Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Yetis Gultekin"'
Autor:
Caroline R. Bartman, Daniel R. Weilandt, Yihui Shen, Won Dong Lee, Yujiao Han, Tara TeSlaa, Connor S. R. Jankowski, Laith Samarah, Noel R. Park, Victoria da Silva-Diz, Maya Aleksandrova, Yetis Gultekin, Argit Marishta, Lin Wang, Lifeng Yang, Asael Roichman, Vrushank Bhatt, Taijin Lan, Zhixian Hu, Xi Xing, Wenyun Lu, Shawn Davidson, Martin Wühr, Matthew G. Vander Heiden, Daniel Herranz, Jessie Yanxiang Guo, Yibin Kang, Joshua D. Rabinowitz
Publikováno v:
Nature
Nature, vol 614, iss 7947
Nature, vol 614, iss 7947
Tissues derive ATP from two pathways-glycolysis and the tricarboxylic acid (TCA) cycle coupled to the electrontransport chain. Most energy in mammals is produced via TCA metabolism1. In tumours, however, the absolute rates of these pathways remain un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24537985f0041d48ddf65a08c08ae8e3
https://europepmc.org/articles/PMC10288502/
https://europepmc.org/articles/PMC10288502/
Autor:
Sharanya Sivanand, Yetis Gultekin, Peter S. Winter, Sidney Y. Vermeulen, Konstantine Tchourine, Laura V. Danai, Brian T. Do, Kayla Crowder, Tenzin Kunchok, Allison N. Lau, Alicia M. Darnell, Satoru Morita, Dan G. Duda, Andrew Aguirre, Brian M. Wolpin, Caroline A. Lewis, Dennis Vitkup, Alex K. Shalek, Matthew G. Vander Heiden
Metastases arise from a subset of cancer cells that disseminate from the primary tumor; however, the factors that contribute to proliferation of cancer cells in a secondary site are incompletely understood. The ability of cancer cells to thrive in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35609d6038e328628d4549bfd6c98408
https://doi.org/10.1101/2022.08.17.504141
https://doi.org/10.1101/2022.08.17.504141
Autor:
Hermann Steller, Yetis Gultekin
Publikováno v:
Development (Cambridge, England). 146(6)
The self-renewal of intestinal stem cell is controlled by Wingless/Wnt-β catenin signaling both in Drosophila and mammals. Since Axin is a rate-limiting factor in Wingless signaling its regulation is essential. Iduna is an evolutionarily conserved u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b56ff58ba41885794bbbcdec02fc7b59
https://pubmed.ncbi.nlm.nih.gov/30796047
https://pubmed.ncbi.nlm.nih.gov/30796047
Novel NLRP3/cryopyrin mutations and pro-inflammatory cytokine profiles in Behçet's syndrome patients
Autor:
Yetis Gultekin, Elif Eren, Sahru Yuksel, Duygu Demiröz, Izzet Fresko, Ali Can Sahillioglu, Nesrin Özören, Gulen Hatemi, Cezmi A. Akdis
Behçet’s syndrome (BS) is a systemic inflammatory disorder with unknown etiology. Features of both innate and adaptive immunity have been claimed in the pathogenesis of BS. To test the possible dysregulation of the NLRP3/cryopyrin (Nod-like recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75d560ce30b5e8061c9e2f46bc863b0
http://doc.rero.ch/record/295582/files/dxt046.pdf
http://doc.rero.ch/record/295582/files/dxt046.pdf
Autor:
Emma L. Baar, Amanda W. Hutchins, Rachel P. Gaither, Yetis Gultekin, Dudley W. Lamming, Ömer H. Yilmaz, Pekka Katajisto, Maria M. Mihaylova, David M. Sabatini
Publikováno v:
Aging Cell
Wiley Blackwell
Wiley Blackwell
Rapamycin, an inhibitor of the mechanistic target of rapamycin (mTOR), robustly extends the lifespan of model organisms including mice. We recently found that chronic treatment with rapamycin not only inhibits mTOR complex 1 (mTORC1), the canonical t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2a1ab6d08eb04c64f60098fc5ce3d9
http://europepmc.org/articles/PMC4172536
