Zobrazeno 1 - 5 of 5 pro vyhledávání: '"Yeonjoo Chung"'
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Akademický článek
NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency
Autor: Joana G Marques, Berkley E Gryder, Blaz Pavlovic, Yeonjoo Chung, Quy A Ngo, Fabian Frommelt, Matthias Gstaiger, Young Song, Katharina Benischke, Dominik Laubscher, Marco Wachtel, Javed Khan, Beat W Schäfer
Publikováno v: eLife, Vol 9 (2020)
The NuRD complex subunit CHD4 is essential for fusion-positive rhabdomyosarcoma (FP-RMS) survival, but the mechanisms underlying this dependency are not understood. Here, a NuRD-specific CRISPR screen demonstrates that FP-RMS is particularly sensitiv
Externí odkaz: https://doaj.org/article/d33cd1744564400abf93c1226f3c6a09
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4
NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency
Autor: Blaz Pavlovic, Javed Khan, Yeonjoo Chung, Marco Wachtel, Young K. Song, Beat W. Schäfer, Quy A. Ngo, Joana G. Marques, Matthias Gstaiger, Fabian Frommelt, Berkley E. Gryder, Dominik Laubscher, Katharina Benischke
Publikováno v: eLife, Vol 9 (2020)
eLife
eLife, 9
The NuRD complex subunit CHD4 is essential for fusion-positive rhabdomyosarcoma (FP-RMS) survival, but the mechanisms underlying this dependency are not understood. Here, a NuRD-specific CRISPR screen demonstrates that FP-RMS is particularly sensitiv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf9b081301749f709d71b7bba0d1d825
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5
Abstract PO-009: Disrupting chromatin architecture: The NuRD subunit and ATPase CHD4 as a new therapeutic target in pediatric sarcoma
Autor: Yeonjoo Chung, Beat W. Schäfer, Joana G. Marques, Marco Wachtel, Berkley E. Gryder, Blaz Pavlovic, Quy A. Ngo, Javed Khan
Publikováno v: Cancer Research. 80:PO-009
Cancer-specific chromosomal aberrations producing chimeric fusion genes are recurrently found in pediatric sarcomas. Fusion positive rhabdomyosarcoma (FP-RMS) and Ewing sarcoma (ES) are two rare but lethal pediatric malignancies driven by such chromo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72afedcb85183b568c36d8bf6d4c06f4
https://doi.org/10.1158/1538-7445.epimetab20-po-009
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