Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Yetrib, Hathout"'
Autor:
Nalaka Wijekoon, Lakmal Gonawala, Pyara Ratnayake, Roshan Liyanage, Dhammika Amaratunga, Yetrib Hathout, Harry W. M. Steinbusch, Ashwin Dalal, Eric P. Hoffman, K. Ranil D. de Silva
Publikováno v:
European Journal of Medical Research, Vol 29, Iss 1, Pp 1-16 (2024)
Abstract Background The phenotype of Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) patients is determined by the type of DMD gene variation, its location, effect on reading frame, and its size. The primary objective of this in
Externí odkaz:
https://doaj.org/article/c4163d83d1134daf81f028ae6456712e
Autor:
Rodrigue Houngue, Lamba Omar Sangaré, Tchilabalo Dilezitoko Alayi, Aissatou Dieng, Tristan Bitard-Feildel, Claire Boulogne, Christian Slomianny, Cynthia Menonve Atindehou, Lucie Ayi Fanou, Yetrib Hathout, Isabelle Callebaut, Stanislas Tomavo
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113601- (2024)
Summary: Apicomplexan parasites possess specialized secretory organelles called rhoptries, micronemes, and dense granules that play a vital role in host infection. In this study, we demonstrate that TgREMIND, a protein found in Toxoplasma gondii, is
Externí odkaz:
https://doaj.org/article/ca72b0316c844ce5889846885c57736c
Autor:
Nalaka Wijekoon, Lakmal Gonawala, Pyara Ratnayake, Darshana Sirisena, Harsha Gunasekara, Athula Dissanayake, Sunethra Senanayake, Ajantha Keshavaraj, Yetrib Hathout, Harry W.M. Steinbusch, Chandra Mohan, Ashwin Dalal, Eric Hoffman, K.Ranil D de Silva
Publikováno v:
IBRO Neuroscience Reports, Vol 14, Iss , Pp 146-153 (2023)
Background: In this article, the authors discuss how they utilized the genetic mutation data in Sri Lankan Duchenne muscular dystrophy (DMD), Spinal muscular atrophy (SMA), Spinocerebellar ataxia (SCA) and Huntington’s disease (HD) patients and com
Externí odkaz:
https://doaj.org/article/4ac8bd1ca053427ab5295e8573dda7c8
Autor:
Nalaka Wijekoon, Lakmal Gonawala, Pyara Ratnayake, Pulasthi Dissanayaka, Isuru Gunarathne, Dhammika Amaratunga, Roshan Liyanage, Sunethra Senanayaka, Saraji Wijesekara, Hemal H. Gunasekara, Kamala Vanarsa, Jessica Castillo, Yetrib Hathout, Ashwin Dalal, Harry W.M. Steinbusch, Eric Hoffman, Chandra Mohan, K. Ranil D. de Silva
Publikováno v:
Heliyon, Vol 9, Iss 8, Pp e18530- (2023)
Introduction: Documented Duchenne Muscular Dystrophy (DMD) biomarkers are confined to Caucasians and are poor indicators of cognitive difficulties and neuropsychological alterations. Materials and methods: This study correlates serum protein signatur
Externí odkaz:
https://doaj.org/article/ea7f989c48ed46f8ad872ba9e802e1d3
Autor:
Tchilabalo D. Alayi, Shefa M. Tawalbeh, Michael Ogundele, Holly R. Smith, Alison M. Samsel, Marissa L. Barbieri, Yetrib Hathout
Publikováno v:
ACS Omega, Vol 5, Iss 41, Pp 26504-26517 (2020)
Externí odkaz:
https://doaj.org/article/d2a0a8d0f6be44e3a637408f9b4ab28d
Autor:
Shefa M. Tawalbeh, Wilfredo Marin, Gabrielle A. Morgan, Utkarsh J. Dang, Yetrib Hathout, Lauren M. Pachman
Publikováno v:
BMC Rheumatology, Vol 4, Iss 1, Pp 1-15 (2020)
Abstract Background Blood accessible biomarkers to assess disease activity and their response to therapies in Juvenile Dermatomyositis (JDM) are urgently needed. This pilot study aims to identify serum protein biomarkers associated with clinical dise
Externí odkaz:
https://doaj.org/article/8adedddc628b4e898ac8d2a8cafc5b96
Autor:
Michael Ziemba, Molly Barkhouse, Kitipong Uaesoontrachoon, Mamta Giri, Yetrib Hathout, Utkarsh J Dang, Heather Gordish-Dressman, Kanneboyina Nagaraju, Eric P Hoffman
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0246507 (2021)
Duchenne muscular dystrophy is initiated by dystrophin deficiency, but downstream pathophysiological pathways such as membrane instability, NFĸB activation, mitochondrial dysfunction, and induction of TGFβ fibrosis pathways are thought to drive the
Externí odkaz:
https://doaj.org/article/ce5d6cb03d0e4faca8116cb2ca183f89
Autor:
Ming Hu, Huanjing Bi, Deana Moffat, Margaret Blystone, Lillian DeCostanza, Tchilabalo Alayi, Kaiming Ye, Yetrib Hathout, Sha Jin
Publikováno v:
Molecules, Vol 26, Iss 21, p 6740 (2021)
Tissue microenvironments are rich in signaling molecules. However, factors in the tissue matrix that can serve as tissue-specific cues for engineering pancreatic tissues have not been thoroughly identified. In this study, we performed a comprehensive
Externí odkaz:
https://doaj.org/article/3ae06441d80249eba04a7294ca187097
Autor:
Michael Ogundele, Jesslyn S. Zhang, Mansi V. Goswami, Marissa L. Barbieri, Utkarsh J. Dang, James S. Novak, Eric P. Hoffman, Kanneboyina Nagaraju, CINRG-DNHS Investigators, Yetrib Hathout
Publikováno v:
Life, Vol 11, Iss 8, p 827 (2021)
Duchenne muscular dystrophy (DMD) is a progressive muscle disease involving complex skeletal muscle pathogenesis. The pathogenesis is triggered by sarcolemma instability due to the lack of dystrophin protein expression, leading to Ca2+ influx, muscle
Externí odkaz:
https://doaj.org/article/0d7db1a96ab9452987e5b9bd0f04eab0
Autor:
James S. Novak, Marshall W. Hogarth, Jessica F. Boehler, Marie Nearing, Maria C. Vila, Raul Heredia, Alyson A. Fiorillo, Aiping Zhang, Yetrib Hathout, Eric P. Hoffman, Jyoti K. Jaiswal, Kanneboyina Nagaraju, Sebahattin Cirak, Terence A. Partridge
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Exon skipping is a strategy for the treatment of Duchenne muscular dystrophy, but has variable efficacy. Here, the authors show that dystrophin restoration occurs preferentially in areas of myofiber regeneration, where antisense oligonucleotides are
Externí odkaz:
https://doaj.org/article/2bba740be75c451786064cc88308d9ee