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pro vyhledávání: '"Yeng Jeng Shaw"'
Previous evidence showed the ability of the quinazoline-based α1-adrenoreceptor antagonist doxazosin to suppress prostate tumor growth via apoptosis. In this study, we carried out structural optimization of the chemical nucleus of doxazosin and a su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a0839dbd0a5eb200708432eb15922a
https://doi.org/10.1158/0008-5472.c.6496217
https://doi.org/10.1158/0008-5472.c.6496217
Supplementary Figure 1 from Novel Quinazoline-Based Compounds Impair Prostate Tumorigenesis by Targeting Tumor Vascularity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93199cf66adade6d5546ba4a276df2a1
https://doi.org/10.1158/0008-5472.22369997.v1
https://doi.org/10.1158/0008-5472.22369997.v1
Supplementary Figure 3 from Novel Quinazoline-Based Compounds Impair Prostate Tumorigenesis by Targeting Tumor Vascularity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f13b99a87cd0d997a0ad4a509a2099
https://doi.org/10.1158/0008-5472.22369991.v1
https://doi.org/10.1158/0008-5472.22369991.v1
Supplementary Figure 2 from Novel Quinazoline-Based Compounds Impair Prostate Tumorigenesis by Targeting Tumor Vascularity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ee474e37d3db2db0bc86917d9d89736
https://doi.org/10.1158/0008-5472.22369994.v1
https://doi.org/10.1158/0008-5472.22369994.v1
Autor:
Ching-Shih Chen, Samuel K. Kulp, Yeng-Jeng Shaw, Chung-Wai Shiau, Joseph Fowble, Ya-Ting Yang, Ping-Hui Tseng, Jui-Wen Huang, Jiuxiang Zhu
The blockade of Akt activation through the inhibition of 3-phosphoinositide-dependent kinase-1 (PDK-1) represents a major signaling mechanism whereby celecoxib mediates apoptosis. Celecoxib, however, is a weak PDK-1 inhibitor (IC50, 48 μm), requirin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c95b4a4f9e19aaa9a1d41ecf5b4679d
https://doi.org/10.1158/0008-5472.c.6493743.v1
https://doi.org/10.1158/0008-5472.c.6493743.v1
Supplementary Figure Legends 1-3 from Novel Quinazoline-Based Compounds Impair Prostate Tumorigenesis by Targeting Tumor Vascularity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b39ff8f8d662c2904b24dd7bf6071f
https://doi.org/10.1158/0008-5472.22369988
https://doi.org/10.1158/0008-5472.22369988
Autor:
Samuel K. Kulp, Ping Hui Tseng, Yeng Jeng Shaw, Chung Wai Shiau, Ya Ting Yang, Joseph W. Fowble, Ching-Shih Chen, Jiuxiang Zhu, Jui Wen Huang
Publikováno v:
Cancer Research. 79:1716-1716
The editors are publishing this note to alert the readers to a concern about [this article][1] ([1][2]). The editors were made aware of apparent splicing between Western blot lanes 3 and 4 in Fig. 7B. Ohio State University (Columbus, OH) conducted an
Publikováno v:
Journal of the Chinese Chemical Society. 48:1035-1040
Highly protected mannosamine derivatives are synthesized from protected glucose derivatives having a free hydroxy group at C 2 position. Indium-mediated allylation of protected mannosamine derivatives is investigated.
Autor:
Yeng Jeng Shaw, Wen Lung Cheng, Tien-Yau Luh, S.‐M. Yeh, Puthuparampil P. Kanakamma, Jia Cheng Shieu, Gene-Hsiang Lee, Yu Huey Chen, Shaang Jyh Yiin, Yu Wang, Chuo Chen
Publikováno v:
The Journal of Organic Chemistry. 64:532-539
Acetals containing a neighboring heteroatom react with the Grignard reagent in aromatic hydrocarbon solvents regioselectively. The auxiliary moiety can be hydroxy, alkoxy, or amino but not sulfur. Chelation plays a key role in directing the regiosele
Publikováno v:
Journal of medicinal chemistry. 47(18)
The alpha1-adrenoreceptor antagonist doxazosin induces apoptosis in malignant cells with moderate potency via an alpha1-adrenoreceptor-independent mechanism. Here, we demonstrate that the ability of doxazosin to induce apoptosis in PC-3 prostate canc