Hypoxia-inducible factor HIF-1α modulates drugs resistance in colon cancer cells

Autor: Lilia Del Riesgo, Alejandro Ondo, Yenith Cuellar, Luisa M. Matheus, Martha L. Pinzon-Daza, Fabio Castillo, Ruth Garzón

Publikováno v: Revista de la Facultad de Medicina, Volume: 66, Issue: 4, Pages: 543-550, Published: DEC 2018
Revista de la Facultad de Medicina, Vol 66, Iss 4, Pp 543-550 (2018)
Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario

Introduction: Drug resistance mechanisms may be associated with decreased cell death and its induction may depend on the response to oxidative stress caused by hypoxia. The correlation between hypoxia-inducible factor HIF-1α, the number of reactive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f187ffc97b101d5cd699b6e6682dfa
https://doi.org/10.15446/revfacmed.v66n4.55149

Oxidative Stress Promotes Doxorubicin-Induced Pgp and BCRP Expression in Colon Cancer Cells Under Hypoxic Conditions

Autor: Martha L, Pinzón-Daza, Yenith, Cuellar-Saenz, Francisco, Nualart, Alejandro, Ondo-Mendez, Lilia, Del Riesgo, Fabio, Castillo-Rivera, Ruth, Garzón

Publikováno v: Journal of cellular biochemistry. 118(7)

P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) are ATP binding cassette (ABC) transporters that are overexpressed in different drug-resistant cancer cell lines. In this study, we investigated whether doxorubicin promotes Pgp and/or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::88a79cca862358074c81107f442e1f98
https://pubmed.ncbi.nlm.nih.gov/28106284