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Akademický článek

Inclusion of Medium-Chain Triglyceride in Lipid-Based Formulation of Cannabidiol Facilitates Micellar Solubilization In Vitro, but In Vivo Performance Remains Superior with Pure Sesame Oil Vehicle

Autor: Wanshan Feng, Chaolong Qin, Elena Cipolla, Jong Bong Lee, Atheer Zgair, Yenju Chu, Catherine A. Ortori, Michael J. Stocks, Cris S. Constantinescu, David A. Barrett, Peter M. Fischer, Pavel Gershkovich

Publikováno v: Pharmaceutics, Vol 13, Iss 9, p 1349 (2021)

Oral sesame oil-based formulation facilitates the delivery of poorly water-soluble drug cannabidiol (CBD) to the lymphatic system and blood circulation. However, this natural oil-based formulation also leads to considerable variability in absorption

Externí odkaz: https://doaj.org/article/18e491fd416a4ce9bb0c29eeaac7681e

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Vegetable oils composition affects the intestinal lymphatic transport and systemic bioavailability of co-administered lipophilic drug cannabidiol

Autor: Wanshan Feng, Chaolong Qin, Salah Abdelrazig, Ziyu Bai, Mekha Raji, Randa Darwish, YenJu Chu, Liuhang Ji, David A. Gray, Michael J. Stocks, Cris S. Constantinescu, David A. Barrett, Peter M. Fischer, Pavel Gershkovich

Publikováno v: International journal of pharmaceutics. 624

Although natural sesame oil has been shown to facilitate the lymphatic delivery and oral bioavailability of the highly lipophilic drug cannabidiol (CBD), considerable variability remains an unresolved challenge. Vegetable oils differ substantially in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33cdfc19b6ce82ea523f49054d2c5a5e
https://pubmed.ncbi.nlm.nih.gov/35753538

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