Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Yesim A, Tahirovic"'
Autor:
Michael C. Regan, Zongjian Zhu, Hongjie Yuan, Scott J. Myers, Dave S. Menaldino, Yesim A. Tahirovic, Dennis C. Liotta, Stephen F. Traynelis, Hiro Furukawa
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Context-dependent inhibition of NMDA receptors has important therapeutic implications for treatment of neurological diseases. Here, the authors use structural biology and biophysics to describe the basis for pH-dependent inhibition for a class of all
Externí odkaz:
https://doaj.org/article/6b226358d0264cea8bca51d4ed185d0d
Autor:
Lynnea D. Harris, Michael C. Regan, Scott J. Myers, Kelsey A. Nocilla, Nicholas S. Akins, Yesim A. Tahirovic, Lawrence J. Wilson, Ray Dingledine, Hiro Furukawa, Stephen F. Traynelis, Dennis C. Liotta
Publikováno v:
ACS Chemical Neuroscience. 14:917-935
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12f338a85c3f3e0624b576a9e746af74
https://doi.org/10.1021/acschemneuro.2c00779
https://doi.org/10.1021/acschemneuro.2c00779
Autor:
Riley Perszyk, Brooke M Katzman, Hirofumi Kusumoto, Steven A Kell, Matthew P Epplin, Yesim A Tahirovic, Rhonda L Moore, David Menaldino, Pieter Burger, Dennis C Liotta, Stephen F Traynelis
Publikováno v:
eLife, Vol 7 (2018)
N-methyl-d-aspartate receptors (NMDARs) are an important receptor in the brain and have been implicated in multiple neurological disorders. Many non-selective NMDAR-targeting drugs are poorly tolerated, leading to efforts to target NMDAR subtypes to
Externí odkaz:
https://doaj.org/article/ebbc00f7f3b642f9a1fc75a7e8319d7c
Autor:
George W. Koszalka, Kamalesh P. Ruppa, Polina Lyuboslavsky, David S. Menaldino, Raymond Dingledine, Dennis C. Liotta, Stephen F. Traynelis, Zackery W. Dentmon, Lawrence J. Wilson, Scott J. Myers, Robert Zaczek, Yesim Altas Tahirovic
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 379:41-52
We describe a clinical candidate molecule from a new series of glutamate N-methyl-d-aspartate receptor subunit 2B-selective inhibitors that shows enhanced inhibition at extracellular acidic pH values relative to physiologic pH. This property should r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0c1e8e93e3ee0c58291395f09218349
https://doi.org/10.1124/jpet.120.000370
https://doi.org/10.1124/jpet.120.000370
Autor:
Edgars Jecs, Yesim A. Tahirovic, Robert J. Wilson, Eric J. Miller, Michelle Kim, Valarie Truax, Huy H. Nguyen, Nicholas S. Akins, Manohar Saindane, Tao Wang, Chi S. Sum, Mary E. Cvijic, Gretchen M. Schroeder, Samantha L. Burton, Cynthia A. Derdeyn, Lingjie Xu, Yi Jiang, Lawrence J. Wilson, Dennis C. Liotta
Publikováno v:
Journal of medicinal chemistry. 65(5)
Our first-generation CXCR4 antagonist TIQ15 was rationally modified to improve drug-like properties. Introducing a nitrogen atom into the aromatic portion of the tetrahydroisoquinoline ring led to several heterocyclic variants including the 5,6,7,8-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b393ed15a5b53abcfd5ac6f12274c8e4
https://pubmed.ncbi.nlm.nih.gov/35179893
https://pubmed.ncbi.nlm.nih.gov/35179893
Autor:
Chi S. Sum, Yi Jiang, Yesim Altas Tahirovic, Lingjie Xu, Dennis C. Liotta, Michelle B. Kim, Nicholas S. Akins, Lawrence J. Wilson, Huy Nguyen, Mary Ellen Cvijic, Gretchen M. Schroeder, Tao Wang, Valarie M. Truax, Robert Wilson, Eric J. Miller, Edgars Jecs
Publikováno v:
