P. Jacobson, Yevgeniy Freyman, Adam R. Renslo, Manuel Elepano, Stanley B. Prusiner, John J. Irwin, B. Michael Silber
Publikováno v:
Bioorganic & medicinal chemistry, vol 22, iss 6
Silber, BM; Gever, JR; Rao, S; Li, Z; Renslo, AR; Widjaja, K; et al.(2014). Novel compounds lowering the cellular isoform of the human prion protein in cultured human cells. Bioorganic and Medicinal Chemistry, 22(6), 1960-1972. doi: 10.1016/j.bmc.2014.01.001. UCSF: Retrieved from: http://www.escholarship.org/uc/item/5r2396fv
Silber, BM; Gever, JR; Rao, S; Li, Z; Renslo, AR; Widjaja, K; et al.(2014). Novel compounds lowering the cellular isoform of the human prion protein in cultured human cells. Bioorganic and Medicinal Chemistry, 22(6), 1960-1972. doi: 10.1016/j.bmc.2014.01.001. UCSF: Retrieved from: http://www.escholarship.org/uc/item/5r2396fv
Purpose: Previous studies showed that lowering PrPC concomitantly reduced PrPSc in the brains of mice inoculated with prions. We aimed to develop assays that measure PrPC on the surface of human T98G glioblastoma and IMR32 neuroblastoma cells. Using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c464fd6f59b5218affb72b4a8c4a6d8
https://escholarship.org/uc/item/5r2396fv
https://escholarship.org/uc/item/5r2396fv
Autor:
Yevgeniy Freyman, Yong Huang, Joel R. Gever, Kimberly L. Fife, Alejandra Gallardo-Godoy, Stanley B. Prusiner, Zhe Li, Leslie Z. Benet, Adam R. Renslo, Matthew P. Jacobson, Kurt Giles, Deepak Dalvie, Manuel Elepano, Satish Rao, B. Michael Silber
Publikováno v:
Pharmaceutical research, vol 30, iss 4
Silber, BM; Rao, S; Fife, KL; Gallardo-Godoy, A; Renslo, AR; Dalvie, DK; et al.(2013). Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice. Pharmaceutical Research, 30(4), 932-950. doi: 10.1007/s11095-012-0912-4. UCSF: Retrieved from: http://www.escholarship.org/uc/item/3j02v3x5
Silber, BM; Rao, S; Fife, KL; Gallardo-Godoy, A; Renslo, AR; Dalvie, DK; et al.(2013). Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice. Pharmaceutical Research, 30(4), 932-950. doi: 10.1007/s11095-012-0912-4. UCSF: Retrieved from: http://www.escholarship.org/uc/item/3j02v3x5
Purpose: To discover drugs lowering PrPScin prion-infected cultured neuronal cells that achieve high concentrations in brain to test in mouse models of prion disease and then treat people with these fatal diseases. Methods: We tested 2-AMT analogs fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4871cc7c62597700be6fc53a6ee2be6c
https://escholarship.org/uc/item/3j02v3x5
https://escholarship.org/uc/item/3j02v3x5
Autor:
Jiri G. Safar, Yevgeniy Freyman, Gültekin Tamgüney, Frederic Letessier, Stanley B. Prusiner, Camille Deering, Stephen J. DeArmond, Pierre Lessard
In chronic wasting disease (CWD) in cervids and in scrapie in sheep, prions appear to be transmitted horizontally. Oral exposure to prion-tainted blood, urine, saliva, and feces has been suggested as the mode of transmission of CWD and scrapie among
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::032550121315d68f5a3fb20d474af5a9
https://europepmc.org/articles/PMC2803675/
https://europepmc.org/articles/PMC2803675/
Autor:
David Peretz, Julie Vergara, Stephen J. DeArmond, Charles E. McCulloch, Stanley B. Prusiner, David V. Glidden, Yevgeniy Freyman, Surachai Supattapone, Kurt Giles, Michael R. Scott, Hoang Oanh B Nguyen, Pierre Lessard, Jiri G. Safar
Prompted by the discovery that prions become protease-sensitive after exposure to branched polyamine dendrimers in acetic acid (AcOH) (S. Supattapone, H. Wille, L. Uyechi, J. Safar, P. Tremblay, F. C. Szoka, F. E. Cohen, S. B. Prusiner, and M. R. Sco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca9639a4e4b6dca40d3d17a5161ca75d
https://europepmc.org/articles/PMC1317507/
https://europepmc.org/articles/PMC1317507/