Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Yeon J Lee"'
Autor:
Yeon J Lee, Britt A Glaunsinger
Publikováno v:
PLoS Biology, Vol 7, Iss 5, p e1000107 (2009)
Regulation of messenger RNA (mRNA) stability plays critical roles in controlling gene expression, ensuring transcript fidelity, and allowing cells to respond to environmental cues. Unregulated enhancement of mRNA turnover could therefore dampen cellu
Externí odkaz:
https://doaj.org/article/3baa2fc7b1374ca8af3088ee1492ddaf
Autor:
Jacques Greenberg, Jessica Limberg, Akanksha Verma, David Kim, Xiang Chen, Yeon J. Lee, Maureen D. Moore, Timothy M. Ullmann, Jessica W. Thiesmeyer, Zachary Loewenstein, Kevin J. Chen, Caitlin E. Egan, Dessislava Stefanova, Rohan Bareja, Rasa Zarnegar, Brendan M. Finnerty, Theresa Scognamiglio, Yi-Chieh Nancy Du, Olivier Elemento, Thomas J. Fahey III, Irene M. Min
Publikováno v:
JCI Insight, Vol 7, Iss 23 (2022)
Pancreatic neuroendocrine tumors (PNETs) are malignancies arising from the islets of Langerhans. Therapeutic options are limited for the over 50% of patients who present with metastatic disease. We aimed to identify mechanisms to remodel the PNET tum
Externí odkaz:
https://doaj.org/article/6f96a988d4f44b32a06c2793e68c3f00
Autor:
Jessica Limberg, Yeon J. Lee-Saxton, Caitlin E. Egan, AlAnoud AlAnazi, Imaani Easthausen, Dessislava Stefanova, Alexia Stamatiou, Toni Beninato, Rasa Zarnegar, Theresa Scognamiglio, Thomas J. Fahey, Brendan M. Finnerty
Publikováno v:
Annals of Surgical Oncology. 30:3570-3577
Autor:
Jessica Limberg, Yeon J. Lee-Saxton, Caitlin E. Egan, AlAnoud AlAnazi, Imaani Easthausen, Dessislava Stefanova, Alexia Stamatiou, Toni Beninato, Rasa Zarnegar, Theresa Scognamiglio, Thomas J. Fahey, Brendan M. Finnerty
Publikováno v:
Annals of Surgical Oncology. 30:3578-3579
Autor:
Verena M. Link, David Gonzalez, John D. Lapek, Yeon J. Lee, Christopher K. Glass, Manuel Kaulich, Steven F. Dowdy
Publikováno v:
Scientific reports, vol 11, iss 1
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
During early G1 phase, Rb is exclusively mono-phosphorylated by cyclin D:Cdk4/6, generating 14 different isoforms with specific binding patterns to E2Fs and other cellular protein targets. While mono-phosphorylated Rb is dispensable for early G1 phas
Autor:
Carlos Alfonso-Gonzalez, Michael Rauer, Valérie Hilgers, Gerhard Mittler, Barbara Hummel, Qingqing Wang, Dominika Grzejda, Judit Carrasco, Monika Puchalska, Yeon J. Lee
Publikováno v:
Molecular Cell
Summary The production of alternative RNA variants contributes to the tissue-specific regulation of gene expression. In the animal nervous system, a systematic shift toward distal sites of transcription termination produces transcript signatures that
Autor:
Qingqing Wang, Judit Carrasco, Yeon J. Lee, Gerhard Mittler, Monika Puchalska, Carlos Alfonso-Gonzalez, Dominika Grzejda, Michael Rauer, Barbara Hummel, Valérie Hilgers
Publikováno v:
SSRN Electronic Journal.
The production of alternative RNA variants contributes to the tissue-specific regulation of gene expression. In the animal nervous system, a systematic shift towards distal sites of transcription termination produces transcript signatures that are cr
Publikováno v:
Genes & Development. 32:1060-1074
Alternative premessenger RNA (pre-mRNA) splicing is a post-transcriptional mechanism for controlling gene expression. Splicing patterns are determined by both RNA-binding proteins and nuclear pre-mRNA structure. Here, we analyzed pre-mRNA splicing pa
Autor:
Hyun J, Lee, Dong H, Shin, Yeon J, Lee, So J, Lee, Chung S, Hwang, Ahrong, Kim, Won Y, Park, Jung H, Lee, Kyung U, Choi, Jee Y, Kim, Chang H, Lee, Mee Y, Sol, Sung W, Park
Publikováno v:
HistopathologyReferences. 76(5)
Interaction between programmed death-1 ligand (PD-L1) and its receptor programmed death 1 (PD-1) on T cells inactivates antitumour immune responses. PD-L1 expression has been associated with poor prognosis in renal cell carcinoma (RCC) and predicts a
Publikováno v:
Journal of virology, vol 87, iss 8
Hutin, S; Lee, Y; & Glaunsinger, BA. (2013). An RNA element in human interleukin 6 confers escape from degradation by the Gammaherpesvirus SOX protein. Journal of Virology, 87(8), 4672-4682. doi: 10.1128/JVI.00159-13. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/1fk2w54c
Hutin, S; Lee, Y; & Glaunsinger, BA. (2013). An RNA element in human interleukin 6 confers escape from degradation by the Gammaherpesvirus SOX protein. Journal of Virology, 87(8), 4672-4682. doi: 10.1128/JVI.00159-13. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/1fk2w54c
Several viruses express factors to silence host gene expression via widespread mRNA degradation. This phenotype is the result of the coordinated activity of the viral endonuclease SOX and the cellular RNA degradation enzyme Xrn1 during lytic Kaposi's