Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Yeshuang Yuan"'
Autor:
Bo Zhang, Jiaqi Sun, Yeshuang Yuan, Dezhong Ji, Yeting Sun, Yudong Liu, Shengjie Li, Xingxing Zhu, Xunyao Wu, Jin Hu, Qiu Xie, Ling Wu, Lulu Liu, Boyang Cheng, Yuanjie Zhang, Lingjuan Jiang, Lidan Zhao, Fei Yu, Wei Song, Min Wang, Yue Xu, Shiliang Ma, Yunyun Fei, Lihe Zhang, Demin Zhou, Xuan Zhang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-18 (2023)
Abstract Interleukin-2 (IL-2) is a pleiotropic cytokine that orchestrates bidirectional immune responses via regulatory T cells (Tregs) and effector cells, leading to paradoxical consequences. Here, we report a strategy that exploited genetic code ex
Externí odkaz:
https://doaj.org/article/54b67c247f09488da75d1bf81a523a7c
Publikováno v:
ACS Omega, Vol 6, Iss 11, Pp 7931-7940 (2021)
Externí odkaz:
https://doaj.org/article/3f83bdc804964985a7f4c945b8412c05
Publikováno v:
Biochemistry and Biophysics Reports, Vol 28, Iss , Pp 101112- (2021)
The widespread application of protein and peptide therapeutics is hampered by their poor stability, strong immunogenicity and short half-life. However, the existing protein modification technologies require the introduction of exogenous macromolecule
Externí odkaz:
https://doaj.org/article/998fe78a8fee4fe9a8a5347ab9eb4020
Autor:
Jin Hu, Jianquan Shi, Yeshuang Yuan, Shengjie Li, Bo Zhang, Haitao Dong, Qing Zhong, Qiu Xie, Xiaoyin Bai, Yingxing Li
Publikováno v:
RSC Advances. 12:28279-28282
An easy but universal protein modification approach, self-fused concatenation (SEC), to biosynthesize a set of interferon concatemers with improved pharmaceutical profiles.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb779bdc81a85035cf846e0906a803f0
https://doi.org/10.1039/d2ra04978c
https://doi.org/10.1039/d2ra04978c
Publikováno v:
Turkish Journal of Medical Sciences. 52:984-989
To measure the expression of 1α-hydroxylase (CYP27B1) and serum 25(OH)D concentration in systemic lupus erythematosus (SLE) and to investigate the role of CYP27B1 in SLE.Seventy-seven SLE patients and 35 healthy controls (HCs) were enrolled from Sep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed123fdbaadf8004e29a54020f89f67
https://doi.org/10.55730/1300-0144.5399
https://doi.org/10.55730/1300-0144.5399
Autor:
Yeshuang Yuan, Antonios G.A. Kolios, Yudong Liu, Bo Zhang, Hao Li, George C. Tsokos, Xuan Zhang
Autoimmune diseases are characterized by dysregulation and aberrant activation of cells in the immune system. Therefore, restoration of the immune balance represents a promising therapeutic target in autoimmune diseases. Interleukin-2 (IL-2) can prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc8ab7c01cb1de897327f8f48ca12f1
https://doi.org/10.5167/uzh-227496
https://doi.org/10.5167/uzh-227496
Publikováno v:
Biochemistry and Biophysics Reports, Vol 28, Iss, Pp 101112-(2021)
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports
The widespread application of protein and peptide therapeutics is hampered by their poor stability, strong immunogenicity and short half-life. However, the existing protein modification technologies require the introduction of exogenous macromolecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ed5f9b46a29cc3c141411c89910b62
http://www.sciencedirect.com/science/article/pii/S2405580821002077
http://www.sciencedirect.com/science/article/pii/S2405580821002077
Publikováno v:
ACS Omega
ACS Omega, Vol 6, Iss 11, Pp 7931-7940 (2021)
ACS Omega, Vol 6, Iss 11, Pp 7931-7940 (2021)
Therapeutic proteins such as enzymes, hormones, and cytokines suffer from poor stability, inefficient cellular penetration, and rapid clearance from circulation. Conjugation with polymers (such as poly(ethylene glycol)) and fusion with long-acting pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b9e680cfcd5ab7f13e6e1c030781a2
https://pubmed.ncbi.nlm.nih.gov/33778304
https://pubmed.ncbi.nlm.nih.gov/33778304
Autor:
Wenxiao Ma, Lihe Zhang, Yan Wang, Min Wang, Xuan Zhang, Yingqin Hou, Dezhong Ji, George C. Tsokos, Jiaqi Sun, Lidan Zhao, Ling Wu, Pengchong Li, Hao Li, Bo Zhang, Yeshuang Yuan, Yeting Sun, Demin Zhou, Fei Yu, Xiaogang Li, Boyang Cheng, Jin Hu, Hua Chen, Wei Song, Yunyun Fei, Shengjie Li
Publikováno v:
Nature biomedical engineering. 5(11)
The preferential activation of regulatory T (Treg) cells by interleukin-2 (IL-2), which selectively binds to the trimeric IL-2 receptor (IL-2R) on Treg cells, makes this cytokine a promising therapeutic for the treatment of autoimmune diseases. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26895c1b2ba2add7a2cef45d8f51793e
https://pubmed.ncbi.nlm.nih.gov/34580438
https://pubmed.ncbi.nlm.nih.gov/34580438
Autor:
Bo Zhang, Yan Wang, Yeshuang Yuan, Jiaqi Sun, Lulu Liu, Dan Huang, Jin Hu, Min Wang, Shengjie Li, Wei Song, Hua Chen, Demin Zhou, Xuan Zhang, Zhang, Bo, Wang, Yan, Yuan, Yeshuang, Sun, Jiaqi, Liu, Lulu, Huang, Dan, Hu, Jin
Publikováno v:
Annals of the Rheumatic Diseases; Feb2021, Vol. 80 Issue 2, p176-184, 9p