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Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions.

Autor: Lam I; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Division of Movement Disorders, American Parkinson Disease Association (APDA) Center for Advanced Research and MSA Center of Excellence, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Ndayisaba A; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Division of Movement Disorders, American Parkinson Disease Association (APDA) Center for Advanced Research and MSA Center of Excellence, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Division of Neurobiology, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria., Lewis AJ; École Polytechnique Fédérale de Lausanne and University of Lausanne, Lausanne, Switzerland., Fu Y; The University of Sydney Brain and Mind Centre and Faculty of Medicine and Health School of Medical Science, Sydney, NSW, Australia., Sagredo GT; The University of Sydney Brain and Mind Centre and Faculty of Medicine and Health School of Medical Science, Sydney, NSW, Australia., Kuzkina A; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Division of Movement Disorders, American Parkinson Disease Association (APDA) Center for Advanced Research and MSA Center of Excellence, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Zaccagnini L; Dementia Research Institute, University College London, London, UK., Celikag M; Dementia Research Institute, University College London, London, UK., Sandoe J; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Sanz RL; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Division of Movement Disorders, American Parkinson Disease Association (APDA) Center for Advanced Research and MSA Center of Excellence, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Vahdatshoar A; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Division of Movement Disorders, American Parkinson Disease Association (APDA) Center for Advanced Research and MSA Center of Excellence, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Martin TD; Harvard Medical School, Boston, MA, USA; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Morshed N; Harvard Medical School, Boston, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA; Boston Children's Hospital, Boston, MA, USA; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ichihashi T; Nikon Corporation, Tokyo, Japan., Tripathi A; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Ramalingam N; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Oettgen-Suazo C; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Division of Movement Disorders, American Parkinson Disease Association (APDA) Center for Advanced Research and MSA Center of Excellence, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Bartels T; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Boussouf M; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Division of Movement Disorders, American Parkinson Disease Association (APDA) Center for Advanced Research and MSA Center of Excellence, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Schäbinger M; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Division of Movement Disorders, American Parkinson Disease Association (APDA) Center for Advanced Research and MSA Center of Excellence, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Hallacli E; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Division of Movement Disorders, American Parkinson Disease Association (APDA) Center for Advanced Research and MSA Center of Excellence, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Jiang X; Yumanity Therapeutics, Cambridge, MA, USA., Verma A; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Division of Movement Disorders, American Parkinson Disease Association (APDA) Center for Advanced Research and MSA Center of Excellence, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Tea C; University of California, San Diego, San Diego, CA, USA., Wang Z; University of California, San Diego, San Diego, CA, USA., Hakozaki H; University of California, San Diego, San Diego, CA, USA., Yu X; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Division of Movement Disorders, American Parkinson Disease Association (APDA) Center for Advanced Research and MSA Center of Excellence, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Hyles K; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Division of Movement Disorders, American Parkinson Disease Association (APDA) Center for Advanced Research and MSA Center of Excellence, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Park C; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Division of Movement Disorders, American Parkinson Disease Association (APDA) Center for Advanced Research and MSA Center of Excellence, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Wang X; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Division of Movement Disorders, American Parkinson Disease Association (APDA) Center for Advanced Research and MSA Center of Excellence, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Theunissen TW; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Wang H; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Jaenisch R; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Lindquist S; Whitehead Institute for Biomedical Research, Cambridge, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Stevens B; Harvard Medical School, Boston, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA; Boston Children's Hospital, Boston, MA, USA; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Stefanova N; Division of Neurobiology, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria., Wenning G; Division of Neurobiology, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria., van de Berg WDJ; Amsterdam University Medical Center, Vrije Universiteit, Amsterdam, the Netherlands., Luk KC; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Sanchez-Pernaute R; BioBizkaia Health Research Institute, Barakaldo, Spain; Ikerbasque, Basque Foundation for Science, Bilbao, Spain., Gómez-Esteban JC; BioBizkaia Health Research Institute, Barakaldo, Spain., Felsky D; Centre for Addiction and Mental Health, Toronto, ON, Canada; University of Toronto, Toronto, ON, Canada., Kiyota Y; Nikon Corporation, Tokyo, Japan., Sahni N; The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Baylor College of Medicine, Houston, TX, USA., Yi SS; The University of Texas at Austin, Austin, TX, USA., Chung CY; Yumanity Therapeutics, Cambridge, MA, USA., Stahlberg H; École Polytechnique Fédérale de Lausanne and University of Lausanne, Lausanne, Switzerland., Ferrer I; The University of Barcelona, Institut d'Investigacio Biomedica de Bellvitge IDIBELL, Hospitalet de Llobregat, Barcelona, Spain., Schöneberg J; University of California, San Diego, San Diego, CA, USA., Elledge SJ; Harvard Medical School, Boston, MA, USA; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Dettmer U; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Halliday GM; The University of Sydney Brain and Mind Centre and Faculty of Medicine and Health School of Medical Science, Sydney, NSW, Australia; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA., Bartels T; Dementia Research Institute, University College London, London, UK., Khurana V; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Division of Movement Disorders, American Parkinson Disease Association (APDA) Center for Advanced Research and MSA Center of Excellence, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; The Broad Institute of MIT and Harvard, Cambridge, MA, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA; Harvard Stem Cell Institute, Cambridge, MA, USA. Electronic address: khuranalab_admin@bwh.harvard.edu.

