Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Yesim, Tuncay"'
Autor:
Vinay S. Mahajan, Hamid Mattoo, Na Sun, Vinayak Viswanadham, Grace J. Yuen, Hugues Allard-Chamard, Maimuna Ahmad, Samuel J. H. Murphy, Annaiah Cariappa, Yesim Tuncay, Shiv Pillai
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
B cell progenitors differentiate into multiple subsets with distinct functions. Here the authors analyze the epigenetic landscapes of sorted B cell subsets using multiple platforms and show that the epigenetic regulator, DNMT3A, is essential for modu
Externí odkaz:
https://doaj.org/article/3f5d4b4a728a40e5ad631b0536b74c49
Autor:
Shiv Pillai, Samuel J.H. Murphy, Vinay Mahajan, Hugues Allard-Chamard, Na Sun, Grace J. Yuen, Hamid Mattoo, Annaiah Cariappa, Vinayak Viswanadham, Maimuna Ahmad, Yesim Tuncay
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
The B1 and B2 lineages of B cells contribute to protection from pathogens in distinct ways. The role of the DNA CpG methylome in specifying these two B-cell fates is still unclear. Here we profile the CpG modifications and transcriptomes of peritonea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0eee239ff6bbfae29faa7deb0e91b9c
https://doaj.org/article/3f5d4b4a728a40e5ad631b0536b74c49
https://doaj.org/article/3f5d4b4a728a40e5ad631b0536b74c49
Autor:
Yesim Tuncay, Liam Harvey, Akira Tinju, Vinay Mahajan, Hugues Allard-Chamard, Samuel J.H. Murphy, Cory A. Perugino, Jesper Kers, Takashi Maehara, Seiji Nakamura, Ryusuke Munemura, Xiuwei Zhang, Emanuel Della-Torre, Mizuki Sakamoto, Hang Liu, Sydney B. Montesi, Zachary S. Wallace, Musie Ghebremichael, Lloyd L. Liang, Keita Mochizuki, John H. Stone, Geetha H. Mylvaganam, Masafumi Moriyama, Shiv Pillai, Nir Yosef, Naoki Kaneko, Hamid Mattoo, Marcy B. Bolster
Publikováno v:
Journal of Allergy and Clinical Immunology, 147(1), 368-382. MOSBY-ELSEVIER
Journal of allergy and clinical immunology, 147(1), 368-382. Mosby Inc.
Journal of allergy and clinical immunology, 147(1), 368-382. Mosby Inc.
Background: IgG(4)-related disease (IgG(4)-RD) is an immune-mediated fibrotic disorder that has been linked to CD4(+) cytotoxic T lymphocytes (CD4(+)CTLs). The effector phenotype of CD4(+)CTLs and the relevance of both CD8(+) cytotoxic T lymphocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80ef7590afa08540796322d5278b038c
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704943
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704943
Autor:
Takashi Maehara, Cory Perugino, Naoki Kaneko, Hamid Mattoo, Jesper Kers, Hugues Allard- Chamard, Vinay Mahajan, Hang Liu, Samuel Murphy, Musie Ghebremichael, Yesim Tuncay, DELLA TORRE E, Lloyd Liang, Sydney Montesi, Zachary Wallace, David Fox, Robert Lafyatis, John Stone, Dinesh Khanna and Shiv Pillai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_____10495::6fde38f2e8f5b89acf3398897a52045e
Autor:
Cory Perugino, Naoki Kaneko, Jesper Kers, Takashi Maehara, Hamid Mattoo, Hang Liu, Vinay Mahajan, Musie Ghebremichael, Hugues Allard-Chamard, Yesim Tuncay, DELLA TORRE E, Zachary Wallace, Lloyd Liang, Sydney Montesi, John Stone and Shiv Pillai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_____10495::0c79bb80e01541e791601c8a64155d13
Autor:
Hugues Allard-Chamard, Na Sun, Samuel J.H. Murphy, Vinay Mahajan, Yesim Tuncay, Maimuna Ahmad, Shiv Pillai, Vinayak Viswanadham, Cariappa Annaiah, Hamid Mattoo, Grace J. Yuen
