CPNE7-Induced Autophagy Restores the Physiological Function of Mature Odontoblasts

Autor: Yeoung-Hyun Park, Chul Son, You-Mi Seo, Yoon Seon Lee, Alix Har, Joo-Cheol Park

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Dentin, which composes most of the tooth structure, is formed by odontoblasts, long-lived post-mitotic cells maintained throughout the entire life of the tooth. In mature odontoblasts, however, cellular activity is significantly weakened. Therefore,

Externí odkaz: https://doaj.org/article/a286688cdde2478b8343ca49eb78dec3

Tubular Dentin Regeneration Using a CPNE7-Derived Functional Peptide

Autor: Yoon Seon Lee, Yeoung-Hyun Park, Dong-Seol Lee, You-Mi Seo, Ji-Hyun Lee, Joo-Hwang Park, Han-Wool Choung, So-Hyun Park, Won Jun Shon, Joo-Cheol Park

Publikováno v: Materials, Vol 13, Iss 20, p 4618 (2020)

We aim to examine the effects of a newly developed peptide derived from CPNE7 (Cpne7-DP) in tertiary dentin formation and peritubular space occlusion, and comprehensively evaluate its potential as a bioactive therapeutic agent. Human dental pulp cell

Externí odkaz: https://doaj.org/article/0fe3176069b8410b9157305cce1de2aa

Tubular dentin formation by TGF‐β/BMP signaling in dental epithelial cells

Autor: Yoon Seon Lee, Yeoung‐Hyun Park, You‐Mi Seo, Hye‐Kyung Lee, Joo‐Cheol Park

Publikováno v: Oral Diseases. 29:1644-1656

This study aimed to identify formation of tubular dentin induced by transforming growth factor-β (TGF-β) and bone morphogenic protein (BMP) signaling pathway in dental epithelial cells.We collected conditioned medium (CM) of rTGF-β1/rBMP-2-treated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2446fe0891f5b8c028fa88b0de38e42d
https://doi.org/10.1111/odi.14170

3D Visualization of Dynamic Cellular Reaction of Pulpal CD11c+ Dendritic Cells against Pulpitis in Whole Murine Tooth

Autor: Pilhan Kim, Jehwi Jeon, Yeoung-Hyun Park, Hyung-Ryong Kim, Jingu Lee, Su-Jung Hong, Eunji Kong, Jieun Moon, Joo-Cheol Park

Publikováno v: International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12683
International Journal of Molecular Sciences, Vol 22, Iss 12683, p 12683 (2021)
International Journal of Molecular Sciences

In dental pulp, diverse types of cells mediate the dental pulp immunity in a highly complex and dynamic manner. Yet, 3D spatiotemporal changes of various pulpal immune cells dynamically reacting against foreign pathogens during immune response have n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9abc9aecf3bd5f3932bab9a5f3c133

Expression of CPNE7 during mouse dentinogenesis

Autor: Seung-Hee Kim, Hyun Sook Bae, Yoon Seon Lee, Yeoung-Hyun Park, Jung-Su Park, Joo-Cheol Park

Publikováno v: Journal of Molecular Histology. 50:179-188

Interactions between the ectodermal and mesenchymal tissues are the basis of the central mechanism regulating tooth development. Based on this epithelial-mesenchymal interaction (EMI), we demonstrated that copine-7 (CPNE7) is secreted by preameloblas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e286a8ef3496d1431e407ed9228818
https://doi.org/10.1007/s10735-019-09816-0