The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression

Autor: Hung, T, Pratt, GA, Sundararaman, B, Townsend, MJ, Chaivorapol, C, Bhangale, T, Graham, RR, Ortmann, W, Criswell, LA, Yeo, GW, Behrens, TW

Publikováno v: Science (New York, N.Y.), vol 350, iss 6259

Autoantibodies target the RNA binding protein Ro60 in systemic lupus erythematosus (SLE) and Sjögren's syndrome. However, it is unclear whether Ro60 and its associated RNAs contribute to disease pathogenesis. We catalogued the Ro60-associated RNAs i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::af0aee56843c520b3ca5a306435e76aa
https://escholarship.org/uc/item/8kk9514h

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Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes.

Autor: Al-Azzam N; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA; Sanford Stem Cell Institute Innovation Center and Stem Cell Program, University of California San Diego, La Jolla, CA, USA; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA; Neurosciences Graduate Program, University of California San Diego, San Diego, CA, USA., To JH; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA; Sanford Stem Cell Institute Innovation Center and Stem Cell Program, University of California San Diego, La Jolla, CA, USA; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA., Gautam V; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA; Sanford Stem Cell Institute Innovation Center and Stem Cell Program, University of California San Diego, La Jolla, CA, USA; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA., Street LA; Department of Biological Sciences, Columbia University, New York, NY, USA., Nguyen CB; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA; Sanford Stem Cell Institute Innovation Center and Stem Cell Program, University of California San Diego, La Jolla, CA, USA; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA., Naritomi JT; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA; Sanford Stem Cell Institute Innovation Center and Stem Cell Program, University of California San Diego, La Jolla, CA, USA; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA., Lam DC; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA; Sanford Laboratories for Innovative Medicines, San Diego, CA, USA., Madrigal AA; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA; Department of Biological Sciences Graduate Program, University of California San Diego, La Jolla, CA, USA., Lee B; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA; Sanford Stem Cell Institute Innovation Center and Stem Cell Program, University of California San Diego, La Jolla, CA, USA; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA., Jin W; Sanford Laboratories for Innovative Medicines, San Diego, CA, USA., Avina A; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA; Sanford Stem Cell Institute Innovation Center and Stem Cell Program, University of California San Diego, La Jolla, CA, USA; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA., Mizrahi O; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA; Sanford Stem Cell Institute Innovation Center and Stem Cell Program, University of California San Diego, La Jolla, CA, USA; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA., Mueller JR; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA; Sanford Stem Cell Institute Innovation Center and Stem Cell Program, University of California San Diego, La Jolla, CA, USA; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA., Ford W; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA; Sanford Stem Cell Institute Innovation Center and Stem Cell Program, University of California San Diego, La Jolla, CA, USA; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA., Schiavon CR; Department of Cell and Developmental Biology, University of California San Diego, La Jolla, CA, USA; Waitt Advanced Biophotonics Center, Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA., Rebollo E; Department of Cell and Developmental Biology, University of California San Diego, La Jolla, CA, USA; Waitt Advanced Biophotonics Center, Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA., Vu AQ; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA; Sanford Stem Cell Institute Innovation Center and Stem Cell Program, University of California San Diego, La Jolla, CA, USA; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA., Blue SM; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA; Sanford Stem Cell Institute Innovation Center and Stem Cell Program, University of California San Diego, La Jolla, CA, USA; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA., Madakamutil YL; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA; Sanford Stem Cell Institute Innovation Center and Stem Cell Program, University of California San Diego, La Jolla, CA, USA; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA., Manor U; Department of Cell and Developmental Biology, University of California San Diego, La Jolla, CA, USA; Waitt Advanced Biophotonics Center, Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA., Rothstein JD; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Coyne AN; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Jovanovic M; Department of Biological Sciences, Columbia University, New York, NY, USA., Yeo GW; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA; Sanford Stem Cell Institute Innovation Center and Stem Cell Program, University of California San Diego, La Jolla, CA, USA; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA; Sanford Laboratories for Innovative Medicines, San Diego, CA, USA. Electronic address: geneyeo@ucsd.edu.

Publikováno v: Neuron [Neuron] 2024 Dec 18; Vol. 112 (24), pp. 4033-4047.e8. Date of Electronic Publication: 2024 Oct 31.

Supra- and sub-threshold intracellular-like recording of 2D and 3D neuronal networks using nanopillar electrode arrays.

Autor: Shukla S; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, 92093, USA.; Aiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, CA, 92093, USA., Schwartz JL; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, 92093, USA., Walsh C; Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Wong WM; Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Patel V; Aiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, CA, 92093, USA., Hsieh YP; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, 92093, USA., Onwuasoanya C; Aiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, CA, 92093, USA., Chen S; Aiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, CA, 92093, USA., Offenhäusser A; Institute of Biological Information Processing-Bioelectronics, IBI-3, Forschungszentrum Jülich, Jülich, 52428, Germany., Cauwenberghs G; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, 92093, USA., Santoro F; Institute of Biological Information Processing-Bioelectronics, IBI-3, Forschungszentrum Jülich, Jülich, 52428, Germany.; Neuroelectronic Interfaces, Faculty of Electrical Engineering and IT, RWTH Aachen, Aachen, 52074, Germany., Muotri AR; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093, USA.; Department of Pediatrics, University of California San Diego, San Diego, CA, USA.; Center for Academic Research and Training in Anthropogeny (CARTA) and Archealization (ArchC), University of California San Diego, La Jolla, CA, 92093, USA.; Sanford Stem Cell Education and Integrated Space Stem Cell Orbital Research (ISSCOR) Center University of California San Diego, La Jolla, CA, 92093, USA., Yeo GW; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, 92093, USA.; Sanford Stem Cell Institute Innovation Center, University of California San Diego, La Jolla, CA, 92093, USA.; Center for RNA Technologies and Therapeutics, University of California San Diego, La Jolla, CA, 92093, USA., Chalasani SH; Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Jahed Z; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, 92093, USA. Zjahed@ucsd.edu.; Aiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, CA, 92093, USA. Zjahed@ucsd.edu.

Publikováno v: Microsystems & nanoengineering [Microsyst Nanoeng] 2024 Dec 05; Vol. 10 (1), pp. 184. Date of Electronic Publication: 2024 Dec 05.