Inhibitors of the Thioesterase Activity of Mycobacterium tuberculosis Pks13 Discovered Using DNA-Encoded Chemical Library Screening.

Autor: Krieger IV; Department of Biochemistry & Biophysics, Texas A&M University, College Station, Texas 77843, United States., Yalamanchili S; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., Dickson P; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., Engelhart CA; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York 10021, United States., Zimmerman MD; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States., Wood J; Department of Biochemistry & Biophysics, Texas A&M University, College Station, Texas 77843, United States., Clary E; Department of Biochemistry & Biophysics, Texas A&M University, College Station, Texas 77843, United States., Nguyen J; Department of Biochemistry & Biophysics, Texas A&M University, College Station, Texas 77843, United States., Thornton N; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York 10021, United States., Centrella PA; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., Chan B; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.; Auron Therapeutics, 55 Chapel Street, Newton, Massachusetts 02458, United States., Cuozzo JW; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.; Relay Therapeutics, 399 Binney Street, Cambridge, Massachusetts 02141, United States., Gengenbacher M; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States., Guié MA; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., Guilinger JP; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., Bienstock C; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., Hartl H; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.; Orogen Therapeutics, 12 Gill Street, Woburn, Massachusetts 01801, United States., Hupp CD; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.; Ipsen Bioscience Inc., 1 Main Street, Cambridge, Massachusetts 02142, United States., Jetson R; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.; Valo Health, 75 Hayden Avenue, Lexington, Massachusetts 02141, United States., Satoh T; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.; EXO Therapeutics, 150 Cambridgepark Drive, suite 300, Cambridge, Massachusetts 02140, United States., Yeoman JTS; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.; Recludix Pharmaceuticals, 222 Third Street, Cambridge, Massachusetts 02142, United States., Zhang Y; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., Dartois V; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States.; Hackensack Meridian School of Medicine, Hackensack Meridian Health, Nutley, New Jersey 07110, United States., Schnappinger D; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York 10021, United States., Keefe AD; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States., Sacchettini JC; Department of Biochemistry & Biophysics, Texas A&M University, College Station, Texas 77843, United States.

Publikováno v: ACS infectious diseases [ACS Infect Dis] 2024 May 10; Vol. 10 (5), pp. 1561-1575. Date of Electronic Publication: 2024 Apr 05.