Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Yentl Evgy"'
Autor:
Anita Sapoznikov, Yentl Evgy, Amir Ben-Shmuel, Arieh Schwartz, Ron Alcalay, Moshe Aftalion, Alon Ben David, Noam Erez, Reut Falach
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Ricin, an extremely potent toxin produced from the seeds of castor plant, Ricinus communis, is ribosome-inactivating protein that blocks cell-protein synthesis. It is considered a biological threat due to worldwide availability of castor bea
Externí odkaz:
https://doaj.org/article/428856100ea14947af039aa2bd97b53f
Long-Term Pulmonary Damage in Surviving Antitoxin-Treated Mice following a Lethal Ricin Intoxication
Autor:
Yoav Gal, Anita Sapoznikov, Shlomi Lazar, David Shoseyov, Moshe Aftalion, Hila Gutman, Yentl Evgy, Rellie Gez, Reinat Nevo, Reut Falach
Publikováno v:
Toxins, Vol 16, Iss 2, p 103 (2024)
Ricin, a highly potent plant-derived toxin, is considered a potential bioterrorism weapon due to its pronounced toxicity, high availability, and ease of preparation. Acute damage following pulmonary ricinosis is characterized by local cytokine storm,
Externí odkaz:
https://doaj.org/article/86b4dcb62cba4c71932b3d774e92487e
Autor:
Ronit Rosenfeld, Tal Noy-Porat, Adva Mechaly, Efi Makdasi, Yinon Levy, Ron Alcalay, Reut Falach, Moshe Aftalion, Eyal Epstein, David Gur, Theodor Chitlaru, Einat B. Vitner, Sharon Melamed, Boaz Politi, Ayelet Zauberman, Shirley Lazar, Adi Beth-Din, Yentl Evgy, Shmuel Yitzhaki, Shmuel C. Shapira, Tomer Israely, Ohad Mazor
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Here, using the K18-hACE2 transgenic mice model, the authors report the in vivo efficacy of a fully human neutralizing antibody against SARS-CoV-2 and show that when administered before or up to 3 days post infection, treated mice do not exhibit dise
Externí odkaz:
https://doaj.org/article/46809b3d714542f1b041f07ea3d49be0
Autor:
Inbar Cohen-Gihon, Ofir Israeli, Avital Tidhar, Anita Sapoznikov, Yentl Evgy, Dana Stein, Moshe Aftalion, David Gur, Irit Orr, Anat Zvi, Tamar Sabo, Chanoch Kronman, Reut Falach
Publikováno v:
Frontiers in Virology, Vol 2 (2022)
Severe manifestations of coronavirus disease 2019 (COVID-19) are mostly restricted to distinct groups of people who have preexisting morbidities. Most COVID-19 animal models develop a mild pathology that resolves within a relatively short period of t
Externí odkaz:
https://doaj.org/article/11b795ca9d3548e39310a72bb1c3c99f
Autor:
Anita Sapoznikov, Yoav Gal, Ron Alcalay, Yentl Evgy, Tamar Sabo, Chanoch Kronman, Reut Falach
Publikováno v:
Toxins, Vol 14, Iss 9, p 614 (2022)
Abrin is a highly toxic protein obtained from the seeds of the rosary pea plant Abrus precatorius, and it is closely related to ricin in terms of its structure and chemical properties. Both toxins inhibit ribosomal function, halt protein synthesis an
Externí odkaz:
https://doaj.org/article/7a0c3772835641058563a43767788911
Autor:
Reut Falach, Liat Bar-On, Shlomi Lazar, Tamar Kadar, Ohad Mazor, Moshe Aftalion, David Gur, Yentl Evgy, Ohad Shifman, Tamar Aminov, Ofir Israeli, Inbar Cohen-Gihon, Galia Zaide, Hila Gutman, Yaron Vagima, Efi Makdasi, Dana Stein, Ronit Rosenfeld, Ron Alcalay, Eran Zahavy, Haim Levy, Itai Glinert, Amir Ben-Shmuel, Tomer Israely, Sharon Melamed, Boaz Politi, Hagit Achdout, Shmuel Yitzhaki, Chanoch Kronman, Tamar Sabo
Publikováno v:
JCI Insight, Vol 6, Iss 12 (2021)
Mice are normally unaffected by SARS coronavirus 2 (SARS-CoV-2) infection since the virus does not bind effectively to the murine version of the angiotensin-converting enzyme 2 (ACE2) receptor molecule. Here, we report that induced mild pulmonary mor
Externí odkaz:
https://doaj.org/article/f15ac9c77afc452ba0b7c4173a5bfbfe
Autor:
Anita Sapoznikov, Yoav Gal, Yentl Evgy, Moshe Aftalion, Shahaf Katalan, Tamar Sabo, Chanoch Kronman, Reut Falach
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 22, p 12345 (2021)
Ricin toxin isolated from the castor bean (Ricinus communis) is one of the most potent and lethal molecules known. While the pathophysiology and clinical consequences of ricin poisoning by the parenteral route, i.e., intramuscular penetration, have b
Externí odkaz:
https://doaj.org/article/0b91a9f1acf747ff990e8c9006b2be9d
Autor:
Tal Noy-Porat, Avishay Edri, Ron Alcalay, Efi Makdasi, David Gur, Moshe Aftalion, Yentl Evgy, Adi Beth-Din, Yinon Levy, Eyal Epstein, Olga Radinsky, Ayelet Zauberman, Shirley Lazar, Shmuel Yitzhaki, Hadar Marcus, Angel Porgador, Ronit Rosenfeld, Ohad Mazor
Publikováno v:
Antibodies, Vol 10, Iss 4, p 45 (2021)
The use of passively-administered neutralizing antibodies is a promising approach for the prevention and treatment of SARS-CoV-2 infection. Antibody-mediated protection may involve immune system recruitment through Fc-dependent activation of effector
Externí odkaz:
https://doaj.org/article/f495194fe72e4ceabd5235ae8b934f3c
Autor:
Theodor Chitlaru, Erez Bar-Haim, Liat Bar-On, Shahar Rotem, Hila Cohen, Uri Elia, David Gur, Moshe Aftalion, Ron Alkalay, Efi Makdasi, Yentl Evgy, Reut Falach, Ma’ayan Israeli, Adi Bercovich-Kinori, Hagit Achdout, Yfat Yahalom-Ronen, Ronit Rosenfeld, Ofer Cohen
Publikováno v:
Pathogens, Vol 10, Iss 8, p 940 (2021)
HLA transgenic mice are instrumental for evaluation of human-specific immune responses to viral infection. Mice do not develop COVID-19 upon infection with SARS-CoV-2 due to the strict tropism of the virus to the human ACE2 receptor. The aim of the c
Externí odkaz:
https://doaj.org/article/a1d471afd83e4f9faf44ecd859a5316e
Autor:
Reut Falach, Anita Sapoznikov, Yentl Evgy, Moshe Aftalion, Arik Makovitzki, Avi Agami, Avishai Mimran, Elad Lerer, Alon Ben David, Ran Zichel, Shahaf Katalan, Amir Rosner, Tamar Sabo, Chanoch Kronman, Yoav Gal
Publikováno v:
Toxins, Vol 12, Iss 6, p 354 (2020)
Ricin, a plant-derived toxin originating from the seeds of Ricinus communis (castor bean plant), is one of the most lethal toxins known. To date, there is no approved post-exposure therapy for ricin exposures. This work demonstrates for the first tim
Externí odkaz:
https://doaj.org/article/8983b4478e4848209053341e5c0b4dfd