ACS Med Chem Lett
[Image: see text] This work surveys a variety of diamino-heterocycles as an isosteric replacement for the piperazine substructure of our previously disclosed piperarinyl-tetrahydroisoquinoline containing CXCR4 antagonists. A late-stage Buchwald coupl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd15efbdf4f13c7f5fae15f6ab98bdb6
https://europepmc.org/articles/PMC8521655/
https://europepmc.org/articles/PMC8521655/
Autor:
Eric J. Miller, Carrie Q. Sun, Petra Gregorova, Edgars Jecs, Yesim Altas Tahirovic, Robert J. Wilson, Huy H. Nguyen, Savita K. Sharma, Perry Bartsch, Zachary Sticher, Levi Moellering, Priscilla Davidson, Ryan Jajosky, Michael D'Erasmo, Manohar Saindane, Zafer Sahin, Nicholas S. Akins, Alexander A. Kolykhalov, Lawrence Wilson, Rebecca S. Arnold, John A. Petros, Haydn Kissick, Lingjie Xu, Yi Jiang, Dennis C. Liotta
Publikováno v:
Cancer Research. 82:2649-2649
Purpose: Pro-angiogenic and immune cells expressing chemokine receptor CXCR4 traffic along concentration gradients of the chemokine ligand CXCL12, which disseminates from stromal niches. The CXCR4/CXCL12 axis is hijacked by various cancer types chara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d27eabc5a921f9e628cb90e2d983ea4
https://doi.org/10.1158/1538-7445.am2022-2649
https://doi.org/10.1158/1538-7445.am2022-2649
Autor:
Scott J, Myers, Kamalesh P, Ruppa, Lawrence J, Wilson, Yesim A, Tahirovic, Polina, Lyuboslavsky, David S, Menaldino, Zackery W, Dentmon, George W, Koszalka, Robert, Zaczek, Raymond J, Dingledine, Stephen F, Traynelis, Dennis C, Liotta
Publikováno v:
J Pharmacol Exp Ther
We describe a clinical candidate molecule from a new series of glutamate N-methyl-d-aspartate receptor subunit 2B–selective inhibitors that shows enhanced inhibition at extracellular acidic pH values relative to physiologic pH. This property should
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::db965d485c48ecef3089d635d22d3940
https://pubmed.ncbi.nlm.nih.gov/34493631
https://pubmed.ncbi.nlm.nih.gov/34493631
Autor:
Edgars Jecs, Savita Sharma, Yesim Altas Tahirovic, Dennis C. Liotta, Sameshnee Pelly, Lawrence J. Wilson, Eric J. Miller
Publikováno v:
Expert opinion on therapeutic patents. 30(2)
Introduction: The chemokine receptor CXCR4 has been under intense study due to the central role it plays in immune system regulation and the pathology of many human diseases. The FDA approval of the first CXCR4 antagonist drug Plerixafor (i.e. AMD310
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d582df6a81801f39fd69e4f26b0955bc
https://pubmed.ncbi.nlm.nih.gov/31854208
https://pubmed.ncbi.nlm.nih.gov/31854208
Autor:
Chi S. Sum, Christopher J. Butch, Lawrence J. Wilson, Katie M. Kuo, Michelle B. Kim, Yesim Altas Tahirovic, Mary Ellen Cvijic, Huy Nguyen, Dennis C. Liotta, Tao Wang, Robert Wilson, Valarie M. Truax, Eric J. Miller, Gretchen M. Schroeder, Edgars Jecs
Publikováno v:
Journal of Medicinal Chemistry. 61:7168-7188
CXCR4 is a G-protein-coupled receptor that interacts with its cognate ligand, CXCL12, to synchronize many physiological responses and pathological processes. Disruption of the CXCL12-CXCR4 circuitry by small-molecule antagonists has emerged as a prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79aa355fc7e64b8be28843fa21520a33
https://doi.org/10.1021/acs.jmedchem.8b00450
https://doi.org/10.1021/acs.jmedchem.8b00450