Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Yevgen Yudin"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Mechanosensitive PIEZO2 ion channels play roles in touch, proprioception, and inflammatory pain. Currently, there are no small molecule inhibitors that selectively inhibit PIEZO2 over PIEZO1. The TMEM120A protein was shown to inhibit PIEZO2
Externí odkaz:
https://doaj.org/article/4ee9d394b91046eea2d8b6cd0bf1f855
Publikováno v:
eLife, Vol 9 (2020)
Transient Receptor Potential Melastatin 3 (TRPM3) is a Ca2+ permeable non-selective cation channel activated by heat and chemical agonists such as pregnenolone sulfate and CIM0216. TRPM3 mutations in humans were recently reported to be associated wit
Externí odkaz:
https://doaj.org/article/755e702f625d43f7834d06532b971fa8
Autor:
Taylor ET Hughes, John Smith Del Rosario, Abhijeet Kapoor, Aysenur Torun Yazici, Yevgen Yudin, Edwin C Fluck III, Marta Filizola, Tibor Rohacs, Vera Y Moiseenkova-Bell
Publikováno v:
eLife, Vol 8 (2019)
Transient receptor potential vanilloid 5 (TRPV5) is a highly calcium selective ion channel that acts as the rate-limiting step of calcium reabsorption in the kidney. The lack of potent, specific modulators of TRPV5 has limited the ability to probe th
Externí odkaz:
https://doaj.org/article/a82f5f6720e94648810a1aa64e4d1450
Autor:
Ruth A Pumroy, Amrita Samanta, Yuhang Liu, Taylor ET Hughes, Siyuan Zhao, Yevgen Yudin, Tibor Rohacs, Seungil Han, Vera Y Moiseenkova-Bell
Publikováno v:
eLife, Vol 8 (2019)
Transient receptor potential vanilloid 2 (TRPV2) plays a critical role in neuronal development, cardiac function, immunity, and cancer. Cannabidiol (CBD), the non-psychotropic therapeutically active ingredient of Cannabis sativa, is an activator of T
Externí odkaz:
https://doaj.org/article/52c5f3354b914f85a92f15afe3f9c2f4
Autor:
Doreen Badheka, Yevgen Yudin, Istvan Borbiro, Cassandra M Hartle, Aysenur Yazici, Tooraj Mirshahi, Tibor Rohacs
Publikováno v:
eLife, Vol 6 (2017)
Transient receptor potential melastatin 3 (TRPM3) channels are activated by heat, and chemical ligands such as pregnenolone sulphate (PregS) and CIM0216. Here, we show that activation of receptors coupled to heterotrimeric Gi/o proteins inhibits TRPM
Externí odkaz:
https://doaj.org/article/36cbe4af6ef947a09f96415068432824
Autor:
Chike Cao, Yevgen Yudin, Yann Bikard, Wei Chen, Tong Liu, Hong Li, Dieter Jendrossek, Alejandro Cohen, Evgeny Pavlov, Tibor Rohacs, Eleonora Zakharian
Publikováno v:
Cell Reports, Vol 4, Iss 2, Pp 302-315 (2013)
The TRPM8 ion channel is expressed in sensory neurons and is responsible for sensing environmental cues, such as cold temperatures and chemical compounds, including menthol and icilin. The channel functional activity is regulated by various physical
Externí odkaz:
https://doaj.org/article/b71b0dc9c68c46f78119db6e3547693a
Publikováno v:
Methods Enzymol
Methods in Enzymology ISBN: 9780323853743
Methods in Enzymology ISBN: 9780323853743
Ion channel are embedded in the lipid bilayers of biological membranes. Membrane phospholipids constitute a barrier to ion movement, and they have been considered for a long time as a passive environment for channel proteins. Membrane phospholipids,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e7402bb54534fdf9453005de1ce14bf
https://pubmed.ncbi.nlm.nih.gov/34059290
https://pubmed.ncbi.nlm.nih.gov/34059290
Publikováno v:
Biophysical Journal. 121:387a-388a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fba0ca3ee7bb14daa45aab058be0a6bb
https://doi.org/10.1016/j.bpj.2021.11.831
https://doi.org/10.1016/j.bpj.2021.11.831
Publikováno v:
The Journal of Neuroscience. 39:6067-6080
The cold- and menthol-sensitive transient receptor potential melastatin 8 (TRPM8) channel is important for both physiological temperature detection and cold allodynia. Activation of G-protein-coupled receptors (GPCRs) by proinflammatory mediators inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f90b1054f21bee27cb4a9b82c76c9b
https://doi.org/10.1523/jneurosci.2304-18.2019
https://doi.org/10.1523/jneurosci.2304-18.2019
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
Transient Receptor Potential Melastatin 3 (TRPM3) is a Ca2+ permeable non-selective cation channel activated by heat and chemical agonists such as pregnenolone sulfate and CIM0216. TRPM3 mutations in humans were recently reported to be associated wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9335dec7f7cf68bee68145700ca93c20
https://doi.org/10.7554/elife.55634
https://doi.org/10.7554/elife.55634