Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Yevgen Levdansky"'
Autor:
Alicia A. Bicknell, David W. Reid, Marissa C. Licata, Adriana K. Jones, Yi Min Cheng, Mengying Li, Chiaowen Joyce Hsiao, Christopher S. Pepin, Mihir Metkar, Yevgen Levdansky, Brian R. Fritz, Elizaveta A. Andrianova, Ruchi Jain, Eugene Valkov, Caroline Köhrer, Melissa J. Moore
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114098- (2024)
Summary: Developing an effective mRNA therapeutic often requires maximizing protein output per delivered mRNA molecule. We previously found that coding sequence (CDS) design can substantially affect protein output, with mRNA variants containing more
Externí odkaz:
https://doaj.org/article/7b3fb817ec414bcf9bdcba69344c3e0c
Autor:
Yevgen Levdansky, Tobias Raisch, Justin C. Deme, Filip Pekovic, Hans Elmlund, Susan M. Lea, Eugene Valkov
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-8 (2023)
Abstract NOT1, NOT10, and NOT11 form a conserved module in the CCR4-NOT complex, critical for post-transcriptional regulation in eukaryotes, but how this module contributes to the functions of the CCR4-NOT remains poorly understood. Here, we present
Externí odkaz:
https://doaj.org/article/5824b314baae41ec8c157763276b6d09
Autor:
Fabian Poetz, Joshua Corbo, Yevgen Levdansky, Alexander Spiegelhalter, Doris Lindner, Vera Magg, Svetlana Lebedeva, Jörg Schweiggert, Johanna Schott, Eugene Valkov, Georg Stoecklin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The CCR4-NOT complex is a key regulator of eukaryotic mRNA deadenylation. Here the authors identified the E3 ubiquitin ligase RNF219 as an acetylation-regulated cofactor of the complex, which inhibits mRNA decay through a direct interaction with NOT9
Externí odkaz:
https://doaj.org/article/cc351c576ed24cd3accc3acb79dbb617
Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation
Autor:
Tobias Raisch, Chung-Te Chang, Yevgen Levdansky, Sowndarya Muthukumar, Stefan Raunser, Eugene Valkov
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The CCR4-NOT complex shortens poly(A) tails of messenger RNAs. By biochemical reconstitution of the entire human CCR4-NOT complex, the authors show the stimulatory roles of non-enzymatic subunits and the importance of the interaction between CAF40 an
Externí odkaz:
https://doaj.org/article/0d6ba84b2a914940b58d2a4de867487b
Autor:
David Buchta, Tibor Füzik, Dominik Hrebík, Yevgen Levdansky, Lukáš Sukeník, Liya Mukhamedova, Jana Moravcová, Robert Vácha, Pavel Plevka
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Genome release of enteroviruses relies on exposure to acidic pH, but the mechanism of uncoating remains unclear. Here, Buchta et al. show that echovirus 18 loses one to three adjacent capsid-protein pentamers, resulting in an opening of more than 120
Externí odkaz:
https://doaj.org/article/2dfed097c8834689b127851bd87cfefd
Autor:
Cátia Igreja, Ying Chen, Lara Wohlbold, Ramona Weber, Dipankar Bhandari, Eugene Valkov, Chung Te Chang, Yevgen Levdansky, Sowndarya Muthukumar, Elisa Izaurralde
Publikováno v:
Nucleic Acids Research
XRN1 is the major cytoplasmic exoribonuclease in eukaryotes, which degrades deadenylated and decapped mRNAs in the last step of the 5′–3′ mRNA decay pathway. Metazoan XRN1 interacts with decapping factors coupling the final stages of decay. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1c112ae6d5d7bf8d45dfca95f2570d
http://europepmc.org/articles/PMC6753473
http://europepmc.org/articles/PMC6753473
Autor:
Isioma I.I. Enwerem, Ai Lin, Nathan D. Elrod, Chung Te Chang, Yevgen Levdansky, Ping Ji, Jennifer A. Bohn, Aaron C. Goldstrohm, Eugene Valkov, Eric J. Wagner
Pumilio paralogs, PUM1 and PUM2, are sequence-specific RNA-binding proteins that are essential for vertebrate development and neurological functions. PUM1&2 negatively regulate gene expression by accelerating degradation of specific mRNAs. Here, we d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70e1f46f7f027a0871f9d4a5152b4d40
https://doi.org/10.1101/2020.11.17.387456
https://doi.org/10.1101/2020.11.17.387456
Autor:
Nathan D. Elrod, Aaron C. Goldstrohm, Eugene Valkov, Chung Te Chang, Yevgen Levdansky, Ai Lin, Ping Ji, Jennifer A. Bohn, Isioma I.I. Enwerem, Eric J. Wagner
Publikováno v:
RNA (New York, N.Y.). 27(4)
Pumilio paralogs, PUM1 and PUM2, are sequence-specific RNA-binding proteins that are essential for vertebrate development and neurological functions. PUM1&2 negatively regulate gene expression by accelerating degradation of specific mRNAs. Here, we d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f44046d374d0910fa5ae53c51141bcbb
https://pubmed.ncbi.nlm.nih.gov/33397688
https://pubmed.ncbi.nlm.nih.gov/33397688
Autor:
Aaron C. Goldstrohm, Yevgen Levdansky, Eugene Valkov, René M. Arvola, Chung Te Chang, Joseph P. Buytendorp, Peter L. Freddolino
Publikováno v:
Nucleic Acids Research
Pumilio is an RNA-binding protein that represses a network of mRNAs to control embryogenesis, stem cell fate, fertility, and neurological functions inDrosophila. We sought to identify the mechanism of Pumilio-mediated repression and find that it acce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba5d6d084781ffc12a842a5c0497b30c