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Autor:
Chun-Gyu Kim, C. Richard Hutchinson, Li Tang, Tin-Wein Yu, Matthew P. Taylor, Yeo J. Yoon, Paul R. August, Heinz G. Floss, Sandra Ning, Dietmar Hoffmann, Rolf Müller, Xiaohong Zhang
Publikováno v:
Chemistrybiology. 5(2)
Background: The ansamycin class of antibiotics are produced by various Actinomycetes. Their carbon framework arises from the polyketide pathway via a polyketide synthase (PKS) that uses an unusual starter unit. Rifamycin (rif), produced by Amycolatop