Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Yeon Ha Ju"'
Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in Alzheimer’s disease
Autor:
Suhyun Kim, Heejung Chun, Yunha Kim, Yeyun Kim, Uiyeol Park, Jiyeon Chu, Mridula Bhalla, Seung-Hye Choi, Ali Yousefian-Jazi, Sojung Kim, Seung Jae Hyeon, Seungchan Kim, Yeonseo Kim, Yeon Ha Ju, Seung Eun Lee, Hyunbeom Lee, Kyungeun Lee, Soo-Jin Oh, Eun Mi Hwang, Junghee Lee, C. Justin Lee, Hoon Ryu
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-26 (2024)
Abstract Background Astrocytes, one of the most resilient cells in the brain, transform into reactive astrocytes in response to toxic proteins such as amyloid beta (Aβ) in Alzheimer’s disease (AD). However, reactive astrocyte-mediated non-cell aut
Externí odkaz:
https://doaj.org/article/10d1c6d648c04589a8cf3caf530fc135
Autor:
Yeon Ha Ju, Jongwook Cho, Ji-Young Park, Hyunjin Kim, Eun-Bin Hong, Ki Duk Park, C. Justin Lee, Euiheon Chung, Hyoung-Ihl Kim, Min-Ho Nam
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 5, Pp 1193-1205 (2024)
Abstract Neuropathic pain is a debilitating condition caused by the hyperexcitability of spinal dorsal horn neurons and is often characterized by allodynia. Although neuron-independent mechanisms of hyperexcitability have been investigated, the contr
Externí odkaz:
https://doaj.org/article/33cfa45280e4488da082dc4892647469
Autor:
Yeon Ha Ju, Jongwook Cho, Ji-Young Park, Hyunjin Kim, Eun-Bin Hong, Ki Duk Park, C. Justin Lee, Euiheon Chung, Hyoung-Ihl Kim, Min-Ho Nam
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 8, Pp 1887-1887 (2024)
Externí odkaz:
https://doaj.org/article/fc1b77a414ac44a3acba8d0a37df5c14
Autor:
Dong Ho Woo, Jin Young Bae, Min-Ho Nam, Heeyoung An, Yeon Ha Ju, Joungha Won, Jae Hyouk Choi, Eun Mi Hwang, Kyung-Seok Han, Yong Chul Bae, C. Justin Lee
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Recently, μ-opioid receptor (MOR), one of the well-known Gi-protein coupled receptors (Gi-GPCR), was reported to be highly expressed in the hippocampal astrocytes. However, the role of astrocytic MOR has not been investigated. Here we report that ac
Externí odkaz:
https://doaj.org/article/23b9dd31729f4147a934b5486bfa15c7
Autor:
Barnett, Daniel, Bohmbach, Kirsten, Grelot, Valentin, Charlet, Alexandre, Dallérac, Glenn, Yeon Ha Ju, Jun Nagai, Orr, Anna G.
Publikováno v:
Journal of Neuroscience; 11/8/2023, Vol. 43 Issue 45, p7463-7471, 9p
Molecular identification of ALDH1A1 and SIRT2 in the astrocytic putrescine-to-GABA metabolic pathway
Autor:
Mridula Bhalla, Jeong Im Shin, Yeon Ha Ju, Yongmin Mason Park, Seonguk Yoo, Hyeon Beom Lee, C Justin Lee
GABA (γ-aminobutyric acid) is the primary inhibitory neurotransmitter in the CNS. In astrocytes, GABA is synthesized by degradation of putrescine by monoamine oxidase B (MAO-B), a process which is known to mediate tonic inhibition of neuronal excita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77e329b59b9221d5beaaa32a8b1cee83
https://doi.org/10.1101/2023.01.11.523573
https://doi.org/10.1101/2023.01.11.523573
Autor:
Yeon Ha Ju, Ae Nim Pae, Minwoo Wendy Jang, Lizaveta Gotina, Tai Young Kim, Seungtaek Kim, Young-Ho Jang, C. Justin Lee, Sangeun Jeon, Mingu Gordon Park, Woojin Won, Sunpil Kim, Sunkyu Han, Joungha Won
Publikováno v:
Experimental & Molecular Medicine
An ongoing pandemic of coronavirus disease 2019 (COVID-19) is now the greatest threat to global public health. Herbal medicines and their derived natural products have drawn much attention in the treatment of COVID-19, but the detailed mechanisms by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da874173612627640fc6cb0dbeb7a597
https://doi.org/10.1038/s12276-021-00624-9
https://doi.org/10.1038/s12276-021-00624-9
Autor:
Soowon Park, Seung Eun Lee, Joungha Won, Yuriy Pankratov, Minwoo Wendy Jang, Sunpil Kim, Sangkyu Lee, Won Do Heo, Yeon Ha Ju, Arie Kim, C. Justin Lee
Summary Spatiotemporal control of brain activity by optogenetics has emerged as an essential tool to study brain function. For silencing brain activity, optogenetic probes, such as halorhodopsin and archaerhodopsin, inhibit transmitter release indire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3953a37b95722ff14b1727bca40bbaf
http://wrap.warwick.ac.uk/161166/1/WRAP-opto-vTrap-optogenetic-trap-vesicular-release-synaptic-transmission-behavior-Pankratov-2022.pdf
http://wrap.warwick.ac.uk/161166/1/WRAP-opto-vTrap-optogenetic-trap-vesicular-release-synaptic-transmission-behavior-Pankratov-2022.pdf
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 3
Pages: 2491
Volume 24
Issue 3
Pages: 2491
Parkinson’s disease (PD) is a neurodegenerative disorder with typical motor symptoms. Recent studies have suggested that excessive GABA from reactive astrocytes tonically inhibits dopaminergic neurons and reduces the expression of tyrosine hydroxyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2770bd3c18c37c888021eefc9393deb9
https://doi.org/10.3390/ijms24032491
https://doi.org/10.3390/ijms24032491
Autor:
Yeon Ha Ju, Mridula Bhalla, Seung Jae Hyeon, Ju Eun Oh, Seonguk Yoo, Uikyu Chae, Jea Kwon, Wuhyun Koh, Jiwoon Lim, Yongmin Mason Park, Junghee Lee, Il-Joo Cho, Hyunbeom Lee, Hoon Ryu, C. Justin Lee
Publikováno v:
Cell metabolism. 34(8)
Alzheimer's disease (AD) is one of the foremost neurodegenerative diseases, characterized by beta-amyloid (Aβ) plaques and significant progressive memory loss. In AD, astrocytes are proposed to take up and clear Aβ plaques. However, how Aβ induces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b639a42997778bbac7c6adff29fd8fd7
https://pubmed.ncbi.nlm.nih.gov/35921813
https://pubmed.ncbi.nlm.nih.gov/35921813