A broadly cross-reactive i-body to AMA1 potently inhibits blood and liver stages of Plasmodium parasites.

Autor: Angage D; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Sciences, La Trobe University, Victoria, 3086, Australia., Chmielewski J; Research Centre for Infectious Diseases, School of Biological Sciences, The University of Adelaide, Adelaide, South Australia, 5005, Australia., Maddumage JC; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Sciences, La Trobe University, Victoria, 3086, Australia., Hesping E; Infectious Diseases & Immune Defense Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, 3052, Australia., Caiazzo S; Infectious Diseases & Immune Defense Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, 3052, Australia., Lai KH; Research Centre for Infectious Diseases, School of Biological Sciences, The University of Adelaide, Adelaide, South Australia, 5005, Australia., Yeoh LM; Burnet Institute, Melbourne, Victoria, 3004, Australia.; Department of Medicine, The University of Melbourne, Parkville, Victoria, 3052, Australia., Menassa J; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Sciences, La Trobe University, Victoria, 3086, Australia., Opi DH; Burnet Institute, Melbourne, Victoria, 3004, Australia.; Department of Medicine, The University of Melbourne, Parkville, Victoria, 3052, Australia.; Central Clinical School and Department of Microbiology, Monash University, Clayton, Victoria, 3800, Australia., Cairns C; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Sciences, La Trobe University, Victoria, 3086, Australia., Puthalakath H; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Sciences, La Trobe University, Victoria, 3086, Australia., Beeson JG; Burnet Institute, Melbourne, Victoria, 3004, Australia.; Central Clinical School and Department of Microbiology, Monash University, Clayton, Victoria, 3800, Australia.; Department of Infectious Diseases, The University of Melbourne, Parkville, Victoria, 3052, Australia., Kvansakul M; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Sciences, La Trobe University, Victoria, 3086, Australia., Boddey JA; Infectious Diseases & Immune Defense Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, 3052, Australia., Wilson DW; Research Centre for Infectious Diseases, School of Biological Sciences, The University of Adelaide, Adelaide, South Australia, 5005, Australia.; Burnet Institute, Melbourne, Victoria, 3004, Australia.; Institute for Photonics and Advanced Sensing (IPAS), University of Adelaide, Adelaide, South Australia, 5005, Australia., Anders RF; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Sciences, La Trobe University, Victoria, 3086, Australia., Foley M; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Sciences, La Trobe University, Victoria, 3086, Australia. m.foley@latrobe.edu.au.; AdAlta, Science Drive, Bundoora, Victoria, 3083, Australia. m.foley@latrobe.edu.au.

Publikováno v: Nature communications [Nat Commun] 2024 Aug 22; Vol. 15 (1), pp. 7206. Date of Electronic Publication: 2024 Aug 22.

A Diversity Covering (DiCo) Plasmodium vivax apical membrane antigen-1 vaccine adjuvanted with RFASE/RSL10 yields high levels of growth-inhibitory antibodies.

Autor: Faber BW; Department of Parasitology, Biomedical Primate Research Centre, Rijswijk, the Netherlands. Electronic address: Faber@bprc.nl., Yeoh LM; Burnet Institute, Melbourne, Victoria, Australia; Department of Medicine, The University of Melbourne, Victoria, Australia., Kurtovic L; Burnet Institute, Melbourne, Victoria, Australia; Central Clinical School and Department of Microbiology, Monash University, Victoria, Australia., Mol WEM; Immunovo BV Den Bosch, the Netherlands., Poelert M; Symeres, Groningen, the Netherlands., Smits E; Symeres, Groningen, the Netherlands., Rodriguez Garcia R; Department of Parasitology, Biomedical Primate Research Centre, Rijswijk, the Netherlands., Mandalawi-Van der Eijk M; Department of Parasitology, Biomedical Primate Research Centre, Rijswijk, the Netherlands., van der Werff N; Department of Parasitology, Biomedical Primate Research Centre, Rijswijk, the Netherlands., Voorberg-van der Wel A; Department of Parasitology, Biomedical Primate Research Centre, Rijswijk, the Netherlands., Remarque EJ; Department of Virology, Biomedical Primate Research Centre, Rijswijk, the Netherlands., Beeson JG; Burnet Institute, Melbourne, Victoria, Australia; Central Clinical School and Department of Microbiology, Monash University, Victoria, Australia; Department of Infectious Diseases, University of Melbourne, Victoria, Australia., Kocken CHM; Department of Parasitology, Biomedical Primate Research Centre, Rijswijk, the Netherlands.

