An MITF- and mTOR-dependent FLCN pathway suppresses TFE3-driven metastasis in melanoma.

Autor: Chang J; Department of Surgery, College of Medicine, University of Iowa, Iowa City, IA, United States of America., Campbell-Hanson KR; Department of Surgery, College of Medicine, University of Iowa, Iowa City, IA, United States of America., Vanneste M; Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, IA, United States.; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA., Yevdash J; Department of Surgery, College of Medicine, University of Iowa, Iowa City, IA, United States of America., Bartschat NI; Department of Surgery, College of Medicine, University of Iowa, Iowa City, IA, United States of America., Jiang J; Department of Surgery, College of Medicine, University of Iowa, Iowa City, IA, United States of America., Bhinu A; Department of Surgery, College of Medicine, University of Iowa, Iowa City, IA, United States of America., Helverson A; Department of Surgery, College of Medicine, University of Iowa, Iowa City, IA, United States of America., Henry MD; Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, IA, United States.; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA., Steingrímsson E; Department of Biochemistry and Molecular Biology, BioMedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Weigel RJ; Department of Surgery, College of Medicine, University of Iowa, Iowa City, IA, United States of America.; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA., Cornell RA; Department of Oral Health Sciences, University of Washington, School of Dentistry, Seattle, WA, USA., Kenny C; Department of Surgery, College of Medicine, University of Iowa, Iowa City, IA, United States of America.; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jul 12. Date of Electronic Publication: 2024 Jul 12.