The therapeutically actionable long non-coding RNA ‘T-RECS’ is essential to cancer cells’ survival in NRAS/MAPK-driven melanoma

Autor: Valentin Feichtenschlager, Linan Chen, Yixuan James Zheng, Wilson Ho, Martina Sanlorenzo, Igor Vujic, Eleanor Fewings, Albert Lee, Christopher Chen, Ciara Callanan, Kevin Lin, Tiange Qu, Dasha Hohlova, Marin Vujic, Yeonjoo Hwang, Kevin Lai, Stephanie Chen, Thuan Nguyen, Denise P Muñoz, Yoshinori Kohwi, Christian Posch, Adil Daud, Klemens Rappersberger, Terumi Kohwi-Shigematsu, Jean-Philippe Coppé, Susana Ortiz-Urda

Publikováno v: Molecular Cancer, Vol 23, Iss 1, Pp 1-21 (2024)

Abstract Finding effective therapeutic targets to treat NRAS-mutated melanoma remains a challenge. Long non-coding RNAs (lncRNAs) recently emerged as essential regulators of tumorigenesis. Using a discovery approach combining experimental models and

Externí odkaz: https://doaj.org/article/d39bbf99048b49ce889263e2e9a46308

Abstract B016: Inhibition of KRASG12C in colon cancer illustrates a link between beta-catenin, WNK, and the GID complex

Autor: Kasturi Nayak, Yeonjoo Hwang, LeeAnn Wang, Danielle L. Swaney, Nevan J. Krogan, John D. Gordan

Publikováno v: Cancer Research. 82:B016-B016

KRAS is mutated in 35%-45% of colorectal cancers (CRC), and KRAS mutational status determines the prognosis and therapeutic options available to patients with advanced CRC. Direct KRASG12C inhibitors have proven to be highly effective for patients wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1270fe9833a4d7097658413d0aaf05bd
https://doi.org/10.1158/1538-7445.crc22-b016

The long non-coding RNA ‘TRASH’ is essential for cell survival in MAPK-driven melanoma

Autor: Valentin Feichtenschlager, Linan Chen, Yixuan Zheng, Wilson Ho, Martina Sanlorenzo, Igor Vujic, Eleanor Fewings, Albert Lee, Christopher Chen, Kevin Lin, Ciara Callanan, Marin Vujic, Yeonjoo Hwang, Kevin Lai, Stephanie Chen, Thuan Nguyen, Denise Muñoz, Yoshinori Kohwi, Christian Posch, Adil Daud, Klemens Rappersberger, Terumi Kohwi-Shigematsu, Jean-Philippe Coppé, Susana Ortiz-Urda

MAPK-pathway up-regulation is responsible for over 40% of human cancer cases. Finding effective therapeutic targets for melanoma therapy continues to be a challenge due to drug resistance. Using a computational and experimental pipeline, we discovere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::249eaa59ad33bbcbb47ccfffceaf86f4
https://doi.org/10.21203/rs.3.rs-1297358/v1

The therapeutically actionable long non-coding RNA 'T-RECS' is essential to cancer cells' survival in NRAS/MAPK-driven melanoma.

Autor: Feichtenschlager, Valentin^1,2 (AUTHOR) valentin.feichtenschlager@hotmail.com, Chen, Linan¹ (AUTHOR), Zheng, Yixuan James^1,3 (AUTHOR), Ho, Wilson¹ (AUTHOR), Sanlorenzo, Martina¹ (AUTHOR), Vujic, Igor^1,2,4 (AUTHOR), Fewings, Eleanor¹ (AUTHOR), Lee, Albert¹ (AUTHOR), Chen, Christopher¹ (AUTHOR), Callanan, Ciara¹ (AUTHOR), Lin, Kevin¹ (AUTHOR), Qu, Tiange⁵ (AUTHOR), Hohlova, Dasha^1,6 (AUTHOR), Vujic, Marin^1,2 (AUTHOR), Hwang, Yeonjoo⁷ (AUTHOR), Lai, Kevin¹ (AUTHOR), Chen, Stephanie¹ (AUTHOR), Nguyen, Thuan¹ (AUTHOR), Muñoz, Denise P⁷ (AUTHOR), Kohwi, Yoshinori⁵ (AUTHOR)

Publikováno v: Molecular Cancer. 2/22/2024, Vol. 23 Issue 1, p1-21. 21p.

Data from University of California San Francisco (UCSF) Broaden Understanding of Cancer Gene Therapy (The therapeutically actionable long non-coding RNA 'T-RECS' is essential to cancer cells' survival in NRAS/MAPK-driven melanoma).

Publikováno v: Cancer Gene Therapy Week; 3/18/2024, p18-18, 1p