Publikováno v: Neuron [Neuron] 2024 Sep 04; Vol. 112 (17), pp. 2886-2909.e16. Date of Electronic Publication: 2024 Jul 29.

Automated algorithm development to assess survival of human neurons using longitudinal single-cell tracking: Application to synucleinopathy.

Autor: Choi J; Yumanity Therapeutics, 40 Guest St, Boston, MA, 02135, United States of America., Kii H; Nikon Corporation, Tokyo, Japan., Nelson J; Yumanity Therapeutics, 40 Guest St, Boston, MA, 02135, United States of America., Yamazaki Y; Nikon Corporation, Tokyo, Japan., Yanagawa F; Nikon Instruments, New York, United States of America., Kitajima A; Nikon Corporation, Tokyo, Japan., Uozumi T; Nikon Corporation, Tokyo, Japan., Kiyota Y; Nikon Corporation, Tokyo, Japan., Doshi D; Yumanity Therapeutics, 40 Guest St, Boston, MA, 02135, United States of America., Rhodes K; Yumanity Therapeutics, 40 Guest St, Boston, MA, 02135, United States of America., Scannevin R; Yumanity Therapeutics, 40 Guest St, Boston, MA, 02135, United States of America., Sadlish H; Yumanity Therapeutics, 40 Guest St, Boston, MA, 02135, United States of America., Chung CY; Yumanity Therapeutics, 40 Guest St, Boston, MA, 02135, United States of America.

Publikováno v: SLAS technology [SLAS Technol] 2023 Apr; Vol. 28 (2), pp. 63-69. Date of Electronic Publication: 2022 Nov 29.

Targeting de novo lipid synthesis induces lipotoxicity and impairs DNA damage repair in glioblastoma mouse models.

Autor: Eyme KM; Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.; Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany., Sammarco A; Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.; Department of Comparative Biomedicine and Food Science, University of Padua, Padua, Italy.; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA., Jha R; Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA., Mnatsakanyan H; Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA., Pechdimaljian C; Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA., Carvalho L; Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.; Neuroscience Program, Harvard Medical School, Boston, MA 02115, USA., Neustadt R; Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA., Moses C; Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA., Alnasser A; Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA., Tardiff DF; Yumanity Therapeutics, Boston, MA 02139, USA., Su B; Department of Biological Chemistry, University of California, Los Angeles, CA 90095, USA.; UCLA Lipidomics Laboratory, University of California, Los Angeles, CA 90095, USA., Williams KJ; Department of Biological Chemistry, University of California, Los Angeles, CA 90095, USA.; UCLA Lipidomics Laboratory, University of California, Los Angeles, CA 90095, USA., Bensinger SJ; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA.; UCLA Lipidomics Laboratory, University of California, Los Angeles, CA 90095, USA., Chung CY; Yumanity Therapeutics, Boston, MA 02139, USA., Badr CE; Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.; Neuroscience Program, Harvard Medical School, Boston, MA 02115, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2023 Jan 18; Vol. 15 (679), pp. eabq6288. Date of Electronic Publication: 2023 Jan 18.

Real-time monitoring of work-at-height safety hazards in construction sites using drones and deep learning.

Autor: Shanti MZ; Department of Civil, Infrastructure and Environmental Engineering, Khalifa University of Science and Technology, Abu Dhabi 127788, United Arab Emirates., Cho CS; Department of Civil, Infrastructure and Environmental Engineering, Khalifa University of Science and Technology, Abu Dhabi 127788, United Arab Emirates. Electronic address: chung.cho@ku.ac.ae., de Soto BG; Department of Civil and Urban Engineering, S.M.A.R.T. Construction Research Group, Division of Engineering, New York University Abu Dhabi (NYUAD), Saadiyat Island, Abu Dhabi 129188, United Arab Emirates., Byon YJ; Department of Civil, Infrastructure and Environmental Engineering, Khalifa University of Science and Technology, Abu Dhabi 127788, United Arab Emirates., Yeun CY; Department of Electrical Engineering and Computer Science, Khalifa University of Science and Technology, Abu Dhabi 127788, United Arab Emirates., Kim TY; Department of Civil, Infrastructure and Environmental Engineering, Khalifa University of Science and Technology, Abu Dhabi 127788, United Arab Emirates.

Publikováno v: Journal of safety research [J Safety Res] 2022 Dec; Vol. 83, pp. 364-370. Date of Electronic Publication: 2022 Oct 01.