Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Yeung Y. Chan"'
Autor:
Zhiwei Guo, Animesh Goswami, Steven L. Goldberg, Kenneth J. Natalie, Vu Chi Truc, Chao Hang, Rossano Lucius T, Michael A. Schmidt, Andrew G. Lee, Ehrlic Lo, Yeung Y. Chan
Publikováno v:
Organic Process Research & Development. 19:1308-1316
The chiral β-hydroxy-α-amino acid, (2R,3S)-2-amino-3-hydroxy-3-(pyridin-4-yl)-propanoic acid, is a key intermediate in the synthesis of the API (2R,3S)-2-amino-3-hydroxy-3-(pyridin-4-yl)-1-(pyrrolidin-1-yl)propan-1-one, a developmental drug candida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb02e24fc17ba2492c2cb3e297aff494
https://doi.org/10.1021/acs.oprd.5b00191
https://doi.org/10.1021/acs.oprd.5b00191
Autor:
Richard Doyle, Robert M. Johnston, Wei Ding, Yeoun jin Kim, Changhong Wan, Yeung Y. Chan, Mian Gao, Olav Lyngberg, James William Bryson, Deepa Calambur, Mark R. Witmer, Stanley R. Krystek, Ronald L. Hanson, Ehrlic Lo, Steven H. Chan, Animesh Goswami, Nuria de Mas, Steven L. Goldberg, Antonio Ramirez
Publikováno v:
Bioconjugate chemistry. 27(5)
A disulfide-bridged peptide drug development candidate contained two oligopeptide chains with 11 and 12 natural amino acids joined by a disulfide bond at the N-terminal end. An efficient biotechnology based process for the production of the disulfide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f2c9a4bdec7035d8f9d6121167956d
https://pubmed.ncbi.nlm.nih.gov/27098672
https://pubmed.ncbi.nlm.nih.gov/27098672
Autor:
Derek Berglund, Jeffrey T. Bien, John Wasylak, Purushotham Vemishetti, David J. Kacsur, Jun Qiu, Oscar W. Haas, Chien-Kuang Chen, Yeung Y. Chan, Carrie A. Costello, Lori Spangler, Emily A. Reiff, Jale Muslehiddinoglu, Dale Vanyo, Stephane Gingras, Jaan A. Pesti, Nina Nguyen, Albert J. DelMonte, John A. Grosso, Chiajen Lai, Simon Leung, Wendel W. Doubleday, Michael J. Totleben, Paul Demena, Elisabeth Corbett, Martina Olzog, Dominique Thoraval, Serge Benoit, Melanie Miller, Robert P. Discordia, Zhinong Gao, Paul R. Brodfuehrer, Chenkou Wei
Publikováno v:
Organic Process Research & Development. 13:716-728
The development of a safe, robust process for the preparation of ravuconazole (1), an antifungal agent, is described. The discovery and development of procedures enabling the efficient synthesis of multikilogram quantities of 1 and the process demons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efd3df18d5b9bf645964394a96c66206
https://doi.org/10.1021/op900065c
https://doi.org/10.1021/op900065c
Autor:
Jack Z. Gougoutas, John C. Harris, and Donald L. Wedding, David A. Thurston, Gus A. Kodersha, David A. Lust, William Early, Dennis Ronald D, Daniel H. Kim, Atul S. Kotnis, Dominique Thoraval, William J. Winter, James L. Berg, Merrill L. Davies, Peter J. Bernot, James H. Simpson, Jerome L. Moniot, Neal G. Anderson, Paul A. Jass, Douglas W. Phillipson, Kai Tse, Droghini Roberto, Andrew Nguyen, Thomas D. Ary, Lajeunesse Jean, John D. Dimarco, Venkatapuram A. Palaniswamy, Hoang D. Do, Gary D. Madding, Oscar W. Haas, Yeung Y. Chan, Polomski Robert E, Rajan P. Deshpande, Chien-Kuang Chen, John A. Grosso, Sandeep P. Modi
Publikováno v:
Organic Process Research & Development. 1:300-310
5-Fluoro-3-[3-[4-(5-methoxy-4-pyrimidinyl)-1-piperazinyl]propyl]-1H-indole dihydrochloride (1) facilitates 5-HT neurotransmission and was an antidepressant drug candidate. The development of a safe, rugged process for the large-scale, chromatography-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e6663a3ce15b3152d0cb3b0548517d9
https://doi.org/10.1021/op970213h
https://doi.org/10.1021/op970213h
Autor:
Goswami A, Goldberg SL, Hanson RL, Johnston RM, Lyngberg OK, Chan Y, Lo E, Chan SH, de Mas N, Ramirez A, Doyle R, Ding W, Gao M; Discovery, R&D, Bristol-Myers Squibb , Route 206 and Province Line Road, Princeton, New Jersey 08543, United States., Krystek SR Jr; Discovery, R&D, Bristol-Myers Squibb , Route 206 and Province Line Road, Princeton, New Jersey 08543, United States., Wan C; Discovery, R&D, Bristol-Myers Squibb , Route 206 and Province Line Road, Princeton, New Jersey 08543, United States., Kim YJ; Discovery, R&D, Bristol-Myers Squibb , Route 206 and Province Line Road, Princeton, New Jersey 08543, United States., Calambur D; Discovery, R&D, Bristol-Myers Squibb , Route 206 and Province Line Road, Princeton, New Jersey 08543, United States., Witmer M; Discovery, R&D, Bristol-Myers Squibb , Route 206 and Province Line Road, Princeton, New Jersey 08543, United States., Bryson JW; Discovery, R&D, Bristol-Myers Squibb , Route 206 and Province Line Road, Princeton, New Jersey 08543, United States.
Publikováno v:
Bioconjugate chemistry [Bioconjug Chem] 2016 May 18; Vol. 27 (5), pp. 1276-84. Date of Electronic Publication: 2016 May 02.