We show that DNA methylation is a layered process in B lymphocytes. An underlying foundational methylome is stably established during B lineage commitment and overlaid with a DNMT3A-maintained dynamic methylome which is sculpted in distinct ways in B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c69b5ef2679ec31e6f52a552542c4afb
Autor:
Cory A, Perugino, Naoki, Kaneko, Takashi, Maehara, Hamid, Mattoo, Jesper, Kers, Hugues, Allard-Chamard, Vinay S, Mahajan, Hang, Liu, Emanuel, Della-Torre, Samuel J H, Murphy, Musie, Ghebremichael, Zachary S, Wallace, Marcy B, Bolster, Liam M, Harvey, Geetha, Mylvaganam, Yesim, Tuncay, Lloyd, Liang, Sydney B, Montesi, Xiuwei, Zhang, Akira, Tinju, Keita, Mochizuki, Ryusuke, Munemura, Mizuki, Sakamoto, Masafumi, Moriyama, Seiji, Nakamura, Nir, Yosef, John H, Stone, Shiv, Pillai
Publikováno v:
J Allergy Clin Immunol
BACKGROUND: IgG4-related disease (IgG4-RD) is an immune-mediated fibrotic disorder that has been linked to CD4+ cytotoxic T lymphocytes (CD4+CTLs). The effector phenotype of CD4+CTLs, the relevance of both CD8+ cytotoxic T lymphocytes (CD8+CTLs) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b9e1f28e09ed507ee5658a917ac0250b
https://pubmed.ncbi.nlm.nih.gov/32485263
https://pubmed.ncbi.nlm.nih.gov/32485263
Autor:
Rachel Peters, Kate Lizotte, Victoria Frank, Yesim Tuncay, Katie Sellers, Elia Aguado-Fraile, Marc L. Hyer, Everton Mandley, Scott A. Biller, Michelle Clasquin, Katya Marjon, Phong Quang, Jeremy Travins, Joshua E. Goldford, Zenon D. Konteatis, Chi-Chao Chen, Jaclyn Weier, Lenny Dang, Raj Nagaraja, Peter Kalev, Kevin Marks, Wei Liu, Eric Simone, Joshua Murtie, Stefan Gross, Max Lein, Yue Chen, Mark Fletcher, Amelia Barnett, Zhihua Sui, Sebastian Hayes
Publikováno v:
Cancer Cell. 39:209-224.e11
The methylthioadenosine phosphorylase (MTAP) gene is located adjacent to the cyclin-dependent kinase inhibitor 2A (CDKN2A) tumor-suppressor gene and is co-deleted with CDKN2A in approximately 15% of all cancers. This co-deletion leads to aggressive t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0321c4d9d9fb5c7eb5dbd4d4870244aa
https://doi.org/10.1016/j.ccell.2020.12.010
https://doi.org/10.1016/j.ccell.2020.12.010
Autor:
Elia Aguado-Fraile, Sheila Newhouse, Mark Fletcher, Chi-Chao Chen, Marc L. Hyer, Katya Marjon, Raj Nagaraja, Max Lein, Yesim Tuncay, Josh Murtie, Everton Mandley, Kevin Marks, Peter Kalev
Publikováno v:
Cancer Research. 80:3090-3090
MAT2A (methionine adenosyltransferase 2 alpha) is a critical enzyme within the methionine salvage pathway responsible for generating the universal methyl group donor, S-adenosyl methionine (SAM). We have developed a first-in-class small molecule inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8677b9f70676367f07acf17c0751d197
https://doi.org/10.1158/1538-7445.am2020-3090
https://doi.org/10.1158/1538-7445.am2020-3090
Autor:
Kevin Marks, Peili Zhang, Katya Marjon, Zenon D. Konteatis, Yesim Tuncay, Mark Fletcher, Marc L. Hyer, Everton Mandley, Jeremy Travins, Peter Kalev, Elia Aguado-Fraile
Publikováno v:
Molecular Cancer Therapeutics. 18:B115-B115
Methylthioadenosine phosphorylase (MTAP) is the enzyme in the methionine salvage pathway that metabolizes the byproduct of polyamine biosynthesis, 5′-methylthioadenosine (MTA). The MTAP gene is deleted in approximately 15% of all human cancers and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c85c390cce55ab0a34b59664e023da4c
https://doi.org/10.1158/1535-7163.targ-19-b115
https://doi.org/10.1158/1535-7163.targ-19-b115