Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Yeon-Suk Yang"'
Autor:
Yeon-Suk Yang, Tadatoshi Sato, Sachin Chaugule, Hong Ma, Jun Xie, Guangping Gao, Jae-Hyuck Shim
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 1, Pp 102111- (2024)
Osteogenesis imperfecta (OI) is a genetic disorder characterized by bone fragility, low bone mass, fractures, and extraskeletal manifestations. Since OI is commonly caused by single-nucleotide mutation(s) in the COL1A1 or COL1A2 genes encoding type I
Externí odkaz:
https://doaj.org/article/ec898dcefb954a6485808c098630bb89
Autor:
Chujiao Lin, Qiyuan Yang, Dongsheng Guo, Jun Xie, Yeon-Suk Yang, Sachin Chaugule, Ngoc DeSouza, Won-Taek Oh, Rui Li, Zhihao Chen, Aijaz A. John, Qiang Qiu, Lihua Julie Zhu, Matthew B. Greenblatt, Sankar Ghosh, Shaoguang Li, Guangping Gao, Cole Haynes, Charles P. Emerson, Jae-Hyuck Shim
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Skeletal progenitors provide a reservoir for bone-forming osteoblasts. However, the major energy source for their osteogenesis remains unresolved. Here, the authors demonstrate that ESCIT-mediated regulation of mitochondrial metabolism is required fo
Externí odkaz:
https://doaj.org/article/7ba9a8c0d31344639b3d19b6b3e7140e
Autor:
Yeon-Suk Yang, Jung-Min Kim, Jun Xie, Sachin Chaugule, Chujiao Lin, Hong Ma, Edward Hsiao, Jaehyoung Hong, Hyonho Chun, Eileen M. Shore, Frederick S. Kaplan, Guangping Gao, Jae-Hyuck Shim
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Fibrodysplasia ossificans progressiva is an ultra-rare genetic disorder with progressive heterotopic ossification. Yang et al develop different gene therapy approaches and show their efficacy in mouse models and in human induced pluripotent stem cell
Externí odkaz:
https://doaj.org/article/261d337857a4449b8131eb048cff41f6
Autor:
Aijaz Ahmad John, Jun Xie, Yeon-Suk Yang, Jung-Min Kim, Chujiao Lin, Hong Ma, Guangping Gao, Jae-Hyuck Shim
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 296-311 (2022)
Osteoporosis occurs due to a dysregulation in bone remodeling, a process requiring both bone-forming osteoblasts and bone-resorbing osteoclasts. Current leading osteoporosis therapies suppress osteoclast-mediated bone resorption but show limited ther
Externí odkaz:
https://doaj.org/article/6a863fcf948c40ecacdf2bebc2956fdb
Autor:
Yeon-Suk Yang, Chujiao Lin, Hong Ma, Jun Xie, Frederick S. Kaplan, Guangping Gao, Jae-Hyuck Shim
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1364 (2023)
Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic disorder characterized by progressive disabling heterotopic ossification (HO) at extra-skeletal sites. Here, we developed adeno-associated virus (AAV)-based gene therapy that suppre
Externí odkaz:
https://doaj.org/article/40696c78b90643a9a83c19fbbdd827bd
Publikováno v:
Sensors, Vol 23, Iss 18, p 7904 (2023)
Chronic exposure to low concentrations of volatile organic compounds (VOCs), such as chlorobenzene, is not being monitored in industrializing countries, although VOC exposure is associated with carcinogenic, organ-toxic, and endocrine-disrupting effe
Externí odkaz:
https://doaj.org/article/20f66a44c4374cbfad501baf079691c2
Autor:
Jung-Min Kim, Yeon-Suk Yang, Jaehyoung Hong, Sachin Chaugule, Hyonho Chun, Marjolein CH van der Meulen, Ren Xu, Matthew B Greenblatt, Jae-hyuck Shim
Publikováno v:
eLife, Vol 11 (2022)
Emerging evidence supports that osteogenic differentiation of skeletal progenitors is a key determinant of overall bone formation and bone mass. Despite extensive studies showing the function of mitogen-activated protein kinases (MAPKs) in osteoblast
Externí odkaz:
https://doaj.org/article/435d9b2fd74c49e8a18463a57619a847
Autor:
Yeon-Suk Yang, Jun Xie, Sachin Chaugule, Dan Wang, Jung-Min Kim, JiHea Kim, Phillip W.L. Tai, Seok-kyo Seo, Ellen Gravallese, Guangping Gao, Jae-Hyuck Shim
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 922-935 (2020)
Improper activity of bone-resorbing osteoclasts results in low bone density and deterioration of bone structure, which increase the risk of fractures. Anti-resorptive therapies targeting osteoclasts have proven effective in preserving bone mass, but
Externí odkaz:
https://doaj.org/article/22064349b14b4c139f4ec070c7f05b6d
Autor:
Jung-Min Kim, Yeon-Suk Yang, Kwang Hwan Park, Xianpeng Ge, Ren Xu, Na Li, Minkyung Song, Hyunho Chun, Seoyeon Bok, Julia F. Charles, Odile Filhol-Cochet, Brigitte Boldyreff, Teresa Dinter, Paul B. Yu, Ning Kon, Wei Gu, Takeshi Takarada, Matthew B. Greenblatt, Jae-Hyuck Shim
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Runx2 is essential for tuning the generation of bone from skeletal stem cells (SSCs). Here, the authors demonstrate that the CK2/HAUSP pathway stabilizes RUNX2 protein thereby regulating the commitment of SSCs to osteoprogenitors as well as their sub
Externí odkaz:
https://doaj.org/article/d66c7cf3ddb9472bb8083540eab23003
Autor:
Yeon-Suk Yang, Jun Xie, Dan Wang, Jung-Min Kim, Phillip W. L. Tai, Ellen Gravallese, Guangping Gao, Jae-Hyuck Shim
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The adaptor protein SHN3 suppresses new bone formation by controlling osteoblast activity. Here, the authors show that ablation of SHN3 function, either genetically or by delivering an artificial miRNA via AAV9, rescues bone loss in osteoporotic mice
Externí odkaz:
https://doaj.org/article/f5712a6562894f83a8d6b6c45bb24c53