http://europepmc.org/articles/PMC4172536
Autor:
Henrik Molina, Wei Min, Jingyi Chi, Yetis Gultekin, Yihui Shen, Tao Peng, Justine Fidelin, Timothy C. Wang, Shirony Nicholson Puthenveedu, Xiphias Ge Zhu, Konnor La, Can Ozlu, Howard C. Hang, Kıvanç Birsoy, Diana Klompstra
Publikováno v:
Molecular Cell. 74:45-58.e7
Summary Cells require a constant supply of fatty acids to survive and proliferate. Fatty acids incorporate into membrane and storage glycerolipids through a series of endoplasmic reticulum (ER) enzymes, but how these enzymes are regulated is not well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a59a5adfa93ce4a865b09dc7b436caa
https://doi.org/10.1016/j.molcel.2019.01.037
https://doi.org/10.1016/j.molcel.2019.01.037
MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors
Autor:
Timothy R. Peterson, Yetis Gultekin, Ömer H. Yilmaz, Jan E. Carette, Thijn R Brummelkamp, Kıvanç Birsoy, Catherine E Koch, Richard Possemato, Clary B. Clish, Walter W. Chen, Timothy C. Wang, Amanda W. Hutchins, David M. Sabatini
Publikováno v:
Nature genetics
There is increasing evidence that oncogenic transformation modifies the metabolic program of cells. A common alteration is the upregulation of glycolysis, and efforts to target glycolytic enzymes for anticancer therapy are under way. Here, we perform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f327ddd6d34efdafd532e2483a9bab4d
http://europepmc.org/articles/PMC3530647
http://europepmc.org/articles/PMC3530647
Autor:
Kıvanç Birsoy, Vikram Deshpande, Ömer H. Yilmaz, Pekka Katajisto, Yetis Gultekin, Atul K. Bhan, G. Petur Nielsen, David M. Sabatini, Dudley W. Lamming, Khristian E. Bauer-Rowe, Martin K. Selig, Shomit Sengupta, Lawrence R. Zukerberg, Abdulmetin Dursun, V. Onur Yilmaz, Mari Mino-Kenudson
Publikováno v:
Nature
How adult tissue stem and niche cells respond to the nutritional state of an organism is not well understood. Here we find that Paneth cells, a key constituent of the mammalian intestinal stem-cell (ISC) niche, augment stem-cell function in response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec3bb4bf382c3706bb75e0402cb9b98
http://europepmc.org/articles/PMC3387287
http://europepmc.org/articles/PMC3387287
Autor:
Izzet Fresko, A. Otsuka, Kou Motani, E. Kuroda, H. Wake, T. Maruo, Hiroko Kushiyama, Antonella Galvan, M. Nishibori, José Ricardo Jensen, Michel Seman, W.H. Cabrera, Patrícia dos Santos Carneiro, Sahru Yuksel, Francisca Vorraro, S. Taniguchi, H. Shimosato-Asano, Elif Eren, Ryu Imamura, M. De Franco, Nancy Starobinas, Yetis Gultekin, Shigeo Mori, Hiroki Takahashi, Y. Morimoto, L. E. Jensen, K. Liu, Y. Tomono, Gulen Hatemi, Olga M. Ibañez, T. Matsumura, Orlando Garcia Ribeiro, H. Yazıcı, Nesrin Özören, Jiyong Zhang, N. Araki, Takeshi Kinoshita, Tommaso A. Dragani, D. Demiröz, Toshio Suda, G. E. Pérez Figueroa, M. Cifdaloz
Publikováno v:
International Immunology. 22:iv84-iv86
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69b66bc78d1d6c90473f9f78f812e14a
https://doi.org/10.1093/intimm/dxq258
https://doi.org/10.1093/intimm/dxq258
Publikováno v:
Journal of innate immunity. 7(1)
The novel nucleotide oligomerization domain (NOD)-like receptor (NLR) with a caspase activation and recruitment domain (CARD) 3 (NLRC3) protein belongs to the NLR family of cytosolic pathogen recognition receptors. NLRC3 has the characteristic NOD an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88f68a89269d14eada88f03e9d522ede
https://pubmed.ncbi.nlm.nih.gov/25277106
https://pubmed.ncbi.nlm.nih.gov/25277106