Publikováno v: Vaccine [Vaccine] 2024 Mar 07; Vol. 42 (7), pp. 1785-1792. Date of Electronic Publication: 2024 Feb 16.

The direct binding of Plasmodium vivax AMA1 to erythrocytes defines a RON2-independent invasion pathway.

Autor: Lee SK; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852., Low LM; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852., Andersen JF; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852., Yeoh LM; Burnet Institute, Melbourne, VIC 3004, Australia., Valenzuela Leon PC; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852., Drew DR; Burnet Institute, Melbourne, VIC 3004, Australia., Doehl JSP; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852., Calvo E; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852., Miller LH; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852., Beeson JG; Burnet Institute, Melbourne, VIC 3004, Australia.; Central Clinical School and Department of Microbiology, Monash University, VIC 3004, Australia.; Department of Infectious Diseases, University of Melbourne, VIC 3010, Australia., Gunalan K; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Jan 03; Vol. 120 (1), pp. e2215003120. Date of Electronic Publication: 2022 Dec 28.

Advances in Plasmodium research, an update: Highlights from the Malaria in Melbourne 2021 conference.

Autor: Adderley J; School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia., Boulet C; Life Sciences, Burnet Institute, Melbourne, Victoria, Australia., McCann K; Institute of Mental and Physical Health and Clinical Translation (IMPACT) and School of Medicine, Deakin University, Geelong, Victoria, Australia., McHugh E; Department of Biochemistry and Pharmacology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, Australia., Ioannidis LJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia. Electronic address: ioannidis@wehi.edu.au., Yeoh LM; Life Sciences, Burnet Institute, Melbourne, Victoria, Australia; Department of Medicine, The University of Melbourne, Parkville, Victoria, Australia. Electronic address: lee.yeoh@burnet.edu.au.

Publikováno v: Molecular and biochemical parasitology [Mol Biochem Parasitol] 2022 Jul; Vol. 250, pp. 111487. Date of Electronic Publication: 2022 May 21.

Histone modifications associated with gene expression and genome accessibility are dynamically enriched at Plasmodium falciparum regulatory sequences.

Autor: Tang J; Department of Medicine, The University of Melbourne, Royal Melbourne Hospital, Parkville, VIC, 3050, Australia.; School of Medicine, Faculty of Health, Deakin University, Geelong Waurn Ponds Campus, Waurn Ponds, VIC, 3216, Australia., Chisholm SA; School of BioSciences, The University of Melbourne, Parkville, VIC, 3052, Australia.; Bio21 Institute, Parkville, VIC, 3052, Australia., Yeoh LM; Bio21 Institute, Parkville, VIC, 3052, Australia.; Peter Doherty Institute, Melbourne, VIC, 3000, Australia.; Department of Microbiology and Immunology, The University of Melbourne, Victoria, 3000, Australia., Gilson PR; Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, VIC, 3004, Australia.; Monash University, Melbourne, VIC, 3800, Australia., Papenfuss AT; Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Mathematics and Statistics, University of Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.; Sir Peter MacCallum, Department of Oncology, University of Melbourne, Parkville, VIC, Australia., Day KP; Bio21 Institute, Parkville, VIC, 3052, Australia.; Peter Doherty Institute, Melbourne, VIC, 3000, Australia.; Department of Microbiology and Immunology, The University of Melbourne, Victoria, 3000, Australia., Petter M; Department of Medicine, The University of Melbourne, Royal Melbourne Hospital, Parkville, VIC, 3050, Australia.; Erlangen University, 91054, Erlangen, Germany., Duffy MF; Department of Medicine, The University of Melbourne, Royal Melbourne Hospital, Parkville, VIC, 3050, Australia. mduffy@unimelb.edu.au.; Bio21 Institute, Parkville, VIC, 3052, Australia. mduffy@unimelb.edu.au.; Peter Doherty Institute, Melbourne, VIC, 3000, Australia. mduffy@unimelb.edu.au.; Department of Microbiology and Immunology, The University of Melbourne, Victoria, 3000, Australia. mduffy@unimelb.edu.au.

Publikováno v: Epigenetics & chromatin [Epigenetics Chromatin] 2020 Nov 23; Vol. 13 (1), pp. 50. Date of Electronic Publication: 2020 Nov 23.