Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Yepeng Luan"'
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
Background: Maintenance therapy with the poly (ADP-ribose) polymerase inhibitors (PARPis) for platinum-sensitive recurrent ovarian carcinoma (OC) have proven to be effective compared with placebo. We aimed to evaluate the cost-effectiveness (CE) of m
Externí odkaz:
https://doaj.org/article/7f73ac6e11cb4f1ebdca8d4fed02fadf
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49366 (2012)
Drug distribution in cells is a fundamentally important, yet often overlooked, variable in drug efficacy. Many weakly basic anticancer agents accumulate extensively in the acidic lysosomes of normal cells through ion trapping. Lysosomal trapping redu
Externí odkaz:
https://doaj.org/article/ff8f6756132541a2b8c9f313906f7f9c
Publikováno v:
Current Medicinal Chemistry. 30:2267-2311
Abstract: Inhibition of histone deacetylases (HDACs) has proven to be an effective strat-egy for cancer therapy. To date, five histone deacetylase inhibitors (HDACis) have been approved for cancer treatment, and numerous others are undergoing clinica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49bb1cae609e7019b20dc231a91ec751
https://doi.org/10.2174/0929867329666220826163626
https://doi.org/10.2174/0929867329666220826163626
Publikováno v:
Drug Discoveries & Therapeutics. 16:286-292
Gemcitabine is widely used in the clinic as a first-line antitumor agent. However, intrinsic and acquired resistance hinders its wide clinical application. In this study, a gemcitabine prodrug nominated as WRQ-2 was designed and synthesized by conjug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63076fbfc9d408bf804210e38914138
https://doi.org/10.5582/ddt.2022.01077
https://doi.org/10.5582/ddt.2022.01077
Autor:
Xuling Chen, Anqi Huang, Hanhui Zhao, Shuai Liang, Fushuai Li, Yepeng Luan, Pengfei Li, Wenjun Li
Publikováno v:
Organic Chemistry Frontiers. 8:1243-1248
The chiral phosphoric acid catalyzed regio-, diastereo- and enantioselective reaction of isoxazol-5(4H)-ones with β,γ-alkynyl-α-imino esters has been developed. With the established methodology, γ-addition of β,γ-alkynyl-α-imino esters and C-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50a7d9811b476446e2c920818ecc21a0
https://doi.org/10.1039/d0qo01505a
https://doi.org/10.1039/d0qo01505a
Publikováno v:
Bioorganicmedicinal chemistry letters. 72
Gemcitabine, as a first-line antitumor drug, has attracted extensive attention. However the occurrence of drug resistance limits its clinical utilization. In this paper, a gemcitabine prodrug GZ was designed and synthesized by conjugation of gemcitab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a347c6c279f2fb5a48879bc00775f6d
https://pubmed.ncbi.nlm.nih.gov/35810950
https://pubmed.ncbi.nlm.nih.gov/35810950
Publikováno v:
Current Medicinal Chemistry. 27:5562-5582
Gemcitabine as a pyrimidine nucleoside analog anticancer drug has high efficacy for a broad spectrum of solid tumors. Gemcitabine is activated within tumor cells by sequential phosphorylation carried out by deoxycytidine kinase to mono-, di-, and tri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0fe5ed7674a6ab1c50343ada908a68a
https://doi.org/10.2174/0929867326666190816230650
https://doi.org/10.2174/0929867326666190816230650
Publikováno v:
Advanced Synthesis & Catalysis. 362:1286-1291
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75f6c31ddcc6445067232c7a5ab65ac8
https://doi.org/10.1002/adsc.201901608
https://doi.org/10.1002/adsc.201901608
Publikováno v:
Letters in Drug Design & Discovery. 17:57-67
Background: Cancer incidence and mortality have been increasing and cancer is still the leading cause of death all over the world. Despite the enormous progress in cancer treatment, many patients died of ineffective chemotherapy and drug resistance.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edf63b2b3cadd79933dabbe36f8c3578
https://doi.org/10.2174/1570180816666181115112236
https://doi.org/10.2174/1570180816666181115112236